House dust mite avoidance for children with asthma in homes of low-income families

Background: Home exposure to high levels of house dust mite allergen has been shown to aggravate airways reactivity and asthma. Objective: The purpose of this study was to determine whether specific house dust mite control measures could reduce exposure levels and asthma severity. Methods: This doub...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 103; no. 6; pp. 1069 - 1074
Main Authors:	Shapiro, Gail G., Wighton, Timothy G., Chinn, Tamara, Zuckrman, Jon, Eliassen, A.Heather, Picciano, Joseph F., Platts-Mills, Thomas A.E.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01-06-1999 Elsevier
Subjects:	Adolescent Air Pollution, Indoor - prevention & control Allergens - analysis Allergic diseases Animals Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - therapeutic use Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Antigens - analysis Asthma Asthma - drug therapy Asthma - physiopathology Beclomethasone - administration & dosage Biological and medical sciences Bronchial Hyperreactivity - immunology bronchial hyperresponsiveness Child Cromolyn Sodium - administration & dosage Cromolyn Sodium - therapeutic use Dust dust mite environmental controls Environmental Pollutants - immunology Glycoproteins - analysis Humans Immunopathology Medical sciences Methacholine Chloride Mites - immunology Respiratory and ent allergic diseases Respiratory Function Tests Socioeconomic Factors Triamcinolone - administration & dosage Triamcinolone - therapeutic use United States North America America environmental controls dust mite PEFR bronchial hyperresponsiveness Asthma Acaridae Allergy Socioeconomic status Hyperreactivity Prevention Health and environment Acari Efficiency Obstructive pulmonary disease Child Public health Human Immunopathology Respiratory disease Personal income Acaridida Bronchus Health education Acariformes Arachnida Low Arthropoda Invertebrata Avoidance
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Background: Home exposure to high levels of house dust mite allergen has been shown to aggravate airways reactivity and asthma. Objective: The purpose of this study was to determine whether specific house dust mite control measures could reduce exposure levels and asthma severity. Methods: This double-blinded, randomized trial compared asthma progression over 1 year in children whose homes received standard environmental control intervention with those whose homes received aggressive intervention for dust mite elimination. The primary end point was doubling in PD 20 methacholine. Results: Symptom scores and quality-of-life scores were similar for the standard and aggressive intervention groups. PD 20 methacholine doubling occurred in 9 members of the aggressive intervention group vs 4 control patients ( P < .05). Dust mite levels decreased in the aggressive intervention homes compared with the standard intervention homes ( P < .05). Conclusion: Aggressive dust mite intervention decreased dust mite levels and improved bronchial hyperresponsiveness. (J Allergy Clin Immunol 1999;103:1069-74.)
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0091-6749 1097-6825
DOI:	10.1016/S0091-6749(99)70181-8