Search Results - "Zu, Shijia"

BPTF inhibition antagonizes colorectal cancer progression by transcriptionally inactivating Cdc25A by Guo, Ping, Zu, Shijia, Han, Shilong, Yu, Wendan, Xue, Guoqing, Lu, Xiaona, Lin, Hua, Zhao, Xinrui, Lu, Haibo, Hua, Chunyu, Wan, Xinyu, Ru, Liyuan, Guo, Ziyue, Ge, Hanxiao, Lv, Kuan, Zhang, Guohui, Deng, Wuguo, Luo, Cheng, Guo, Wei

“…As the largest subunit of the nuclear remodeling factor complex, Bromodomain PHD Finger Transcription Factor (BPTF) has been reported to be involved in…”
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A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region by Jiang, Hao, Zu, Shijia, Lu, Yu, Sun, Zhongya, Adeerjiang, Akejiang, Guo, Qiao, Zhang, Huimin, Dong, Chen, Wu, Qiqi, Ding, Hong, Du, Daohai, Wang, Mingliang, Liu, Chuanpeng, Tang, Yong, Liang, Zhongjie, Luo, Cheng

“…[Display omitted] •A crystal structure of RhoA-GDP with switch II region flipped outward.•Conformational changes of switch II regulate GAP dissociation and GEF…”
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Discovery of CECR2 Bromodomain Inhibitors with High Selectivities over BPTF Bromodomain by Lu, Haibo, Zu, Shijia, Duan, Zhe, Feng, Yueyao, Wang, Jie, Ma, Jingyi, Li, Qi, Chen, Dongying, Li, Bo, Chen, Kaixian, Luo, Cheng, Lin, Jin, Lu, Tian, Lin, Hua

“…Comprehensive Summary Cat's eye syndrome chromosome candidate 2 bromodomain (CECR2 BRD) and Bromodomain PHD transcription factor bromodomain (BPTF BRD) are the…”
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Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold by Lu, Haibo, Lu, Tian, Zu, Shijia, Duan, Zhe, Guang, Yiman, Li, Qi, Ma, Jingyi, Chen, Dongying, Li, Bo, Lu, Wenchao, Jiang, Hualiang, Luo, Cheng, Ye, Deyong, Chen, Kaixian, Lin, Hua

“…[Display omitted] •The binding models of TP-248 with CECR2 BRD and BPTF BRD were analyzed.•Intensive SAR study lead to a highly potent compound…”
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