Search Results - "Zschüntzsch, Jana"

Simultaneous assessment of lung morphology and respiratory motion in retrospectively gated in-vivo microCT of free breathing anesthetized mice by Dullin, Christian, Svetlove, Angelika, Zschüntzsch, Jana, Alves, Frauke

“…Retrospective gating (RG) is a well established technique in preclinical computed tomography (CT) to assess 3D morphology of the lung. In RG additional angular…”
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Scanning for Therapeutic Targets within the Cytokine Network of Idiopathic Inflammatory Myopathies by De Paepe, Boel, Zschüntzsch, Jana

“…The idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of chronic disorders that include dermatomyositis (DM), polymyositis (PM),…”
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Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study by Wilcke, Hannah, Glaubitz, Stefanie, Kück, Fabian, Anten, Christoph, Liebetanz, David, Schmidt, Jens, Zschüntzsch, Jana

“…Myasthenia gravis (MG) affects individuals as a chronic autoimmune disease for many years. Commonly, chronic diseases significantly reduce the patients'…”
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Non-invasive optoacoustic imaging of glycogen-storage and muscle degeneration in late-onset Pompe disease by Tan, Lina, Zschüntzsch, Jana, Meyer, Stefanie, Stobbe, Alica, Bruex, Hannah, Regensburger, Adrian P., Claßen, Merle, Alves, Frauke, Jüngert, Jörg, Rother, Ulrich, Li, Yi, Danko, Vera, Lang, Werner, Türk, Matthias, Schmidt, Sandy, Vorgerd, Matthias, Schlaffke, Lara, Woelfle, Joachim, Hahn, Andreas, Mensch, Alexander, Winterholler, Martin, Trollmann, Regina, Heiß, Rafael, Wagner, Alexandra L., Raming, Roman, Knieling, Ferdinand

“…Pompe disease (PD) is a rare autosomal recessive glycogen storage disorder that causes proximal muscle weakness and loss of respiratory function. While enzyme…”
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Description of Osmolyte Pathways in Maturing Mdx Mice Reveals Altered Levels of Taurine and Sodium/Myo-Inositol Co-Transporters by Merckx, Caroline, Cosemans, Gwenny, Zschüntzsch, Jana, Raedt, Robrecht, Schmidt, Jens, De Paepe, Boel, De Bleecker, Jan L

“…Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by progressive muscle degeneration. Osmotic stress participates to DMD pathology and…”
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Landscape analysis of available European data sources amenable for machine learning and recommendations on usability for rare diseases screening by Raycheva, Ralitsa, Kostadinov, Kostadin, Mitova, Elena, Iskrov, Georgi, Stefanov, Georgi, Vakevainen, Merja, Elomaa, Kaisa, Man, Yuen-Sum, Gross, Edith, Zschüntzsch, Jana, Röttger, Richard, Stefanov, Rumen

“…Patient registries and databases are essential tools for advancing clinical research in the area of rare diseases, as well as for enhancing patient care and…”
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Exploring the Therapeutic Potential of Ectoine in Duchenne Muscular Dystrophy: Comparison with Taurine, a Supplement with Known Beneficial Effects in the mdx Mouse by Merckx, Caroline, Zschüntzsch, Jana, Meyer, Stefanie, Raedt, Robrecht, Verschuere, Hanne, Schmidt, Jens, De Paepe, Boel, De Bleecker, Jan L.

“…Duchenne Muscular Dystrophy (DMD) is a debilitating muscle disorder that condemns patients to year-long dependency on glucocorticoids. Chronic glucocorticoid…”
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Treatment with human immunoglobulin G improves the early disease course in a mouse model of Duchenne muscular dystrophy by Zschüntzsch, Jana, Zhang, Yaxin, Klinker, Florian, Makosch, Gregor, Klinge, Lars, Malzahn, Dörthe, Brinkmeier, Heinrich, Liebetanz, David, Schmidt, Jens

“…Duchenne muscular dystrophy (DMD) is a severe hereditary myopathy. Standard treatment by glucocorticosteroids is limited because of numerous side effects. The…”
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Patient experiences of interprofessional collaboration and intersectoral communication in rare disease healthcare in Germany - a mixed-methods study by Inhestern, Laura, Otto, Ramona, Brandt, Maja, Zybarth, David, Oheim, Ralf, Schüler, Helke, Mir, Thomas S, Tsiakas, Konstantinos, Dibaj, Payam, Zschüntzsch, Jana, Okun, Pamela M, Hegenbart, Ute, Sommerburg, Olaf, Schramm, Christoph, Weiler-Normann, Christina, Härter, Martin, Bergelt, Corinna

“…Rare diseases are often complex, chronic and many of them life-shortening. In Germany, healthcare for rare diseases is organized in expert centers for rare…”
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Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy by Shahriyari, Mina, Islam, Md Rezaul, Sakib, Sadman M., Rinn, Malte, Rika, Anastasia, Krüger, Dennis, Kaurani, Lalit, Gisa, Verena, Winterhoff, Mandy, Anandakumar, Harithaa, Shomroni, Orr, Schmidt, Matthias, Salinas, Gabriela, Unger, Andreas, Linke, Wolfgang A., Zschüntzsch, Jana, Schmidt, Jens, Bassel‐Duby, Rhonda, Olson, Eric N., Fischer, André, Zimmermann, Wolfram‐Hubertus, Tiburcy, Malte

“…Background Human pluripotent stem cell‐derived muscle models show great potential for translational research. Here, we describe developmentally inspired…”
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Why Temporal Inference Stimulation May Fail in the Human Brain: A Pilot Research Study by Iszak, Krisztián, Gronemann, Simon Mathies, Meyer, Stefanie, Hunold, Alexander, Zschüntzsch, Jana, Bähr, Mathias, Paulus, Walter, Antal, Andrea

“…Temporal interference stimulation (TIS) aims at targeting deep brain areas during transcranial electrical alternating current stimulation (tACS) by generating…”
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HMGB1 and RAGE in skeletal muscle inflammation: Implications for protein accumulation in inclusion body myositis by Muth, Ingrid E., Zschüntzsch, Jana, Kleinschnitz, Konstanze, Wrede, Arne, Gerhardt, Ellen, Balcarek, Peter, Schreiber-Katz, Olivia, Zierz, Stephan, Dalakas, Marinos C., Voll, Reinhard E., Schmidt, Jens

“…Inflammation is associated with protein accumulation in IBM, but precise mechanisms are elusive. The “alarmin” HMGB1 is upregulated in muscle inflammation. Its…”
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The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease by Zschüntzsch, Jana, Meyer, Stefanie, Shahriyari, Mina, Kummer, Karsten, Schmidt, Matthias, Kummer, Susann, Tiburcy, Malte

“…Many neuromuscular disease entities possess a significant disease burden and therapeutic options remain limited. Innovative human preclinical models may help…”
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Evidence of Two Novel LAMA2 Variants in a Patient With Muscular Dystrophy: Facing the Challenges of a Certain Diagnosis by Meyer, Stefanie, Kaulfuß, Silke, Zechel, Sabrina, Kummer, Karsten, Seif Amir Hosseini, Ali, Ernst, Marielle Sophie, Schmidt, Jens, Pauli, Silke, Zschüntzsch, Jana

“…Background Benefits and challenges resulting from advances in genetic diagnostics are two sides of the same coin. Facilitation of a correct and timely…”
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In Vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS by Dibaj, Payam, Steffens, Heinz, Zschüntzsch, Jana, Nadrigny, Fabien, Schomburg, Eike D, Kirchhoff, Frank, Neusch, Clemens

“…Mutations in the enzyme superoxide dismutase-1 (SOD1) cause hereditary variants of the fatal motor neuronal disease Amyotrophic lateral sclerosis (ALS)…”
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Non-Invasive Optical Motion Tracking Allows Monitoring of Respiratory Dynamics in Dystrophin-Deficient Mice by Svetlove, Angelika, Albers, Jonas, Hülsmann, Swen, Markus, Marietta Andrea, Zschüntzsch, Jana, Alves, Frauke, Dullin, Christian

“…Duchenne muscular dystrophy (DMD) is the most common x-chromosomal inherited dystrophinopathy which leads to progressive muscle weakness and a premature death…”
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Long‐term human IgG treatment improves heart and muscle function in a mouse model of Duchenne muscular dystrophy by Zschüntzsch, Jana, Jouvenal, Pia Vanessa, Zhang, Yaxin, Klinker, Florian, Tiburcy, Malte, Liebetanz, David, Malzahn, Dörthe, Brinkmeier, Heinrich, Schmidt, Jens

“…Background Duchenne muscular dystrophy (DMD) is a progressive muscle‐wasting disease caused by mutations in the dystrophin gene, which leads to structural…”
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Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS by Dibaj, Payam, Zschüntzsch, Jana, Steffens, Heinz, Scheffel, Jörg, Göricke, Bettina, Weishaupt, Jochen H, Le Meur, Karim, Kirchhoff, Frank, Hanisch, Uwe-Karsten, Schomburg, Eike D, Neusch, Clemens

“…Mutations in SOD1 cause hereditary variants of the fatal motor neuron disease amyotrophic lateral sclerosis (ALS). Pathophysiology of the disease is…”
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Muscle Sonography in Inclusion Body Myositis: A Systematic Review and Meta-Analysis of 944 Measurements by Abdelnaby, Ramy, Mohamed, Khaled Ashraf, Elgenidy, Anas, Sonbol, Yousef Tarek, Bedewy, Mahmoud Mostafa, Aboutaleb, Aya Moustafa, Ebrahim, Mohamed Ayman, Maallem, Imene, Dardeer, Khaled Tarek, Heikal, Hamed Amr, Gawish, Hazem Maher, Zschüntzsch, Jana

“…Inclusion body myositis (IBM) is a slowly progressive muscle weakness of distal and proximal muscles, which is diagnosed by clinical and histopathological…”
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Induction of Osmolyte Pathways in Skeletal Muscle Inflammation: Novel Biomarkers for Myositis by De Paepe, Boel, Zschüntzsch, Jana, Šokčević, Tea, Weis, Joachim, Schmidt, Jens, De Bleecker, Jan L

“…We recently identified osmolyte accumulators as novel biomarkers for chronic skeletal muscle inflammation and weakness, but their precise involvement in…”
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