Search Results - "Zovein, Ann C"

Fate tracing reveals the endothelial origin of hematopoietic stem cells by Zovein, Ann C, Hofmann, Jennifer J, Lynch, Maureen, French, Wendy J, Turlo, Kirsten A, Yang, Yanan, Becker, Michael S, Zanetta, Lucia, Dejana, Elisabetta, Gasson, Judith C, Tallquist, Michelle D, Iruela-Arispe, M Luisa

“…Hematopoietic stem cells (HSCs) originate within the aortic-gonado-mesonephros (AGM) region of the midgestation embryo, but the cell type responsible for their…”
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Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition by Lizama, Carlos O., Hawkins, John S., Schmitt, Christopher E., Bos, Frank L., Zape, Joan P., Cautivo, Kelly M., Borges Pinto, Hugo, Rhyner, Alexander M., Yu, Hui, Donohoe, Mary E., Wythe, Joshua D., Zovein, Ann C.

“…Changes in cell fate and identity are essential for endothelial-to-haematopoietic transition (EHT), an embryonic process that generates the first adult…”
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SOX2 regulates acinar cell development in the salivary gland by Emmerson, Elaine, May, Alison J, Nathan, Sara, Cruz-Pacheco, Noel, Lizama, Carlos O, Maliskova, Lenka, Zovein, Ann C, Shen, Yin, Muench, Marcus O, Knox, Sarah M

“…Acinar cells play an essential role in the secretory function of exocrine organs. Despite this requirement, how acinar cells are generated during organogenesis…”
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Single-cell resolution of morphological changes in hemogenic endothelium by Bos, Frank L, Hawkins, John S, Zovein, Ann C

“…Endothelial-to-hematopoietic transition (EHT) occurs within a population of hemogenic endothelial cells during embryogenesis, and leads to the formation of the…”
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Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice by Jiang, Xuan, Hawkins, John S., Lee, Jerry, Lizama, Carlos O., Bos, Frank L., Zape, Joan P., Ghatpande, Prajakta, Peng, Yongbo, Louie, Justin, Lagna, Giorgio, Zovein, Ann C., Hata, Akiko

“…Hematopoietic stem and progenitor cells arise from the vascular endothelium of the dorsal aorta and subsequently switch niche to the fetal liver through…”
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Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription by Koh, Fong Ming, Lizama, Carlos O., Wong, Priscilla, Hawkins, John S., Zoveind, Ann C., Ramalho-Santos, Miguel

“…Significance Adult hematopoietic stem and progenitor cells (HSPCs) develop from a small number of specialized endothelial cells in the embryo. Very little is…”
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VE‐Cadherin‐Cre‐recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells by Alva, Jackelyn A., Zovein, Ann C., Monvoisin, Arnaud, Murphy, Thomas, Salazar, Anthony, Harvey, Natasha L., Carmeliet, Peter, Iruela‐Arispe, M. Luisa

“…The ability to target gene deletion to a specific cellular compartment via the Cre/loxP system has been a powerful tool in the analysis of broadly expressed…”
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Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models by Cristofaro, Brunella, Shi, Yu, Faria, Marcella, Suchting, Steven, Leroyer, Aurelie S, Trindade, Alexandre, Duarte, Antonio, Zovein, Ann C, Iruela-Arispe, M Luisa, Nih, Lina R, Kubis, Nathalie, Henrion, Daniel, Loufrani, Laurent, Todiras, Mihail, Schleifenbaum, Johanna, Gollasch, Maik, Zhuang, Zhen W, Simons, Michael, Eichmann, Anne, le Noble, Ferdinand

“…Arteriogenesis requires growth of pre-existing arteriolar collateral networks and determines clinical outcome in arterial occlusive diseases. Factors…”
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Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters by Zovein, Ann C., Turlo, Kirsten A., Ponec, Ryan M., Lynch, Maureen R., Chen, Kevin C., Hofmann, Jennifer J., Cox, Timothy C., Gasson, Judith C., Iruela-Arispe, M. Luisa

“…The vitelline artery is a temporary structure that undergoes extensive remodeling during midgestation to eventually become the superior mesenteric artery (also…”
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From transplantation to transgenics: Mouse models of developmental hematopoiesis by Schmitt, Christopher E, Lizama, Carlos O, Zovein, Ann C

“…The mouse is integral to our understanding of hematopoietic biology. Serving as a mammalian model system, the mouse has allowed for the discovery of…”
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Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming by Schmitt, Christopher E, Morales, Blanca M, Schmitz, Ellen M H, Hawkins, John S, Lizama, Carlos O, Zape, Joan P, Hsiao, Edward C, Zovein, Ann C

“…Non-integrating episomal vectors have become an important tool for induced pluripotent stem cell reprogramming. The episomal vectors carrying the "Yamanaka…”
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Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome by Hofmann, Jennifer J, Zovein, Ann C, Koh, Huilin, Radtke, Freddy, Weinmaster, Gerry, Iruela-Arispe, M Luisa

“…Mutations in the human Notch ligand jagged 1 (JAG1) result in a multi-system disorder called Alagille syndrome (AGS). AGS is chiefly characterized by a paucity…”
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NOTCH1 is a mechanosensor in adult arteries by Mack, Julia J., Mosqueiro, Thiago S., Archer, Brian J., Jones, William M., Sunshine, Hannah, Faas, Guido C., Briot, Anais, Aragón, Raquel L., Su, Trent, Romay, Milagros C., McDonald, Austin I., Kuo, Cheng-Hsiang, Lizama, Carlos O., Lane, Timothy F., Zovein, Ann C., Fang, Yun, Tarling, Elizabeth J., de Aguiar Vallim, Thomas Q., Navab, Mohamad, Fogelman, Alan M., Bouchard, Louis S., Iruela-Arispe, M. Luisa

“…Endothelial cells transduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis. Here we show that endothelial…”
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Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction by Arnold, Thomas D, Lizama, Carlos O, Cautivo, Kelly M, Santander, Nicolas, Lin, Lucia, Qiu, Haiyan, Huang, Eric J, Liu, Chang, Mukouyama, Yoh-Suke, Reichardt, Louis F, Zovein, Ann C, Sheppard, Dean

“…Microglia play a pivotal role in the coordination of brain development and have emerged as a critical determinant in the progression of neurodegenerative…”
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Polarizing pathways: Balancing endothelial polarity, permeability, and lumen formation by Lizama, Carlos O., Zovein, Ann C.

“…•Key molecules known to regulate endothelial permeability also control polarity.•Complexes required for apical–basal polarity remain critical for lumen…”
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β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism by Zovein, Ann C., Luque, Alfonso, Turlo, Kirsten A., Hofmann, Jennifer J., Yee, Kathleen M., Becker, Michael S., Fassler, Reinhard, Mellman, Ira, Lane, Timothy F., Iruela-Arispe, M. Luisa

“…Maintenance of single-layered endothelium, squamous endothelial cell shape, and formation of a patent vascular lumen all require defined endothelial cell…”
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Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome by Hofmann, Jennifer J, Briot, Anais, Enciso, Josephine, Zovein, Ann C, Ren, Shuxun, Zhang, Zhen W, Radtke, Freddy, Simons, Michael, Wang, Yibin, Iruela-Arispe, M Luisa

“…The Notch signaling pathway is an important contributor to the development and homeostasis of the cardiovascular system. Not surprisingly, mutations in Notch…”
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Differential Etv2 threshold requirement for endothelial and erythropoietic development by Sinha, Tanvi, Lammerts van Bueren, Kelly, Dickel, Diane E., Zlatanova, Ivana, Thomas, Reuben, Lizama, Carlos O., Xu, Shan-Mei, Zovein, Ann C., Ikegami, Kohta, Moskowitz, Ivan P., Pollard, Katherine S., Pennacchio, Len A., Black, Brian L.

“…Endothelial and erythropoietic lineages arise from a common developmental progenitor. Etv2 is a master transcriptional regulator required for the development…”
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Hemogenic endothelium: Origins, regulation, and implications for vascular biology by Zape, Joan P., Zovein, Ann C.

“…► The bipotential hemangioblast paradigm has shifted to “hemogenic endothelium”. ► Hematopoietic stem cell (HSC) embryonic origins can be traced to specialized…”
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Cell cycle dynamics and complement expression distinguishes mature haematopoietic subsets arising from hemogenic endothelium by Zape, Joan P, Lizama, Carlos O, Cautivo, Kelly M, Zovein, Ann C

“…The emergence of haematopoietic stem and progenitor cells (HSPCs) from hemogenic endothelium results in the formation of sizeable HSPC clusters attached to the…”
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