Search Results - "Zou, Chenhui"

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids by Hu, Huili, Gehart, Helmuth, Artegiani, Benedetta, LÖpez-Iglesias, Carmen, Dekkers, Florijn, Basak, Onur, van Es, Johan, Chuva de Sousa Lopes, Susana M., Begthel, Harry, Korving, Jeroen, van den Born, Maaike, Zou, Chenhui, Quirk, Corrine, Chiriboga, Luis, Rice, Charles M., Ma, Stephanie, Rios, Anne, Peters, Peter J., de Jong, Ype P., Clevers, Hans

“…The mammalian liver possesses a remarkable regenerative ability. Two modes of damage response have been described: (1) The “oval cell” response emanates from…”
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Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism by Qiao, Liping, Zou, Chenhui, van der Westhuyzen, Deneys R, Shao, Jianhua

“…Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism Liping Qiao 1 , Chenhui Zou 1 , Deneys R. van der Westhuyzen 1 2 and Jianhua…”
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Role of adipocytokines in obesity-associated insulin resistance by Zou, Chenhui, Shao, Jianhua

“…The rapid increase of obese population in the United States has made obesity into epidemic proportion. Obesity is a strong risk factor for metabolic syndrome,…”
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Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes by Michailidis, Eleftherios, Vercauteren, Koen, Mancio-Silva, Liliana, Andrus, Linda, Jahan, Cyprien, Ricardo-Lax, Inna, Zou, Chenhui, Kabbani, Mohammad, Park, Paul, Quirk, Corrine, Pyrgaki, Christina, Razooky, Brandon, Verhoye, Lieven, Zoluthkin, Irene, Lu, Wei-Yu, Forbes, Stuart J., Chiriboga, Luis, Theise, Neil D., Herzog, Roland W., Suemizu, Hiroshi, Schneider, William M., Shlomai, Amir, Meuleman, Philip, Bhatia, Sangeeta N., Rice, Charles M., de Jong, Ype P.

“…Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan…”
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Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis by La Bonte, Laura R, Pavlov, Vasile I, Tan, Ying S, Takahashi, Kazue, Takahashi, Minoru, Banda, Nirmal K, Zou, Chenhui, Fujita, Teizo, Stahl, Gregory L

“…Bleeding disorders and thrombotic complications constitute a major cause of death and disability worldwide. Although it is known that the complement and…”
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Human Mannose-Binding Lectin Inhibitor Prevents Myocardial Injury and Arterial Thrombogenesis in a Novel Animal Model by Pavlov, Vasile I, Tan, Ying S, McClure, Erin E, La Bonte, Laura R, Zou, Chenhui, Gorsuch, William B, Stahl, Gregory L

“…Myocardial infarction and coagulation disorders are leading causes of disability and death in the world. An important role of the lectin complement pathway in…”
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Linezolid-Resistant Enterococcus faecalis of Chicken Origin Harbored Chromosome-Borne optrA and Plasmid-Borne cfr , cfr (D), and poxtA2 Genes by Tang, Biao, Zou, Chenhui, Schwarz, Stefan, Xu, Chunyan, Hao, Wenbo, Yan, Xiao-Mei, Huang, Yuting, Ni, Juan, Yang, Hua, Du, Xiang-Dang, Shan, Xinxin

“…The aim of this study was to investigate the transferability of acquired linezolid resistance genes and associated mobile genetic elements in an Enterococcus…”
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Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice by Zou, Chenhui, Vercauteren, Koen O.A., Michailidis, Eleftherios, Kabbani, Mohammad, Zoluthkin, Irene, Quirk, Corrine, Chiriboga, Luis, Yazicioglu, Mustafa, Anguela, Xavier M., Meuleman, Philip, High, Katherine A., Herzog, Roland W., de Jong, Ype P.

“…Adeno-associated virus (AAV) vector serotypes vary in their ability to transduce hepatocytes from different species. Chimeric mouse models harboring human…”
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Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity by Biswas, Moanaro, Marsic, Damien, Li, Ning, Zou, Chenhui, Gonzalez-Aseguinolaza, Gloria, Zolotukhin, Irene, Kumar, Sandeep R.P., Rana, Jyoti, Butterfield, John S.S., Kondratov, Oleksandr, de Jong, Ype P., Herzog, Roland W., Zolotukhin, Sergei

“…Limitations to successful gene therapy with adeno-associated virus (AAV) can comprise pre-existing neutralizing antibodies to the vector capsid that can block…”
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Mouse characteristics that affect establishing xenografts from hepatocellular carcinoma patient biopsies in the United States by Zou, Chenhui, El Dika, Imane, Vercauteren, Koen O. A., Capanu, Marinela, Chou, Joanne, Shia, Jinru, Pilet, Jill, Quirk, Corrine, Lalazar, Gadi, Andrus, Linda, Kabbani, Mohammad, Yaqubie, Amin, Khalil, Danny, Mergoub, Taha, Chiriboga, Luis, Rice, Charles M., Abou‐Alfa, Ghassan K., de Jong, Ype P.

“…Background Hepatocellular carcinoma (HCC) patient‐derived xenograft (PDX) models hold potential to advance knowledge in HCC biology to help improve systemic…”
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Tandem amplification of a plasmid-borne tet(A) variant gene confers tigecycline resistance in Escherichia coli by Zou, Chenhui, Xu, Chunyan, Yu, Runhao, Shan, Xinxin, Schwarz, Stefan, Li, Dexi, Du, Xiang-Dang

“…To elucidate the mechanism of tigecycline resistance in Escherichia coli that is mediated by the tet(A) variant gene. E. coli strain 573 carried a…”
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Emergence of high-level tigecycline resistance due to the amplification of a tet(A) gene variant in clinical carbapenem-resistant Klebsiella pneumoniae by Yu, Runhao, Li, Longyu, Zou, Chenhui, Chen, Zheng, Schwarz, Stefan, Chen, Sheng, Xu, Chunyan, Yao, Hong, Du, Xiang-Dang

“…To investigate the prevalence of a tet(A) gene variant and its role in developing high-level tigecycline resistance among carbapenem-resistant Klebsiella…”
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Nickel‐Catalyzed Enantioselective Carbonyl Addition of Aryl Chlorides and Bromides to Aldehydes by Jiang, Mingjie, Yu, Limei, Zou, Chenhui, Yuan, Hao, Xu, Minghui, Chen, Bin, Hu, Ping, Wang, Bi‐Qin, Cao, Peng

“…The Ni‐catalyzed enantioselective addition reaction of aryl halides to aldehydes was studied with cyanobis(oxazoline) as chiral ligands and Mn as reductant…”
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poxtA amplification and mutations in 23S rRNA confer enhanced linezolid resistance in Enterococcus faecalis by Shan, Xinxin, Li, Chenglong, Zhang, Likuan, Zou, Chenhui, Yu, Runhao, Schwarz, Stefan, Shang, Yanhong, Li, Dexi, Brenciani, Andrea, Du, Xiang-Dang

“…This study aimed to explore the evolutionary patterns and resistance mechanisms of an Enterococcus faecalis strain harbouring poxtA under linezolid exposure. A…”
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Characterization of a Bioengineered AAV3B Capsid Variant with Enhanced Hepatocyte Tropism and Immune Evasion by Rana, Jyoti, Marsic, Damien, Zou, Chenhui, Muñoz-Melero, Maite, Li, Xin, Kondratov, Oleksandr, Li, Ning, de Jong, Ype P, Zolotukhin, Sergei, Biswas, Moanaro

“…Capsid engineering of adeno-associated virus (AAV) can surmount current limitations to gene therapy such as broad tissue tropism, low transduction efficiency,…”
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Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma by Kapelanski-Lamoureux, Audrey, Chen, Zhouji, Gao, Zu-Hua, Deng, Ruishu, Lazaris, Anthoula, Lebeaupin, Cynthia, Giles, Lisa, Malhotra, Jyoti, Yong, Jing, Zou, Chenhui, de Jong, Ype P., Metrakos, Peter, Herzog, Roland W., Kaufman, Randal J.

“…Hemophilia A gene therapy targets hepatocytes to express B domain deleted (BDD) clotting factor VIII (FVIII) to permit viral encapsidation. Since BDD is prone…”
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Long-term 3D cell culture models for hepatitis B virus studies by Jones, Christopher E., Dangas, Georgios, Norris, Adriana C., Koenig, Madeleine, Li, Dar-Yin, Shue, Taylor M., Athanasiadis, Antonis, Barbosa, Luana, Zhou, Yichen, Levenson, Kenneth C., Zou, Chenhui, de Jong, Ype P., Michailidis, Eleftherios

“…Primary human hepatocyte (PHH) models have limited longevity and require high inoculum for HBV infection with minimal spread. We aimed to develop 3D cell…”
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A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations by Wang, Qiao, Michailidis, Eleftherios, Yu, Yingpu, Wang, Zijun, Hurley, Arlene M., Oren, Deena A., Mayer, Christian T., Gazumyan, Anna, Liu, Zhenmi, Zhou, Yunjiao, Schoofs, Till, Yao, Kai-hui, Nieke, Jan P., Wu, Jianbo, Jiang, Qingling, Zou, Chenhui, Kabbani, Mohanmmad, Quirk, Corrine, Oliveira, Thiago, Chhosphel, Kalsang, Zhang, Qianqian, Schneider, William M., Jahan, Cyprien, Ying, Tianlei, Horowitz, Jill, Caskey, Marina, Jankovic, Mila, Robbiani, Davide F., Wen, Yumei, de Jong, Ype P., Rice, Charles M., Nussenzweig, Michel C.

“…Although there is no effective cure for chronic hepatitis B virus (HBV) infection, antibodies are protective and correlate with recovery from infection. To…”
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Protein interactions of SOC1 with SVP are regulated by a few crucial amino acids in flowering pathways of Brassica juncea by Li, Chaochuang, Gu, Huiying, Jiang, Wei, Zou, Chenhui, Wei, Dayong, Wang, Zhimin, Tang, Qinglin

“…SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 ( SOC1 ) is a vital flowering signal integrator to promote flowering, which is inhibited by a MADS-box transcription…”
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Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice by Kabbani, Mohammad, Michailidis, Eleftherios, Steensels, Sandra, Fulmer, Clifton G., Luna, Joseph M., Le Pen, Jérémie, Tardelli, Matteo, Razooky, Brandon, Ricardo-Lax, Inna, Zou, Chenhui, Zeck, Briana, Stenzel, Ansgar F., Quirk, Corrine, Foquet, Lander, Ashbrook, Alison W., Schneider, William M., Belkaya, Serkan, Lalazar, Gadi, Liang, Yupu, Pittman, Meredith, Devisscher, Lindsey, Suemizu, Hiroshi, Theise, Neil D., Chiriboga, Luis, Cohen, David E., Copenhaver, Robert, Grompe, Markus, Meuleman, Philip, Ersoy, Baran A., Rice, Charles M., de Jong, Ype P.

“…Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most…”
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