A comparison of 3-day and daily follicle-stimulating hormone injections on stimulation days 1-6 in women undergoing controlled ovarian hyperstimulation

To evaluate the efficacy of ovarian hyperstimulation by intermittent doses of 450 IU of recombinant human (h)FSH compared with daily 150-IU doses of recombinant hFSH. A pilot, open, randomized, parallel-group study. Center for Reproductive Medicine, Düsseldorf, Germany. Infertile women with indicati...

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Bibliographic Details
Published in:	Fertility and sterility Vol. 81; no. 4; p. 996
Main Authors:	Scholtes, Michael C W, Schnittert, Bettina, van Hoogstraten, Dagmar, Verhoeven, Hugo C, Zrener, Andrea, Warne, David W
Format:	Journal Article
Language:	English
Published:	United States 01-04-2004
Subjects:	Adult Dose-Response Relationship, Drug Drug Administration Schedule Embryo Implantation Female Follicle Stimulating Hormone - administration & dosage Hormones - administration & dosage Humans Injections, Subcutaneous Ovulation Induction Pregnancy Pregnancy Rate Recombinant Proteins - administration & dosage
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Summary:	To evaluate the efficacy of ovarian hyperstimulation by intermittent doses of 450 IU of recombinant human (h)FSH compared with daily 150-IU doses of recombinant hFSH. A pilot, open, randomized, parallel-group study. Center for Reproductive Medicine, Düsseldorf, Germany. Infertile women with indication for IVF/intracytoplasmic sperm injection after at least 1 year of unprotected intercourse. Recombinant hFSH was administered daily or intermittently (3-day intervals) from days 1 to 6 of stimulation and thereafter by daily injection. Number of preovulatory follicles, retrieved oocytes, two-pronuclei (2PN) zygotes, implantation, and pregnancy rates. The number of oocytes in the daily-dose group was significantly greater. There were no significant differences in mean values for number of follicles > or =11 mm (except for day 7) and > or =14 mm, 2PN zygotes, and number of transferred embryos. Implantation and pregnancy rates per cycle were in favor of the intermittent 450-IU dose regimen; implantation rates were 17.0% and 9.8% in the 3-day-dose and daily-dose groups, respectively, and biochemical and clinical pregnancy rates were 33.3% and 15.7% and 25.5% and 13.7%, respectively. Intermittent administration of recombinant hFSH significantly reduces the total number of recombinant hFSH injections, compared with a conventional FSH regimen, without detrimental effects on implantation rate or pregnancy rate.
ISSN:	0015-0282
DOI:	10.1016/j.fertnstert.2003.09.043