Search Results - "Zubarev, Roman A"

The challenge of the proteome dynamic range and its implications for in-depth proteomics by Zubarev, Roman A.

“…The dynamic range of the cellular proteome approaches seven orders of magnitude—from one copy per cell to ten million copies per cell. Since a proteome's…”
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Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid by Spengler, Julia, Lugonja, Božo, Jimmy Ytterberg, A., Zubarev, Roman A., Creese, Andrew J., Pearson, Mark J., Grant, Melissa M., Milward, Michael, Lundberg, Karin, Buckley, Christopher D., Filer, Andrew, Raza, Karim, Cooper, Paul R., Chapple, Iain L., Scheel‐Toellner, Dagmar

“…Objective In the majority of patients with rheumatoid arthritis (RA), antibodies specifically recognize citrullinated autoantigens that are generated by…”
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Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides by Yang, Hongqian, Zubarev, Roman A

“…One of the most frequent modifications in proteins and peptides is the deamidation of asparagine, a spontaneous non-enzymatic reaction leading to a mixture of…”
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Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171 by Subramaniam, Agatheeswaran, Žemaitis, Kristijonas, Talkhoncheh, Mehrnaz Safaee, Yudovich, David, Bäckström, Alexandra, Debnath, Shubhranshu, Chen, Jun, Jain, Mayur Vilas, Galeev, Roman, Gaetani, Massimiliano, Zubarev, Roman A., Larsson, Jonas

“…Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of…”
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Electron-capture dissociation tandem mass spectrometry by Zubarev, Roman A

“…Electron capture dissociation (ECD) is a new fragmentation technique used in Fourier transform ion cyclotron resonance mass spectrometry and is complementary…”
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ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery by Saei, Amir Ata, Beusch, Christian Michel, Chernobrovkin, Alexey, Sabatier, Pierre, Zhang, Bo, Tokat, Ülkü Güler, Stergiou, Eleni, Gaetani, Massimiliano, Végvári, Ákos, Zubarev, Roman A.

“…Deconvolution of targets and action mechanisms of anticancer compounds is fundamental in drug development. Here, we report on ProTargetMiner as a publicly…”
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Optimizing Recombinant Protein Production in the Escherichia coli Periplasm Alleviates Stress by Baumgarten, Thomas, Ytterberg, A Jimmy, Zubarev, Roman A, de Gier, Jan-Willem

“…In , many recombinant proteins are produced in the periplasm. To direct these proteins to this compartment, they are equipped with an N-terminal signal…”
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EThcD Benefits for the Sequencing Inside Intramolecular Disulfide Cycles of Amphibian Intact Peptides by Vasileva, Irina D., Samgina, Tatiana Yu, Meng, Zhaowei, Zubarev, Roman A., Lebedev, Albert T.

“…Disulfide bonds formed by a pair of cysteine residues in the peptides’ backbone represent a certain problem for their sequencing by means of mass spectrometry…”
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GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics by Wright, Shane C., Motso, Aikaterini, Koutsilieri, Stefania, Beusch, Christian M., Sabatier, Pierre, Berghella, Alessandro, Blondel-Tepaz, Élodie, Mangenot, Kimberley, Pittarokoilis, Ioannis, Sismanoglou, Despoina-Christina, Le Gouill, Christian, Olsen, Jesper V., Zubarev, Roman A., Lambert, Nevin A., Hauser, Alexander S., Bouvier, Michel, Lauschke, Volker M.

“…G protein-coupled receptors are important drug targets that engage and activate signaling transducers in multiple cellular compartments. Delineating…”
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System-wide identification and prioritization of enzyme substrates by thermal analysis by Saei, Amir Ata, Beusch, Christian M., Sabatier, Pierre, Wells, Juan Astorga, Gharibi, Hassan, Meng, Zhaowei, Chernobrovkin, Alexey, Rodin, Sergey, Näreoja, Katja, Thorsell, Ann-Gerd, Karlberg, Tobias, Cheng, Qing, Lundström, Susanna L., Gaetani, Massimiliano, Végvári, Ákos, Arnér, Elias S. J., Schüler, Herwig, Zubarev, Roman A.

“…Despite the immense importance of enzyme–substrate reactions, there is a lack of general and unbiased tools for identifying and prioritizing substrate proteins…”
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Massive Solubility Changes in Neuronal Proteins upon Simulated Traumatic Brain Injury Reveal the Role of Shockwaves in Irreversible Damage by Saei, Amir Ata, Gharibi, Hassan, Lyu, Hezheng, Nilsson, Brady, Jafari, Maryam, Von Holst, Hans, Zubarev, Roman A

“…We investigated the immediate molecular consequences of traumatic brain injuries (TBIs) using a novel proteomics approach. We simulated TBIs using an…”
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Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin by Saei, Amir Ata, Gullberg, Hjalmar, Sabatier, Pierre, Beusch, Christian M., Johansson, Katarina, Lundgren, Bo, Arvidsson, Per I., Arnér, Elias S.J., Zubarev, Roman A.

“…Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome…”
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Urinary prognostic biomarkers and classification of IgA nephropathy by high resolution mass spectrometry coupled with liquid chromatography by Kalantari, Shiva, Rutishauser, Dorothea, Samavat, Shiva, Nafar, Mohsen, Mahmudieh, Leyla, Rezaei-Tavirani, Mostafa, Zubarev, Roman A

“…IgA nephropathy is the most common cause of primary glomerulonephritis. There are different pathologic biopsy-based scoring systems in use, but there is no…”
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Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases by Fernandez Lahore, Gonzalo, Förster, Michael, Johannesson, Martina, Sabatier, Pierre, Lönnblom, Erik, Aoun, Mike, He, Yibo, Nandakumar, Kutty Selva, Zubarev, Roman A., Holmdahl, Rikard

“…Complex autoimmune diseases are sexually dimorphic. An interplay between predisposing genetics and sex-related factors probably controls the sex discrepancy in…”
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DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes by Sen, Ilke, Zhou, Xin, Chernobrovkin, Alexey, Puerta-Cavanzo, Nataly, Kanno, Takaharu, Salignon, Jérôme, Stoehr, Andrea, Lin, Xin-Xuan, Baskaner, Bora, Brandenburg, Simone, Björkegren, Camilla, Zubarev, Roman A., Riedel, Christian G.

“…In C. elegans, the conserved transcription factor DAF-16/FOXO is a powerful aging regulator, relaying dire conditions into expression of stress resistance and…”
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On the Effect of Planetary Stable Isotope Compositions on Growth and Survival of Terrestrial Organisms by Xie, Xueshu, Zubarev, Roman A

“…Isotopic compositions of reactants affect the rates of chemical and biochemical reactions. Usually it is assumed that heavy stable isotope enrichment leads to…”
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The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage by Zhang, Xiaonan, Pellegrini, Paola, Saei, Amir Ata, Hillert, Ellin-Kristina, Mazurkiewicz, Magdalena, Olofsson, Maria Hägg, Zubarev, Roman A., D'Arcy, Pádraig, Linder, Stig

“…[Display omitted] Human cancers are characterized by intrinsic or acquired resistance to apoptosis and evasion of apoptosis has been proposed to contribute to…”
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S100A6 is a critical regulator of hematopoietic stem cells by Grahn, Tan Hooi Min, Niroula, Abhishek, Végvári, Ákos, Oburoglu, Leal, Pertesi, Maroulio, Warsi, Sarah, Safi, Fatemeh, Miharada, Natsumi, Garcia, Sandra C., Siva, Kavitha, Liu, Yang, Rörby, Emma, Nilsson, Björn, Zubarev, Roman A., Karlsson, Stefan

“…The fate options of hematopoietic stem cells (HSCs) include self-renewal, differentiation, migration, and apoptosis. HSCs self-renewal divisions in stem cells…”
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First Immunoassay for Measuring Isoaspartate in Human Serum Albumin by Wang, Jijing, Lundström, Susanna L, Seelow, Sven, Rodin, Sergey, Meng, Zhaowei, Astorga-Wells, Juan, Jia, Qinyu, Zubarev, Roman A

“…Isoaspartate (isoAsp) is a damaging amino acid residue formed in proteins mostly as a result of spontaneous deamidation of asparaginyl residues. An association…”
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First Experimental Evidence for Reversibility of Ammonia Loss from Asparagine by Wang, Jijing, Rodin, Sergey, Saei, Amir Ata, Zhang, Xuepei, Zubarev, Roman A.

“…Ammonia loss from L-asparaginyls is a nonenzymatic reaction spontaneously occurring in all proteins and eventually resulting in damaging isoaspartate residues…”
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