Search Results - "Zucconi, Beth E"

Modulation of neoplastic gene regulatory pathways by the RNA-binding factor AUF1 by Zucconi, Beth E, Wilson, Gerald M

“…The mRNA-binding protein AUF1 regulates the expression of many key players in cancer including proto-oncogenes, regulators of apoptosis and the cell cycle, and…”
Get full text

Combined targeting of the BRD4-NUT-p300 axis in NUT midline carcinoma by dual selective bromodomain inhibitor, NEO2734 by Morrison-Smith, Chevaun D, Knox, Tatiana M, Filic, Ivona, Soroko, Kara M, Eschle, Benjamin K, Wilkens, Margaret K, Gokhale, Prafulla C, Giles, Francis, Griffin, Andrew, Brown, Bill, Shapiro, Geoffrey I, Zucconi, Beth E, Cole, Philip A, Lemieux, Madeleine E, French, Christopher A

“…NUT midline carcinoma (NMC) is a rare, aggressive subtype of squamous carcinoma that is driven by the BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds…”
Get full text

Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I‑CBP112 by Zucconi, Beth E, Luef, Birgit, Xu, Wei, Henry, Ryan A, Nodelman, Ilana M, Bowman, Gregory D, Andrews, Andrew J, Cole, Philip A

“…The histone acetyltransferase (HAT) enzymes p300 and CBP are closely related paralogs that serve as transcriptional coactivators and have been found to be…”
Get full text

A Dimer Interface Mutation in Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Its Binding to AU-rich RNA by White, Michael R., Khan, Mohd M., Deredge, Daniel, Ross, Christina R., Quintyn, Royston, Zucconi, Beth E., Wysocki, Vicki H., Wintrode, Patrick L., Wilson, Gerald M., Garcin, Elsa D.

“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme best known for its role in glycolysis. However, extra-glycolytic functions of GAPDH have been…”
Get full text

Assembly of Functional Ribonucleoprotein Complexes by AU-rich Element RNA-binding Protein 1 (AUF1) Requires Base-dependent and -independent RNA Contacts by Zucconi, Beth E., Wilson, Gerald M.

“…AU-rich element RNA-binding protein 1 (AUF1) regulates the stability and/or translational efficiency of diverse mRNA targets, including many encoding products…”
Get full text

Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe–2S cluster by Shimberg, Geoffrey D., Michalek, Jamie L., Oluyadi, Abdulafeez A., Rodrigues, Andria V., Zucconi, Beth E., Neu, Heather M., Ghosh, Shanchari, Sureschandra, Kanisha, Wilson, Gerald M., Stemmler, Timothy L., Michel, Sarah L. J.

“…Cleavage and polyadenylation specificity factor 30 (CPSF30) is a key protein involved in pre-mRNA processing. CPSF30 contains five Cys₃His domains (annotated…”
Get full text

AUF1 promotes let-7b loading on Argonaute 2 by Yoon, Je-Hyun, Jo, Myung Hyun, White, Elizabeth J F, De, Supriyo, Hafner, Markus, Zucconi, Beth E, Abdelmohsen, Kotb, Martindale, Jennifer L, Yang, Xiaoling, Wood, 3rd, William H, Shin, Yu Mi, Song, Ji-Joon, Tuschl, Thomas, Becker, Kevin G, Wilson, Gerald M, Hohng, Sungchul, Gorospe, Myriam

“…Eukaryotic gene expression is tightly regulated post-transcriptionally by RNA-binding proteins (RBPs) and microRNAs. The RBP AU-rich-binding factor 1 (AUF1)…”
Get full text

Alternatively Expressed Domains of AU-rich Element RNA-binding Protein 1 (AUF1) Regulate RNA-binding Affinity, RNA-induced Protein Oligomerization, and the Local Conformation of Bound RNA Ligands by Zucconi, Beth E., Ballin, Jeff D., Brewer, Brandy Y., Ross, Christina R., Huang, Jun, Toth, Eric A., Wilson, Gerald M.

“…AU-rich element RNA-binding protein 1 (AUF1) binding to AU-rich elements (AREs) in the 3′-untranslated regions of mRNAs encoding many cytokines and other…”
Get full text

Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs by Wu, Xiangyue, Chesoni, Sandra, Rondeau, Gaelle, Tempesta, Christi, Patel, Reshma, Charles, Sandy, Daginawala, Naznin, Zucconi, Beth E, Kishor, Aparna, Xu, Guangwu, Shi, Yufang, Li, Mei-Ling, Irizarry-Barreto, Patricia, Welsh, John, Wilson, Gerald M, Brewer, Gary

“…The RNA-binding protein AUF1 binds AU-rich elements in 3'-untranslated regions to regulate mRNA degradation and/or translation. Many of these mRNAs are…”
Get full text

p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia by Man, Na, Mas, Gloria, Karl, Daniel L, Sun, Jun, Liu, Fan, Yang, Qin, Torres-Martin, Miguel, Itonaga, Hidehiro, Martinez, Concepcion, Chen, Shi, Xu, Ye, Duffort, Stephanie, Hamard, Pierre-Jacques, Chen, Chuan, Zucconi, Beth E, Cimmino, Luisa, Yang, Feng-Chun, Xu, Mingjiang, Cole, Philip A, Figueroa, Maria E, Nimer, Stephen D

“…Myelodysplastic syndromes (MDS) are hematopoietic stem and progenitor cell (HSPC) malignancies characterized by ineffective hematopoiesis and an increased risk…”
Get full text

Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP by Zucconi, Beth E, Makofske, Jessica L, Meyers, David J, Hwang, Yousang, Wu, Mingxuan, Kuroda, Mitzi I, Cole, Philip A

“…p300 and CBP are highly related histone acetyltransferase (HAT) enzymes that regulate gene expression, and their dysregulation has been linked to cancer and…”
Get full text

Allosteric regulation of epigenetic modifying enzymes by Zucconi, Beth E, Cole, Philip A

“…[Display omitted] •Allosteric ligands of histone modifying enzymes pose a new drug targeting strategy.•KDM5A, p300/CBP, Gcn5, and PRMT3 have allosteric ligands…”
Get full text

MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma by Kim, Edward, Zucconi, Beth E, Wu, Muzhou, Nocco, Sarah E, Meyers, David J, McGee, Jean S, Venkatesh, Samantha, Cohen, Daniel L, Gonzalez, Estela C, Ryu, Byungwoo, Cole, Philip A, Alani, Rhoda M

“…Histone modifications, largely regulated by histone acetyltransferases (HAT) and histone deacetylases, have been recognized as major regulatory mechanisms…”
Get full text

Alone on the frontline: The first report of PTSD prevalence and risk in de-occupied Ukrainian villages by Ressler, Austin, Hinchey, Liza M, Mast, Jonathan, Zucconi, Beth E, Bratchuk, Anatoliy, Parfenukt, Nadia, Roth, Dianne, Javanbakht, Arash

“…Importance: The ongoing Russian invasion of Ukraine marks a critical juncture in a series of events posing severe threat to the health of Ukrainian citizens…”
Get full text

Reliability of Different RBC Indices and Formulas in Discriminating between β-Thalassemia Minor and other Microcytic Hypochromic Cases by Bordbar, Elahe, Taghipour, Mehdi, Zucconi, Beth E

“…Different indices and formulas of CBC parameters have been suggested as indicators of early stage screenings to detect couples with β-thalassemia minor (BTMi)…”
Get full text

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome by Weinert, Brian T., Narita, Takeo, Satpathy, Shankha, Srinivasan, Balaji, Hansen, Bogi K., Schölz, Christian, Hamilton, William B., Zucconi, Beth E., Wang, Wesley W., Liu, Wenshe R., Brickman, Joshua M., Kesicki, Edward A., Lai, Albert, Bromberg, Kenneth D., Cole, Philip A., Choudhary, Chunaram

“…The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators. Here, we combined quantitative proteomics with CBP/p300-specific…”
Get full text

Reference compounds for characterizing cellular injury in high-content cellular morphology assays by Dahlin, Jayme L., Hua, Bruce K., Zucconi, Beth E., Nelson, Shawn D., Singh, Shantanu, Carpenter, Anne E., Shrimp, Jonathan H., Lima-Fernandes, Evelyne, Wawer, Mathias J., Chung, Lawrence P. W., Agrawal, Ayushi, O’Reilly, Mary, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena, Li, Fengling, Lak, Parnian, Cuellar, Matthew, Cole, Philip A., Meier, Jordan L., Thomas, Tim, Baell, Jonathan B., Brown, Peter J., Walters, Michael A., Clemons, Paul A., Schreiber, Stuart L., Wagner, Bridget K.

“…Robust, generalizable approaches to identify compounds efficiently with undesirable mechanisms of action in complex cellular assays remain elusive. Such a…”
Get full text

Direct Binding of Specific AUF1 Isoforms to Tandem Zinc Finger Domains of Tristetraprolin (TTP) Family Proteins by Kedar, Vishram P., Zucconi, Beth E., Wilson, Gerald M., Blackshear, Perry J.

“…Tristetraprolin (TTP) is the prototype of a family of CCCH tandem zinc finger proteins that can bind to AU-rich elements in mRNAs and promote their decay. TTP…”
Get full text

Post‐transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans by Wells, Melissa L., Washington, Onica L., Hicks, Stephanie N., Nobile, Clarissa J., Hartooni, Nairi, Wilson, Gerald M., Zucconi, Beth E., Huang, Weichun, Li, Leping, Fargo, David C., Blackshear, Perry J.

“…Summary Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins bind to AU‐rich regions in target mRNAs, leading to their deadenylation…”
Get full text

A dimer interface mutation in glyceraldehyde 3-phosphate dehydrogenase regulates its binding to AU-rich RNA by White, Michael R., Khan, Mohd M., Deredge, Daniel, Ross, Christina R., Quintyn, Royston, Zucconi, Beth E., Wysocki, Vicki H., Wintrode, Patrick L., Wilson, Gerald M., Garcin, Elsa D.

Get full text