Search Results - "Zou, Ming"

AMPK, Mitochondrial Function, and Cardiovascular Disease by Wu, Shengnan, Zou, Ming-Hui

“…Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous catabolic and anabolic signaling pathways to sustain appropriate intracellular…”
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Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation by Wang, Qiongxin, Liu, Danxia, Song, Ping, Zou, Ming-Hui

“…The kynurenine (Kyn) pathway is the major route for tryptophan (Trp) metabolism, and it contributes to several fundamental biological processes. Trp is…”
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Measurement of Reactive Oxygen Species (ROS) and Mitochondrial ROS in AMPK Knockout Mice Blood Vessels by Wang, Qilong, Zou, Ming-Hui

“…Reactive oxygen species (ROS) are a group of unstable and highly reactive molecules or free radicals typically generated as by-products of cellular processes…”
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β-hydroxybutyrate and its metabolic effects on age-associated pathology by Han, Young-Min, Ramprasath, Tharmarajan, Zou, Ming-Hui

“…Aging is a universal process that renders individuals vulnerable to many diseases. Although this process is irreversible, dietary modulation and caloric…”
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Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases by Song, Ping, Ramprasath, Tharmarajan, Wang, Huan, Zou, Ming-Hui

“…Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most mammalian cells. The KP generates several bioactive catabolites, such as…”
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Targeting senescent cells to attenuate cardiovascular disease progression by Song, Ping, Zhao, Qiang, Zou, Ming-Hui

“…[Display omitted] •Cardiovascular cell senescence is distinct from quiescence.•Senescent cardiovascular cells contribute to various disease development and…”
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Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission by Wang, Qilong, Zhang, Miao, Torres, Gloria, Wu, Shengnan, Ouyang, Changhan, Xie, Zhonglin, Zou, Ming-Hui

“…Metformin is a widely used antidiabetic drug that exerts cardiovascular protective effects in patients with diabetes. How metformin protects against…”
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Mitochondrial ROS and cancer drug resistance: Implications for therapy by Okon, Imoh S., Zou, Ming-Hui

“…At the heart of processes that contribute to cancer drug resistance is mitochondrial ROS which impact enzyme activity and function, genetic instability, as…”
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Activation of AMP‐activated protein kinase by metformin ablates angiotensin II‐induced endoplasmic reticulum stress and hypertension in mice in vivo by Duan, Quanlu, Song, Ping, Ding, Ye, Zou, Ming‐Hui

“…Background and Purpose Metformin, one of the most frequently prescribed medications for type 2 diabetes, reportedly exerts BP‐lowering effects in patients with…”
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Oxidative Stress, GTPCH1, and Endothelial Nitric Oxide Synthase Uncoupling in Hypertension by Wu, Yin, Ding, Ye, Ramprasath, Tharmarajan, Zou, Ming-Hui

“…Hypertension has major health consequences, which is associated with endothelial dysfunction. Endothelial nitric oxide synthase (eNOS)-produced nitric oxide…”
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Dissociation of Bcl-2―Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes by CHAOYONG HE, HUAIPING ZHU, HONGLIANG LI, ZOU, Ming-Hui, ZHONGLIN XIE

“…Diabetic cardiomyopathy is associated with suppression of cardiac autophagy, and activation of AMP-activated protein kinase (AMPK) restores cardiac autophagy…”
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Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis by Lu, Qiulun, Ma, Zejun, Ding, Ye, Bedarida, Tatiana, Chen, Liming, Xie, Zhonglin, Song, Ping, Zou, Ming-Hui

“…Although angiotensin II (AngII) is known to cause renal injury and fibrosis, the underlying mechanisms remain poorly characterized. Here we show that…”
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BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1/Parkin-mediated mitophagy in vivo by Mu, Jing, Zhang, Donghong, Tian, Yunli, Xie, Zhonglin, Zou, Ming-hui

“…BRD4 is a member of the BET family of epigenetic regulators. Inhibition of BRD4 by the selective bromodomain inhibitor JQ1, alleviates thoracic aortic…”
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Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction by JIAN XU, ZOU, Ming-Hui

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Binding of FUN14 Domain Containing 1 With Inositol 1,4,5-Trisphosphate Receptor in Mitochondria-Associated Endoplasmic Reticulum Membranes Maintains Mitochondrial Dynamics and Function in Hearts in Vivo by Wu, Shengnan, Lu, Qiulun, Wang, Qilong, Ding, Ye, Ma, Zejun, Mao, Xiaoxiang, Huang, Kai, Xie, Zhonglin, Zou, Ming-Hui

“…BACKGROUND:FUN14 domain containing 1 (FUNDC1) is a highly conserved outer mitochondrial membrane protein. The aim of this study is to examine whether FUNDC1…”
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Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases by Song, Ping, An, Junqing, Zou, Ming-Hui

“…Senescent cells are generally characterized by permanent cell cycle arrest, metabolic alteration and activation, and apoptotic resistance in multiple organs…”
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AMP-activated protein kinase, stress responses and cardiovascular diseases by Wang, Shaobin, Song, Ping, Zou, Ming-Hui

“…AMPK (AMP-activated protein kinase) is one of the key players in maintaining intracellular homoeostasis. AMPK is well known as an energy sensor and can be…”
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Macrophage Liver Kinase B1 Inhibits Foam Cell Formation and Atherosclerosis by Liu, Zhaoyu, Zhu, Huaiping, Dai, Xiaoyan, Wang, Cheng, Ding, Ye, Song, Ping, Zou, Ming-Hui

“…RATIONALE:LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regulates the homeostasis of hematopoietic cells and immune…”
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Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems by Song, Ping, Zou, Ming-Hui

“…Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are ubiquitously produced in cardiovascular systems. Under physiological conditions, ROS/RNS…”
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MicroRNA and cancer: Current status and prospective by Wu, Wei, Sun, Miao, Zou, Gang‐Ming, Chen, Jianjun

“…Gene expression in normal cells is highly regulated by complex gene regulatory networks. Disruption of these networks may lead to cancer. Recent studies have…”
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