Search Results - "Zuco, V."

Targeting DNA topoisomerase I with non-camptothecin poisons by Beretta, G L, Zuco, V, Perego, P, Zaffaroni, N

“…DNA topoisomerase I is required for DNA relaxation during a variety of cellular functions. The identification of camptothecins as specific enzyme poisons and…”
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Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour by Stacchiotti, S, Saponara, M, Frapolli, R, Tortoreto, M, Cominetti, D, Provenzano, S, Negri, T, Dagrada, G.P, Gronchi, A, Colombo, C, Vincenzi, B, Badalamenti, G, Zuco, V, Renne, S.L, Collini, P, Morosi, C, Dei Tos, A.P, Bello, E, Pilotti, S, Casali, P.G, D'Incalci, M, Zaffaroni, N

“…Abstract Background Preclinical models that mimic pathological and molecular features of solitary fibrous tumour (SFT) represent an important tool to select…”
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Namitecan: a hydrophilic camptothecin with a promising preclinical profile by Beretta, G L, Zuco, V, De Cesare, M, Perego, P, Zaffaroni, N

“…Camptothecins are still among the most widely prescribed and effective anticancer drugs. Unfortunately, important drawbacks including water insolubility,…”
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Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models by Pisano, C, Vesci, L, Foderà, R, Ferrara, FF, Rossi, C, De Cesare, M, Zuco, V, Pratesi, G, Supino, R, Zunino, F

“…Background: The novel adamantyl retinoid ST1926 is a potent inducer of apoptosis in ovarian carcinoma cells. Since the pro-apoptotic effect is associated with…”
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Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response by Gatti, L, Supino, R, Perego, P, Pavesi, R, Caserini, C, Carenini, N, Righetti, S C, Zuco, V, Zunino, F

“…Mononuclear and multinuclear platinum complexes are known to induce distinct types of DNA lesions and exhibit different profiles of antitumor activity, in…”
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A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line by Supino, R, Perego, P, Gatti, L, Caserini, C, Leonetti, C, Colantuono, M, Zuco, V, Carenini, N, Zupi, G, Zunino, F

“…Based on the role of p53 in the control of apoptosis following DNA damage, the status of the TP53 gene has been implicated as a major determinant of tumour…”
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236 (PB224): Tazemetostat and doxorubicin combined treatment in patient-derived preclinical models of epithelioid sarcoma by Soffientini, C., Arrighetti, N., Zuco, V., Cleris, L., Sigalotti, L., Maestro, R., Percio, S., Barisella, M., Collini, P., Dagrada, G.P., Frezza, A.M., Gronchi, A., Pasquali, S., Stacchiotti, S., Zaffaroni, N.

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Tazemetostat and doxorubicin in patient-derived preclinical models of epithelioid sarcoma (ES) by Pasquali, S., Arrighetti, N., Zuco, V., Tortoreto, M., Soffientini, C., Sigalotti, L., Maestro, R., Percio, S., Barisella, M., Collini, P., Dagrada, G., Frezza, A.M., Gronchi, A., Stacchiotti, S., Zaffaroni, N.

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Induction of apoptosis and stress response in ovarian carcinoma cell lines treated with ST1926, an atypical retinoid by Zuco, V, Zanchi, C, Cassinelli, G, Lanzi, C, Supino, R, Pisano, C, Zanier, R, Giordano, V, Garattini, E, Zunino, F

“…To understand the molecular mechanisms mediating apoptosis induction by a novel atypical retinoid, ST1926, the cellular response to drug treatment was…”
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Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968 by Pisano, Claudio, Zuco, Valentina, De Cesare, Michelandrea, Benedetti, Valentina, Vesci, Loredana, Foderà, Rosanna, Bucci, Federica, Aulicino, Concetta, Penco, Sergio, Carminati, Paolo, Zunino, Franco

“…Abstract ST1968, a novel hydrophilic camptothecin analogue of the 7-oxyiminomethyl series, is characterised by the formation of stable DNA–topoisomerase I…”
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Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells by Lanzi, Cinzia, Cassinelli, Giuliana, Cuccuru, Giuditta, Supino, Rosanna, Zuco, Valentina, Ferlini, Cristiano, Scambia, Giovanni, Zunino, Franco

“…BACKGROUND Defects in the cell cycle machinery of prostate cancer cells might impair the efficiency of cell cycle checkpoints and affect the cell response to…”
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Development of Resistance to the Atypical Retinoid, ST1926, in the Lung Carcinoma Cell Line H460 Is Associated with Reduced Formation of DNA Strand Breaks and a Defective DNA Damage Response by Zuco, Valentina, Zanchi, Chiara, Lanzi, Cinzia, Beretta, Giovanni L., Supino, Rosanna, Pisano, Claudio, Barbarino, Marcella, Zanier, Romina, Bucci, Federica, Aulicino, Concetta, Carminati, Paolo, Zunino, Franco

“…Atypical retinoids are potent inducers of apoptosis, but activation of the apoptotic pathway seems to be independent of retinoid receptors. Previous studies…”
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UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53–replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells by Riva, Federica, Zuco, Valentina, Vink, Ard A., Supino, Rosanna, Prosperi, Ennio

“…The tumour suppressor gene TP53 plays an important role in the regulation of DNA repair, and particularly of nucleotide excision repair. The influence of p53…”
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