Search Results - "Zovo, Kairit"

Formation of [4Fe-4S] Clusters in the Mitochondrial Iron–Sulfur Cluster Assembly Machinery by Brancaccio, Diego, Gallo, Angelo, Mikolajczyk, Maciej, Zovo, Kairit, Palumaa, Peep, Novellino, Ettore, Piccioli, Mario, Ciofi-Baffoni, Simone, Banci, Lucia

“…The generation of [4Fe-4S] clusters in mitochondria critically depends, in both yeast and human cells, on two A-type ISC proteins (in mammals named ISCA1 and…”
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Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS) by Banci, Lucia, Bertini, Ivano, Cantini, Francesca, Kozyreva, Tatiana, Massagni, Chiara, Palumaa, Peep, Rubino, Jeffrey T, Zovo, Kairit

“…Copper chaperone for superoxide dismutase 1 (SOD1), CCS, is the physiological partner for the complex mechanism of SOD1 maturation. We report an in vitro model…”
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Substitution of the Methionine Axial Ligand of the T1 Copper for the Fungal-like Phenylalanine Ligand (M298F) Causes Local Structural Perturbations that Lead to Thermal Instability and Reduced Catalytic Efficiency of the Small Laccase from Streptomyces coelicolor A3(2) by Zovo, Kairit, Pupart, Hegne, Van Wieren, Arie, Gillilan, Richard E, Huang, Qingqiu, Majumdar, Sudipta, Lukk, Tiit

“…Many industrial processes operate at elevated temperatures or within broad pH and salinity ranges. However, the utilization of enzymes to carry out…”
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Organization and Assembly of Metal-Thiolate Clusters in Epithelium-specific Metallothionein-4 by Meloni, Gabriele, Zovo, Kairit, Kazantseva, Jekaterina, Palumaa, Peep, Vašák, Milan

“…Mammalian metallothionein-4 (MT-4) was found to be specifically expressed in stratified squamous epithelia where it plays an essential but poorly defined role…”
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Affinity gradients drive copper to cellular destinations by Bertini, Ivano, Palumaa, Peep, Banci, Lucia, Ciofi-Baffoni, Simone, Kozyreva, Tatiana, Zovo, Kairit

“…Copper is an essential trace element for eukaryotes and most prokaryotes. However, intracellular free copper must be strictly limited because of its toxic side…”
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Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators by Tõugu, Vello, Karafin, Ann, Zovo, Kairit, Chung, Roger S, Howells, Claire, West, Adrian K, Palumaa, Peep

“…Aggregation of amyloid-β (Aβ) peptides is a central phenomenon in Alzheimer's disease. Zn(II) and Cu(II) have profound effects on Aβ aggregation; however,…”
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The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons by Chung, Roger S, Howells, Claire, Eaton, Emma D, Shabala, Lana, Zovo, Kairit, Palumaa, Peep, Sillard, Rannar, Woodhouse, Adele, Bennett, William R, Ray, Shannon, Vickers, James C, West, Adrian K

“…A major pathological hallmark of AD is the deposition of insoluble extracellular beta-amyloid (Abeta) plaques. There are compelling data suggesting that Abeta…”
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Modulation of redox switches of copper chaperone Cox17 by Zn(II) ions determined by new ESI MS-based approach by Zovo, Kairit, Palumaa, Peep

“…Cox17, a copper chaperone for cytochrome-c oxidase, contains six conserved Cys residues and exists in three oxidative states, linked with two thiol-based redox…”
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Label-Free High-Throughput Screening Assay for Inhibitors of Alzheimer’s Amyloid-β Peptide Aggregation Based on MALDI MS by Zovo, Kairit, Helk, Eneken, Karafin, Ann, Tõugu, Vello, Palumaa, Peep

“…Aggregation of amyloid-β (Aβ) peptides is causatively linked to Alzheimer’s disease (AD); thus, suppression of this process by small molecule inhibitors is a…”
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The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons by Chung, Roger S., Howells, Claire, Eaton, Emma D., Shabala, Lana, Zovo, Kairit, Palumaa, Peep, Sillard, Rannar, Woodhouse, Adele, Bennett, William R., Ray, Shannon, Vickers, James C., West, Adrian K.

“…Background A major pathological hallmark of AD is the deposition of insoluble extracellular β-amyloid (Aβ) plaques. There are compelling data suggesting that…”
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Effect of methionine-35 oxidation on the aggregation of amyloid-β peptide by Friedemann, Merlin, Helk, Eneken, Tiiman, Ann, Zovo, Kairit, Palumaa, Peep, Tõugu, Vello

“…Aggregation of Aβ peptides into amyloid plaques is considered to trigger the Alzheimer's disease (AD), however the mechanism behind the AD onset has remained…”
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Label-Free High-Throughput Screening Assay for Inhibitors of Alzheimer's Amyloid-[Beta] Peptide Aggregation Based on MALDI MS by Zovo, Kairit, Helk, Eneken, Karafin, Ann, Töugu, Vello, Palumaa, Peep

“…Aggregation of amyloid-β (Aβ) peptides is causatively linked to Alzheimer's disease (AD); thus, suppression of this process by small molecule inhibitors is a…”
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Oxidation of Methionine-35 in Alzheimer’s amyloid-beta peptide and the aggregation of the oxidized peptide by Friedemann, Merlin, Helk, Eneken, Tiiman, Ann, Zovo, Kairit, Palumaa, Peep, Tõugu, Vello

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Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-[beta] (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators by Tõugu, Vello, Karafin, Ann, Zovo, Kairit, Chung, Roger S, Howells, Claire, West, Adrian K, Palumaa, Peep

“…Aggregation of amyloid-β (Aβ) peptides is a central phenomenon in Alzheimer's disease. Zn(II) and Cu(II) have profound effects on Aβ aggregation; however,…”
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Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-b (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators by Tougu, Vello, Karafin, Ann, Zovo, Kairit, Chung, Roger S, Howells, Claire, West, Adrian K, Palumaa, Peep

“…AbstractAggregation of amyloid-b (Ab) peptides is a central phenomenon in Alzheimer's disease. Zn(II) and Cu(II) have profound effects on Ab aggregation;…”
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The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated A[beta] Aggregation and Toxicity in Rat Cortical Neurons by Chung, Roger S, Howells, Claire, Eaton, Emma D, Shabala, Lana, Zovo, Kairit, Palumaa, Peep, Sillard, Rannar, Woodhouse, Adele, Bennett, William R, Ray, Shannon, Vickers, James C, West, Adrian K

“…Background A major pathological hallmark of AD is the deposition of insoluble extracellular [beta]-amyloid (A[beta]) plaques. There are compelling data…”
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The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Ab Aggregation and Toxicity in Rat Cortical Neurons by Chung, Roger S, Howells, Claire, Eaton, Emma D, Shabala, Lana, Zovo, Kairit, Palumaa, Peep, Sillard, Rannar, Woodhouse, Adele, Bennett, William R, Ray, Shannon, Vickers, James C, West, Adrian K

“…A major pathological hallmark of AD is the deposition of insoluble extracellular b-amyloid (Ab) plaques. There are compelling data suggesting that Ab…”
Get full text