Maternal high fructose diet exacerbates white adipose tissue thermogenic process in offspring upon exposure to cold temperature

An adverse endogenous environment during early life predisposes to metabolic disorder development. We previously reported adverse metabolic and adipose tissue effects in adult male rats born to dams fed with a fructose-rich diet (FRD). The aim of this work was to determine the effect of a FRD consum...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 287; p. 120066
Main Authors:	Alzamendi, A., Miguel, I., Zubiría, M.G., Gambaro, S.E., Spinedi, E., Giovambattista, A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 15-12-2021 Elsevier BV
Subjects:	Adipogenesis - drug effects Adipogenesis - physiology Adipose tissue Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism Animals Beige adipocytes Body fat Browning Cell differentiation Cold stimuli Cold Temperature - adverse effects Diet Dietary Sugars - administration & dosage Dietary Sugars - toxicity Differentiation Energy Metabolism - drug effects Energy Metabolism - physiology Exposure Female Fructose Fructose - administration & dosage Fructose - toxicity Gene expression Male Males Malnutrition Maternal fructose diet Metabolic disorders Metabolic programming Metabolism Offspring Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - metabolism Rats Rats, Sprague-Dawley Thermogenesis - drug effects Thermogenesis - physiology UCP-1 White adipose tissue Metabolic programming Maternal fructose diet Beige adipocytes White adipose tissue UCP-1
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Summary:	An adverse endogenous environment during early life predisposes to metabolic disorder development. We previously reported adverse metabolic and adipose tissue effects in adult male rats born to dams fed with a fructose-rich diet (FRD). The aim of this work was to determine the effect of a FRD consumed by the pregnant mother on the white adipose tissue (WAT) browning capacity of male offspring at adulthood. Adult SD male offspring from control (C) and FRD-fed mothers were exposed during one week to a cold stimulus. WAT browning capacity was studied through in vivo and in vitro approaches. After cold exposure, WAT browning was higher in fructose-programmed animals as evidenced by an increase in ucp-1 gene expression, protein levels, and higher UCP-1 positive foci. Moreover, pgc1-α gene expression was increased. In vitro studies showed a lower adipogenic capacity in cells of prenatally fructose-exposed animals differentiated with a white differentiation cocktail, while a higher ucp-1 expression was noted when their cells were treated with a pro-beige differentiation cocktail. For the first time we demonstrate that pre-natal fructose exposure predisposes programmed male rats to a higher WAT browning-induced response, under stimulated conditions, despite an apparent lower basal thermogenic capacity. These results should be considered in future studies to generate new therapeutic approaches to deal with adverse programming malnutrition effects. [Display omitted] •Maternal high carbohydrate consumption influences white browning response in offspring.•Under adequate stimulus, adipose precursor cells respond with a higher thermogenic activity.•White adipose tissue browning response depends on maternal diet in utero.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2021.120066