Search Results - "Zuberbier, Torsten"

Cytokines Stimulated by IL-33 in Human Skin Mast Cells: Involvement of NF-κB and p38 at Distinct Levels and Potent Co-Operation with FcεRI and MRGPRX2 by Franke, Kristin, Wang, Zhao, Zuberbier, Torsten, Babina, Magda

“…The IL-1 family cytokine IL-33 activates and re-shapes mast cells (MCs), but whether and by what mechanisms it elicits cytokines in MCs from human skin remains…”
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Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision by Brożek, Jan L., MD, PhD, Bousquet, Jean, MD, PhD, Baena-Cagnani, Carlos E., MD, Bonini, Sergio, MD, Canonica, G. Walter, MD, Casale, Thomas B., MD, van Wijk, Roy Gerth, MD, PhD, Ohta, Ken, MD, PhD, Zuberbier, Torsten, MD, Schünemann, Holger J., MD, PhD, MSc

“…Background Allergic rhinitis represents a global health problem affecting 10% to 20% of the population. The Allergic Rhinitis and its Impact on Asthma (ARIA)…”
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Nickel Challenge In Vitro Affects CD38 and HLA-DR Expression in T Cell Subpopulations from the Blood of Patients with Nickel Allergy by Artuc, Metin, Zuberbier, Torsten, Peiser, Matthias

“…Nickel allergy is a major health problem and shows clinical manifestation of contact eczema. The response of specific lymphocyte subpopulations in sensitized…”
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Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation by Babina, Magda, Wang, Zhao, Franke, Kristin, Guhl, Sven, Artuc, Metin, Zuberbier, Torsten

“…Mast cells (MCs) are the principal effector cells of IgE-mediated allergy. IL-33 is released by resident skin cells as alarmin upon tissue damage or allergen…”
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Physical Urticarias and Cholinergic Urticaria by Abajian, Marina, Schoepke, Nicole, MD, Altrichter, Sabine, MD, Zuberbier, Torsten, MD, Maurer, Marcus, MD

“…Physical urticarias are a unique subgroup of chronic urticaria in which urticarial responses can be reproducibly induced by different specific physical stimuli…”
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Redefinition of the human mast cell transcriptome by deep-CAGE sequencing by Motakis, Efthymios, Guhl, Sven, Ishizu, Yuri, Itoh, Masayoshi, Kawaji, Hideya, de Hoon, Michiel, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Zuberbier, Torsten, Forrest, Alistair R.R., Babina, Magda

“…Mast cells (MCs) mature exclusively in peripheral tissues, hampering research into their developmental and functional programs. Here, we employed deep cap…”
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MRGPRX2 is negatively targeted by SCF and IL‐4 to diminish pseudo‐allergic stimulation of skin mast cells in culture by Babina, Magda, Wang, Zhao, Artuc, Metin, Guhl, Sven, Zuberbier, Torsten

“…MRGPRX2 was recently uncovered as the “missing link” in clinically relevant mast cell (MC) activation explaining previously puzzling phenomena. It is the…”
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IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper by Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R. Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen-Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal M., DuBuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosário Filho, Nelson A., Rosenwasser, Lanny, Sánchez Borges, Mario A., Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., Zuberbier, Torsten

“…Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides…”
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Retinoic Acid Negatively Impacts Proliferation and MCTC Specific Attributes of Human Skin Derived Mast Cells, but Reinforces Allergic Stimulability by Babina, Magda, Artuc, Metin, Guhl, Sven, Zuberbier, Torsten

“…The Vitamin-A-metabolite retinoic acid (RA) acts as a master regulator of cellular programs. Mast cells (MCs) are primary effector cells of type-I-allergic…”
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CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells by Franke, Kristin, Bal, Gürkan, Li, Zhuoran, Zuberbier, Torsten, Babina, Magda

“…cAMP response element binding protein (CREB) functions as a prototypical stimulus-inducible transcription factor (TF) that initiates multiple cellular changes…”
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Short-term Heat Application Reduces Itch Intensity in Atopic Dermatitis: Insights from Mechanical Induction and Real-life Episodes by Fluhr, Joachim W, Herzog, Leonie, Darlenski, Razvigor, Mentel, Tim, Zuberbier, Torsten

“…Heat application is known to activate transient receptor potential (TRP) channels, which play a crucial role in sensory perception, including itch. In this…”
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Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK by Babina, Magda, Wang, Zhao, Franke, Kristin, Zuberbier, Torsten

“…Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as "alarmin" and driver of Th2-immunity. Aberrant…”
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Inhaled corticosteroids in early COVID‐19—A tale of many facets by Klimek, Ludger, Akdis, Cezmi A., Jutel, Marek, Zuberbier, Torsten, Bousquet, Jean

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Trends in smoking initiation in Europe over 40 years: A retrospective cohort study by Marcon, Alessandro, Pesce, Giancarlo, Calciano, Lucia, Bellisario, Valeria, Dharmage, Shyamali C, Garcia-Aymerich, Judith, Gislasson, Thorarinn, Heinrich, Joachim, Holm, Mathias, Janson, Christer, Jarvis, Deborah, Leynaert, Bénédicte, Matheson, Melanie C, Pirina, Pietro, Svanes, Cecilie, Villani, Simona, Zuberbier, Torsten, Minelli, Cosetta, Accordini, Simone

“…Tobacco consumption is the largest avoidable health risk. Understanding changes of smoking over time and across populations is crucial to implementing health…”
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The role of IL-17, IL-23 and IL-31, IL-33 in allergic skin diseases by Topal, Fatih A., Zuberbier, Torsten, Makris, Michael P., Hofmann, Maja

“…Allergic skin diseases such as urticaria, atopic dermatitis and allergic contact dermatitis are among the most common skin diseases with severe socioeconomic…”
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Responsiveness and Minimal Important Difference of the Urticaria Control Test (UCT) by Ohanyan, Tatevik, MD, Schoepke, Nicole, MD, Bolukbasi, Bediha, MD, Metz, Martin, MD, Hawro, Tomasz, MD, Zuberbier, Torsten, MD, Peveling-Oberhag, Adriane, MD, Staubach, Petra, MD, Maurer, Marcus, MD, Weller, Karsten, MD

“…Short Summary This study demonstrates the responsiveness of the Urticaria Control Test (UCT). Changes of its score by 3 points or more reflect a clinically…”
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1,25‐dihydroxyvitamin D3 promotes IL‐10 production in human B cells by Heine, Guido, Niesner, Uwe, Chang, Hyun‐Dong, Steinmeyer, Andreas, Zügel, Ulrich, Zuberbier, Torsten, Radbruch, Andreas, Worm, Margitta

“…1,25‐dihydroxyvitamin D3 (calcitriol) regulates immune responses, e.g., inhibits expression of IgE by B cells and enhances expression of IL‐10 by dendritic…”
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High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: A randomized, placebo-controlled, crossover study by Siebenhaar, Frank, MD, Degener, Franziska, Zuberbier, Torsten, MD, Martus, Peter, PhD, Maurer, Marcus, MD

“…Background Increased dosing of nonsedating antihistamines is recommended by the current European Academy of Allergology and Clinical Immunology/Global Allergy…”
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Bronchodilator reversibility in asthma and COPD: findings from three large population studies by Janson, Christer, Malinovschi, Andrei, Amaral, Andre F S, Accordini, Simone, Bousquet, Jean, Buist, A Sonia, Canonica, Giorgio Walter, Dahlén, Barbro, Garcia-Aymerich, Judith, Gnatiuc, Louisa, Kowalski, Marek L, Patel, Jaymini, Tan, Wan, Torén, Kjell, Zuberbier, Torsten, Burney, Peter, Jarvis, Deborah

“…Bronchodilator response (BDR) testing is used as a diagnostic method in obstructive airway diseases. The aim of this investigation was to compare different…”
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Urticaria : Current opinions about etiology, diagnosis and therapy by ZUBERBIER, Torsten, MAURER, Marcus

“…In the last few decades an increasing understanding of the pathomechanisms involved in urticaria has highlighted the heterogeneity of different subtypes…”
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