Search Results - "Zsebo, Krisztina M"

Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial by Greenberg, Barry, Prof, Butler, Javed, Prof, Felker, G Michael, Prof, Ponikowski, Piotr, Prof, Voors, Adriaan A, Prof, Desai, Akshay S, MD, Barnard, Denise, Prof, Bouchard, Alain, MD, Jaski, Brian, MD, Lyon, Alexander R, MD, Pogoda, Janice M, PhD, Rudy, Jeffrey J, BS, Zsebo, Krisztina M, PhD

“…Summary Background Sarcoplasmic/endoplasmic reticulum Ca2+ -ATPase (SERCA2a) activity is deficient in the failing heart. Correction of this abnormality by gene…”
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Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders by Kang, Soojeong, Dahl, Russell, Hsieh, Wilson, Shin, Andrew, Zsebo, Krisztina M., Buettner, Christoph, Hajjar, Roger J., Lebeche, Djamel

“…Dysregulation of endoplasmic reticulum (ER) Ca2+ homeostasis triggers ER stress leading to the development of insulin resistance in obesity and diabetes…”
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Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID Trial), a First-in-Human Phase 1/2 Clinical Trial by Jaski, Brian E., MD, FACC, Jessup, Mariell L., MD, Mancini, Donna M., MD, Cappola, Thomas P., MD, Pauly, Daniel F., MD, PhD, Greenberg, Barry, MD, Borow, Kenneth, MD, Dittrich, Howard, MD, Zsebo, Krisztina M., PhD, Hajjar, Roger J., MD

“…Abstract Background SERCA2a deficiency is commonly seen in advanced heart failure (HF). This study is designed to investigate safety and biological effects of…”
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Stem Cell Factor Gene Transfer Promotes Cardiac Repair After Myocardial Infarction via In Situ Recruitment and Expansion of c-kit+ Cells by Yaniz-Galende, Elisa, Chen, Jiqiu, Chemaly, Elie, Liang, Lifan, Hulot, Jean-Sebastien, McCollum, LaTronya, Arias, Teresa, Fuster, Valentin, Zsebo, Krisztina M, Hajjar, Roger J

“…RATIONALE:There is growing evidence that the myocardium responds to injury by recruiting c-kit cardiac progenitor cells to the damage tissue. Even though the…”
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Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells by Gruber, Simon J, Cornea, Razvan L, Li, Ji, Peterson, Kurt C, Schaaf, Tory M, Gillispie, Gregory D, Dahl, Russell, Zsebo, Krisztina M, Robia, Seth L, Thomas, David D

“…We have used a "two-color" SERCA (sarco/endoplasmic reticulum calcium ATPase) biosensor and a unique high-throughput fluorescence lifetime plate reader…”
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High-throughput FRET assay yields allosteric SERCA activators by Cornea, Razvan L, Gruber, Simon J, Lockamy, Elizabeth L, Muretta, Joseph M, Jin, Dongzhu, Chen, Jiqiu, Dahl, Russell, Bartfai, Tamas, Zsebo, Krisztina M, Gillispie, Gregory D, Thomas, David D

“…Using fluorescence resonance energy transfer (FRET), we performed a high-throughput screen (HTS) in a reconstituted membrane system, seeking compounds that…”
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Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A Phase 2 Trial of Intracoronary Gene Therapy of Sarcoplasmic Reticulum Ca2+-ATPase in Patients With Advanced Heart Failure by JESSUP, Mariell, GREENBERG, Barry, MANCINI, Donna, CAPPOLA, Thomas, PAULY, Daniel F, JASKI, Brian, YAROSHINSKY, Alex, ZSEBO, Krisztina M, DITTRICH, Howard, HAJJAR, Roger J

“…Adeno-associated virus type 1/sarcoplasmic reticulum Ca(2+)-ATPase was assessed in a randomized, double-blind, placebo-controlled, phase 2 study in patients…”
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Design of a phase 2b trial of intracoronary administration of AAV1/SERCA2a in patients with advanced heart failure: the CUPID 2 trial (calcium up-regulation by percutaneous administration of gene therapy in cardiac disease phase 2b) by Greenberg, Barry, Yaroshinsky, Alex, Zsebo, Krisztina M, Butler, Javed, Felker, G Michael, Voors, Adriaan A, Rudy, Jeffrey J, Wagner, Kim, Hajjar, Roger J

“…Impaired cardiac isoform of sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) activity is a key abnormality in heart failure patients with reduced ejection…”
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CUPID 2: A Phase 2b Trial Investigating the Efficacy and Safety of the Intracoronary Administration of AAV1/SERCA2a in Patients with Advanced Heart Failure by Greenberg, Barry, MD, Butler, Javed, MD, MPH, Felker, G. Michael, MD, MHS, Ponikowski, Piotr, MD, PhD, Voors, Adriaan A., MD, PhD, Jaski, Brian, MD, Lyon, Alexander R, Pogoda, Janice M., PhD, Rudy, Jeffrey J, Zsebo, Krisztina M., PhD

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CUPID 1: MYDICAR® in Patients With Advanced Heart Failure Continue to Demonstrate Improvement in Clinical Outcomes Compared to Optimal Therapy 9 Months Post-Dose by Greenberg, Barry, MD, Jessup, Mariell L., MD, Zsebo, Krisztina M., PhD, Yaroshinsky, Alex, PhD, Hajjar, Roger J., MD

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Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart Failure by Greenberg, Barry, MD, Yaroshinsky, Alex, PhD, Zsebo, Krisztina M., PhD, Butler, Javed, MD, MPH, Felker, G. Michael, MD, Voors, Adriaan A., MD, Rudy, Jeffrey J., BS, Wagner, Kim, MA, Hajjar, Roger J., MD

“…Objectives Impaired cardiac isoform of sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity is a key abnormality in heart failure patients with reduced…”
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Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver--conditioned medium by Zsebo, K M, Wypych, J, McNiece, I K, Lu, H S, Smith, K A, Karkare, S B, Sachdev, R K, Yuschenkoff, V N, Birkett, N C, Williams, L R

“…We have identified a novel growth factor, stem cell factor (SCF), for primitive hematopoietic progenitors based on its activity on bone marrow cells derived…”
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Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor by TOKSOZ, D, ZSEBO, K. M, SMITH, K. A, HU, S, BRANKOW, D, SUGGS, S. V, MARTIN, F. H, WILLIAMS, D. A

“…The maintenance and differentiation of hematopoietic stem cells is influenced by cells making up the hematopoietic microenvironment (HM), including bone…”
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Antigen-Specific Cytolysis by Neutrophils and NK Cells Expressing Chimeric Immune Receptors Bearing {zeta} or {gamma} Signaling Domains by Roberts, Margo R, Cooke, Keegan S, Tran, Annie-Chen, Smith, Kent A, Lin, Wei Yu, Wang, Martin, Dull, Thomas J, Farson, Deborah, Zsebo, Krisztina M, Finer, Mitchell H

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Recombinant Human Granulocyte Colony-Stimulating Factor: Effects on Normal and Leukemic Myeloid Cells by Souza, Lawrence M., Boone, Thomas C., Gabrilove, Janice, Lai, Por H., Zsebo, Krisztina M., Murdock, Douglas C, Chazin, Vicki R., Bruszewski, Joan, Lu, Hsieng, Chen, Kenneth K., Barendt, Jean, Platzer, Erich, Moore, Malcolm A. S., Mertelsmann, Roland, Welte, Karl

“…Experiments were conducted to isolate and characterize the gene and gene product of a human hematopoietic colony-stimulating factor with pluripotent biological…”
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Long-Term Generation of Colony-Forming Cells in Liquid Culture of CD34+ Cord Blood Cells in the Presence of Recombinant Human Stem Cell Factor by Giovanni, Migliaccio, Anna Rita, Migliaccio, Maurice, L. Druzin, Patricia-Jane, V. Giardina, Krisztina, M. Zsebo, John, W. Adamson

“…Human cord blood was used as a source of progenitor and stem cells to evaluate the effect of recombinant human stem-cell factor (SCF) on colony formation and…”
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Radioprotection of Mice by Recombinant Rat Stem Cell Factor by Zsebo, Krisztina M., Smith, Kent A., Hartley, Cynthia A., Greenblatt, Melvin, Cooke, Keegan, Rich, William, McNiece, Ian K.

“…Treatment with recombinant rat stem cell factor (rSCF) protects mice from the lethal effects of irradiation. Mice treated with a single dose of rSCF prior to…”
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Blasts From Patients With Acute Myelogenous Leukemia Express Functional Receptors for Stem Cell Factor by Broudy, Virginia C., Smith, Franklin O., Nancy, Lin, Krisztina, Zsebo M., Joan, Egrie, Irwin, Bernstein D.

“…Stem cell factor (SCF) acts in concert with lineage-specific growth factors to stimulate the growth of hematopoietic colonies. To determine if neoplastic human…”
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Murine mast cell colony formation supported by IL-3, IL-4, and recombinant rat stem cell factor, ligand for c-kit by Tsuji, K, Zsebo, K M, Ogawa, M

“…Recently, a novel cytokine designated stem cell factor (SCF) was isolated from medium conditioned by buffalo rat liver cells and proved to be the ligand for…”
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Measurement of human and murine stem cell factor (c-kit ligand) by Smith, Kent A, Zsebo, Krisztina M

“…Stem cell factor (SCF) is an early-acting, hematopoietic growth factor that binds to the receptor encoded by the proto-oncogene c-kit. It is a potent growth…”
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