caliPER: A software for blood-free parametric Patlak mapping using PET/MRI input function

caliPER: A software for blood-free parametric Patlak mapping using PET/MRI input function

•caliPER is an adaptable image processing software for extracting image-derived input functions and generating parametric maps of irreversible PET tracer uptake.•Anatomical (T1- weighted/T2-weighted/time-of-flight angiography) MRI carefully aligned to PET provides a robust approach for delineation o...

Full description

Saved in:
Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Vol. 256; p. 119261
Main Authors: Dassanayake, Praveen, Cui, Lumeng, Finger, Elizabeth, Kewin, Matthew, Hadaway, Jennifer, Soddu, Andrea, Jakoby, Bjoern, Zuehlsdorf, Sven, Lawrence, Keith S St, Moran, Gerald, Anazodo, Udunna C
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-08-2022
Elsevier Limited
Elsevier
Subjects:
Accuracy
Algorithms
Arteries
Automation
Blood
Blood vessels
Dementia
Dementia disorders
Frontotemporal dementia
Glucose
Image-derived input function
Magnetic resonance imaging
Metabolic rate
Neuroimaging
Parametric imaging
Patlak graphical analysis
PET/MRI
Pharmacokinetics
Positron emission tomography
Probes
Prostate cancer
Registration
Sampling
Software
Germany
Patlak graphical analysis
PET/MRI
Image-derived input function
Parametric imaging
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•caliPER is an adaptable image processing software for extracting image-derived input functions and generating parametric maps of irreversible PET tracer uptake.•Anatomical (T1- weighted/T2-weighted/time-of-flight angiography) MRI carefully aligned to PET provides a robust approach for delineation of vessels on PET, eliminating the need for serial blood sampling for input functions.•Application of caliPER in modelling glucose uptake in patients with Frontotemporal dementia, demonstrates the feasibility of absolute quantification of cerebral metabolic rate of glucose in clinical populations. Routine clinical use of absolute PET quantification techniques is limited by the need for serial arterial blood sampling for input function and more importantly by the lack of automated pharmacokinetic analysis tools that can be readily implemented in clinic with minimal effort. PET/MRI provides the ability for absolute quantification of PET probes without the need for serial arterial blood sampling using image-derived input functions (IDIFs). Here we introduce caliPER, a modular and scalable software for simplified pharmacokinetic modeling of PET probes with irreversible uptake or binding based on PET/MR IDIFs and Patlak Plot analysis. caliPER generates regional values or parametric maps of net influx rate (Ki) using reconstructed dynamic PET images and anatomical MRI aligned to PET for IDIF vessel delineation. We evaluated the performance of caliPER for blood-free region-based and pixel-wise Patlak analyses of [18F] FDG by comparing caliPER IDIF to serial arterial blood input functions and its application in imaging brain glucose hypometabolism in Frontotemporal dementia. IDIFs corrected for partial volume errors including spill-out and spill-in effects were similar to arterial blood input functions with a general bias of around 6–8%, even for arteries <5 mm. The Ki and cerebral metabolic rate of glucose estimated using caliPER IDIF were similar to estimates using arterial blood sampling (<2%) and within limits of whole brain values reported in literature. Overall, caliPER is a promising tool for irreversible PET tracer quantification and can simplify the ability to perform parametric analysis in clinical settings without the need for blood sampling.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2022.119261