Search Results - "Zou, Hongye"

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype by Cai, Demin, Wang, Junjian, Gao, Bei, Li, Jin, Wu, Feng, Zou, June X., Xu, Jianzhen, Jiang, Yuqian, Zou, Hongye, Huang, Zenghong, Borowsky, Alexander D., Bold, Richard J., Lara, Primo N., Li, Jian Jian, Chen, Xinbin, Lam, Kit S., To, Ka-Fai, Kung, Hsing-Jien, Fiehn, Oliver, Zhao, Ruqian, Evans, Ronald M., Chen, Hong-Wu

“…Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC)…”
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Natural compounds ursolic acid and digoxin exhibit inhibitory activities to cancer cells in RORγ-dependent and -independent manner by Zou, Hongye, Yang, Yatian, Chen, Hong-Wu

“…Natural compounds ursolic acid (UA) and digoxin isolated from fruits and other plants display potent anti-cancer effects in preclinical studies. UA and digoxin…”
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A Single Enhanced Dual-Energy CT Scan May Distinguish Lung Squamous Cell Carcinoma From Adenocarcinoma During the Venous phase by Zhang, Zhaotao, Zou, Hongye, Yuan, Aimei, Jiang, Fei, Zhao, Baolin, Liu, Yin, Chen, Jinghua, Zuo, Minjing, Gong, Lianggeng

“…To investigate whether iodine quantification extracted from enhanced dual energy-computed tomography (DE-CT) is useful for distinguishing lung squamous cell…”
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A mitochondria-targeting lipid–small molecule hybrid nanoparticle for imaging and therapy in an orthotopic glioma model by Tang, Menghuan, Lin, Kai, Ramachandran, Mythili, Li, Longmeng, Zou, Hongye, Zheng, Huzhi, Ma, Zhao, Li, Yuanpei

“…Hybrid lipid‒nanoparticle complexes have shown attractive characteristics as drug carriers due to their integrated advantages from liposomes and nanoparticles…”
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Preparation of palladium membrane by bio-membrane assisted electroless plating for hydrogen separation by Guo, Yu, Zou, Hongye, Wu, Hongmei, Zhou, Lidai, Liu, Haiou, Zhang, Xiongfu

“…Palladium membrane was prepared on the inner surface of alumina tube by bio-membrane assisted electroless plating combined with osmosis method (BELP). In this…”
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Targeting castration-resistant prostate cancer with a novel RORγ antagonist elaiophylin by Zheng, Jianwei, Wang, Junfeng, Wang, Qian, Zou, Hongye, Wang, Hong, Zhang, Zhenhua, Chen, Jianghe, Wang, Qianqian, Wang, Panxia, Zhao, Yueshan, Lu, Jing, Zhang, Xiaolei, Xiang, Songtao, Wang, Haibin, Lei, Jinping, Chen, Hong-Wu, Liu, Peiqing, Liu, Yonghong, Han, Fanghai, Wang, Junjian

“…Prostate cancer (PCa) patients who progress to metastatic castration-resistant PCa (mCRPC) mostly have poor outcomes due to the lack of effective therapies…”
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RORγ is a context-specific master regulator of cholesterol biosynthesis and an emerging therapeutic target in cancer and autoimmune diseases by Zou, Hongye, Yang, Nianxin, Zhang, Xiong, Chen, Hong-Wu

“…[Display omitted] Aberrant cholesterol metabolism and homeostasis in the form of elevated cholesterol biosynthesis and dysregulated efflux and metabolism is…”
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A Study of the Function of RORγ in Cancer Using Synthetic and Natural Small-Molecule Modulators by Zou, Hongye

“…Nuclear receptor RAR-related orphan receptor gamma (RORγ) and its isoform RORγt are major transcriptional regulators in control of mammalian metabolism,…”
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Nuclear receptor RORγ inverse agonists/antagonists display tissue- and gene-context selectivity through distinct activities in altering chromatin accessibility and master regulator SREBP2 occupancy by Zou, Hongye, Yang, Yatian, Shi, Zhenrui, Wu, Xuesong, Liu, Ruiwu, Yu, Ai-Ming, Chen, Hong-Wu

“…The nuclear receptor RORγ is a major driver of autoimmune diseases and certain types of cancer due to its aberrant function in T helper 17 (Th17) cell…”
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Value of Cardiac Magnetic Resonance Fractal Analysis Combined With Myocardial Strain in Discriminating Isolated Left Ventricular Noncompaction and Dilated Cardiomyopathy by Zheng, Tian, Ma, Xiaohai, Li, Shuhao, Ueda, Takuya, Wang, Zheng, Lu, Aijia, Zhou, Wei, Zou, Hongye, Zhao, Lei, Gong, Lianggeng

“…Background Excessive trabeculation is present in isolated left ventricular noncompaction (LVNC) and dilated cardiomyopathy (DCM), which sometimes makes the…”
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Abstract 4918: Natural compounds ursolic acid and digoxin exhibit anti-cancer effects through nuclear receptor RORγ-dependent and -independent mechanisms by Zou, Hongye, Yang, Yatian, Cai, Demin, Chen, Hong-Wu

“…Abstract Natural compounds such as ursolic acid (UA) and digoxin isolated from fruits and other plants display potent anti-cancer effects in preclinical…”
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Growth inhibition of breast cancer by two flexible heteroarotinoid enantiomers by Ginn, Emily, Baek, Jenny, Zou, Hongye, Fallatah, Maryam M.J., Cayton, Erica, Liu, Shengquan, Louie, Maggie

“…Flexible heteroarotinoid (flex‐hets) are compounds that show promising anti‐cancerous activities. More specifically, SHetA2, a first generation Flex‐Het, has…”
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Abstract 2090: Targeting estrogen receptor negative breast cancer cells using diarylthiourea analogs of SHetA2 by Zou, Hongye, Ginn, Emily, Francis, Sabah M., Liu, Shengquan, Louie, Maggie

“…Abstract Breast cancer is one of the most common cancers that occur in women in the United States. Depending on the expression of estrogen receptor α (ERα),…”
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Abstract 113: Evaluating the anticancer activity of two flexible heteroarotinoid analogs on breast cancer by Ginn, Emily, Zou, Hongye, Fallatah, Maryam M., Liu, Shengquan, Louie, Maggie C.

“…Abstract Flexible heteroarotiniods (flex-hets) are compounds derived from retinoic acid and recent studies have indicated that these compounds exhibit…”
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Novel flexible heteroarotinoid, SL-1-39, inhibits HER2-positive breast cancer cell proliferation by promoting lysosomal degradation of HER2 by Zou, Hongye, Sevigny, Mary B., Liu, Shengquan, Madden, David T., Louie, Maggie C.

“…SL-1-39 [1-(4-chloro-3-methylphenyl)-3-(4-nitrophenyl)thiourea] is a new flexible heteroarotinoid (Flex-Het) analog derived from the parental compound, SHetA2,…”
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Enantiomer of the novel flexible heteroarotinoid, SL-1-09, blocks cell cycle progression in breast cancer cells by Ginn, Emily, Baek, Jihyun, Zou, Hongye, Fallatah, Maryam M.J., Liu, Shengquan, Sevigny, Mary B., Louie, Maggie

“…Flexible heteroarotinoids (Flex-Hets) are compounds with promising anti-cancer activities. SHetA2, a first-generation Flex-Het, has been shown to inhibit the…”
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Novel flexible heteroarotinoid, SL-1-18, promotes ERα degradation to inhibit breast cancer cell growth by Fallatah, Maryam M., Liu, Shengquan, Sevigny, Mary B., Zou, Hongye, Louie, Maggie C.

“…SL-1-18 (1-(chrysen-6-yl)-3-(4-nitrophenyl)thiourea) is new flexible heteroarotinoid (Flex-Het) analog derived from the parent compound, SHetA2, and our…”
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Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma by Zheng, Jianwei, Wang, Qianqian, Chen, Jianghe, Cai, Guodi, Zhang, Zhenhua, Zou, Hongye, Zou, June X., Liu, Qianqian, Ji, Shufeng, Shao, Guoli, Li, Hong, Li, Sheng, Chen, Hong-Wu, Lu, LinLin, Yuan, Yanqiu, Liu, Peiqing, Wang, Junjian

“…Osteosarcoma (OS) is the most common malignant bone tumor with a poor prognosis. Here, we show that the nuclear receptor RORγ may serve as a potential…”
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