Search Results - "Zubiaur, Pablo"

Association Studies in Clinical Pharmacogenetics by Zubiaur, Pablo, Abad-Santos, Francisco

“…In recent times, the progress of Clinical Pharmacogenetics has been remarkable [...]…”
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“Pharmacogenetics of siponimod: A systematic review” by Díaz-Villamarín et al. – Information is power by Zubiaur, Pablo, Saiz-Rodríguez, Miriam, Abad-Santos, Francisco

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Utility of Therapeutic Drug Monitoring of Imatinib, Nilotinib, and Dasatinib in Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis by García-Ferrer, Manuel, Wojnicz, Aneta, Mejía, Gina, Koller, Dora, Zubiaur, Pablo, Abad-Santos, Francisco

“…This study examined the utility of therapeutic drug monitoring (TDM) of imatinib, nilotinib, and dasatinib in adult patients with chronic-phase chronic myeloid…”
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Genetic Polymorphisms Associated With the Pharmacokinetics, Pharmacodynamics and Adverse Effects of Olanzapine, Aripiprazole and Risperidone by Soria-Chacartegui, Paula, Villapalos-García, Gonzalo, Zubiaur, Pablo, Abad-Santos, Francisco, Koller, Dora

“…Olanzapine, aripiprazole and risperidone are atypical antipsychotics or neuroleptics widely used for schizophrenia treatment. They induce various adverse drug…”
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Polymorphisms in CYP1A2, CYP2C9 and ABCB1 affect agomelatine pharmacokinetics by Saiz-Rodríguez, Miriam, Ochoa, Dolores, Belmonte, Carmen, Román, Manuel, Vieira de Lara, Danilo, Zubiaur, Pablo, Koller, Dora, Mejía, Gina, Abad-Santos, Francisco

“…Background: Agomelatine is an agonist of the melatoninergic receptors used for the treatment of depression. Our aim was to evaluate the effect of genetic…”
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The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice by Grajales, Diana, Vázquez, Patricia, Ruíz-Rosario, Mónica, Tudurí, Eva, Mirasierra, Mercedes, Ferreira, Vítor, Hitos, Ana B., Koller, Dora, Zubiaur, Pablo, Cigudosa, Juan C., Abad-Santos, Francisco, Vallejo, Mario, Quesada, Iván, Tirosh, Boaz, Leibowitz, Gil, Valverde, Ángela M.

“…Aims/hypothesis Second-generation antipsychotic (SGA) drugs have been associated with the development of type 2 diabetes and the metabolic syndrome in patients…”
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Association between CYP2C19 and CYP2B6 phenotypes and the pharmacokinetics and safety of diazepam by Zubiaur, Pablo, Figueiredo-Tor, Laura, Villapalos-García, Gonzalo, Soria-Chacartegui, Paula, Navares-Gómez, Marcos, Novalbos, Jesús, Matas, Miriam, Calleja, Sofía, Mejía-Abril, Gina, Román, Manuel, Ochoa, Dolores, Abad-Santos, Francisco

“…Diazepam is a benzodiazepine (BZD) used worldwide for a variety of conditions. Long-term use of diazepam increases the risk for developing tolerance and…”
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Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates by Saiz-Rodríguez, Miriam, Almenara, Susana, Navares-Gómez, Marcos, Ochoa, Dolores, Román, Manuel, Zubiaur, Pablo, Koller, Dora, Santos, María, Mejía, Gina, Borobia, Alberto M, Rodríguez-Antona, Cristina, Abad-Santos, Francisco

“…Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We aimed to evaluate the influence of these alleles on the…”
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Impact of STAT6 Variants on the Response to Proton Pump Inhibitors and Comorbidities in Patients with Eosinophilic Esophagitis by Soria-Chacartegui, Paula, Navares-Gómez, Marcos, Molina-Jiménez, Francisca, Laserna-Mendieta, Emilio J, Arias-González, Laura, Majano, Pedro, Casabona, Sergio, Lucendo, Alfredo J, Abad-Santos, Francisco, Santander, Cecilio, Zubiaur, Pablo

“…Proton pump inhibitors (PPIs) are the first-line drug for eosinophilic esophagitis (EoE), although it is estimated that there is a lack of histological…”
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Influence of CYP2B6 activity score on the pharmacokinetics and safety of single dose efavirenz in healthy volunteers by Zubiaur, Pablo, Saiz-Rodríguez, Miriam, Ochoa, Dolores, Belmonte, Carmen, Román, Manuel, Mejía, Gina, Martín-Vilchez, Samuel, Abad-Santos, Francisco

“…Efavirenz is a non-nucleoside reverse transcriptase inhibitor used as first-line therapy for the treatment of HIV infection. Cytochrome P450 (CYP) CYP2B6 G516T…”
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Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects by Koller, Dora, Belmonte, Carmen, Lubomirov, Rubin, Saiz-Rodríguez, Miriam, Zubiaur, Pablo, Román, Manuel, Ochoa, Dolores, Carcas, Antonio, Wojnicz, Aneta, Abad-Santos, Francisco

“…Background: Pupillometry is used for the detection of autonomic dysfunction related to numerous diseases and drug administration. Genetic variants in…”
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Corrosion Behaviour of Mg98.5Nd1Zn0.5 (at. %) Alloy in Phosphate Buffered Saline Solution by Cabeza, Sandra, Pérez Zubiaur, Pablo, Garcés, Gerardo, Andrade, Carmen, Adeva, Paloma

“…The corrosion behaviour of Mg98.5-Nd1-Zn0.5 (at. %) alloy was studied in phosphate buffered saline (PBS) solution to evaluate its degradation performance as a…”
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Impact of polymorphisms in transporter and metabolizing enzyme genes on olanzapine pharmacokinetics and safety in healthy volunteers by Zubiaur, Pablo, Soria-Chacartegui, Paula, Koller, Dora, Navares-Gómez, Marcos, Ochoa, Dolores, Almenara, Susana, Saiz-Rodríguez, Miriam, Mejía-Abril, Gina, Villapalos-García, Gonzalo, Román, Manuel, Martín-Vílchez, Samuel, Abad-Santos, Francisco

“…[Display omitted] •CYP2C9 phenotype and SLC22A1 and APOC3 polymorphism were related to variability in olanzapine pharmacokinetics.•CYP1A2 and CYP2D6…”
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Impact of Sex and Genetic Variation in Relevant Pharmacogenes on the Pharmacokinetics and Safety of Valsartan, Olmesartan and Hydrochlorothiazide by Soria-Chacartegui, Paula, Zubiaur, Pablo, Ochoa, Dolores, Navares-Gómez, Marcos, Abbes, Houwaida, Villapalos-García, Gonzalo, de Miguel, Alejandro, González-Iglesias, Eva, Rodríguez-Lopez, Andrea, Mejía-Abril, Gina, Martín-Vilchez, Samuel, Luquero-Bueno, Sergio, Román, Manuel, Abad-Santos, Francisco

“…Drug combination therapy is the most common pharmacological strategy for hypertension management. No pharmacogenetic biomarkers for guiding hypertension…”
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NAT2 phenotype alters pharmacokinetics of rivaroxaban in healthy volunteers by Villapalos-García, Gonzalo, Zubiaur, Pablo, Ochoa, Dolores, Soria-Chacartegui, Paula, Navares-Gómez, Marcos, Matas, Miriam, Mejía-Abril, Gina, Casajús-Rey, Ana, Campodónico, Diana, Román, Manuel, Martín-Vílchez, Samuel, Candau-Ramos, Carmen, Aldama-Martín, Marina, Abad-Santos, Francisco

“…Rivaroxaban is a direct inhibitor of factor Xa, a member of direct oral anticoagulant group of drugs (DOACs). Despite being a widely extended alternative to…”
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ABCB1 C3435T, G2677T/A and C1236T variants have no effect in eslicarbazepine pharmacokinetics by Zubiaur, Pablo, del Peso-Casado, Miriam, Ochoa, Dolores, Enrique-Benedito, Teresa, Mejía-Abril, Gina, Navares, Marcos, Villapalos-García, Gonzalo, Román, Manuel, Abad-Santos, Francisco, Ovejero-Benito, María Carmen

“…Eslicarbazepine acetate is a third-generation anti-epileptic prodrug quickly and extensively transformed to eslicarbazepine after oral administration…”
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Genetic variation in UGT1A1 is not associated with altered liver biochemical parameters in healthy volunteers participating in bioequivalence trials by González-Iglesias, Eva, Ochoa, Dolores, Román, Manuel, Soria-Chacartegui, Paula, Martín-Vilchez, Samuel, Navares-Gómez, Marcos, De Miguel, Alejandro, Zubiaur, Pablo, Rodríguez-Lopez, Andrea, Abad-Santos, Francisco, Novalbos, Jesús

“…Bioequivalence clinical trials are conducted in healthy volunteers whose blood tests should be within normal limits; individuals with Gilbert syndrome (GS) are…”
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Use of Exposure Data to Establish Causality in Drug-Adverse Event Relationships: An Example with Desvenlafaxine by Rodríguez-Lopez, Andrea, Mejía-Abril, Gina, Zubiaur, Pablo, Calleja, Sofía, Román, Manuel, Abad-Santos, Francisco, Ochoa, Dolores

“…Causality algorithms help establish relationships between drug use and adverse event (AE) occurrence. High drug exposure leads to a higher likelihood of an AE…”
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Evaluation of the role of metabolizing enzymes and transporter variants in ezetimibe pharmacokinetics by González-Iglesias, Eva, Ochoa, Dolores, Navares-Gómez, Marcos, Zubiaur, Pablo, Aldama, Marina, de la Torre, Tamara, Ríos-Rodríguez, Marta de Los, Soria-Chacartegui, Paula, Rodríguez-Lopez, Andrea, Abad-Santos, Francisco, Novalbos, Jesús

“…Ezetimibe inhibits cholesterol uptake by modulation of intestinal sterol absorption. Currently, although some studies have shown alterations in ezetimibe…”
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Impact of polymorphisms in CYP and UGT enzymes and ABC and SLCO1B1 transporters on the pharmacokinetics and safety of desvenlafaxine by Calleja, Sofía, Zubiaur, Pablo, Ochoa, Dolores, Villapalos-García, Gonzalo, Mejia-Abril, Gina, Soria-Chacartegui, Paula, Navares-Gómez, Marcos, de Miguel, Alejandro, Román, Manuel, Martín-Vílchez, Samuel, Abad-Santos, Francisco

“…Venlafaxine pharmacokinetic variability and pharmacotherapy outcomes are well known to be related to CYP2D6 pharmacogenetic phenotype. In contrast, scarce…”
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