Search Results - "Zotchev, S B"

Polyene antibiotic biosynthesis gene clusters by APARICIO, J. F, CAFFREY, P, GIL, J. A, ZOTCHEV, S. B

“…Over the past 15 years the biosynthetic gene clusters for numerous bioactive polyketides have been intensively studied and recently this work has been extended…”
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Biosynthesis of deoxyaminosugars in antibiotic-producing bacteria by NEDAL, A, ZOTCHEV, S. B

“…Deoxyaminosugars comprise an important class of deoxysugars synthesized by a variety of different microorganisms; they can be structural components of…”
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Polyene macrolide antibiotics and their applications in human therapy by Zotchev, Sergey B

“…Fungal infections represent a serious problem for patients with immune systems compromized either by HIV infection, or administration of immunosuppressive…”
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p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core by Zotchev, S B, Protopopova, M, Selivanova, G

“…In addition to binding DNA in a sequence-specific manner, the p53 tumour suppressor protein can interact with damaged DNA. In order to understand which…”
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Identification of a methyl-specific restriction system mediated by a conjugative element from Streptomyces bambergiensis by Zotchev, S B, Schrempf, H, Hutchinson, C R

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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In Vivo Analysis of the Regulatory Genes in the Nystatin Biosynthetic Gene Cluster of Streptomyces noursei ATCC 11455 Reveals Their Differential Control Over Antibiotic Biosynthesis by SEKUROVA, Olga N, BRAUTASET, Trygve, SLETTA, Havard, BORGOS, Sven E. F, JAKOBSEN, Øyvind M, ELLINGSEN, Trond E, STRØM, Arne R, VALLA, Svein, ZOTCHEV, Sergey B

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Probing the Structure−Function Relationship of Polyene Macrolides:  Engineered Biosynthesis of Soluble Nystatin Analogues by Borgos, Sven E. F., Tsan, Pascale, Sletta, Håvard, Ellingsen, Trond E., Lancelin, Jean-Marc, Zotchev, Sergey B.

“…Although polyene macrolides are efficient antifungal agents with fungicidal mode of action, their use in medical practice is problematic due to their low…”
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Rational Design of Macrolides by Virtual Screening of Combinatorial Libraries Generated through in Silico Manipulation of Polyketide Synthases by Zotchev, Sergey B, Stepanchikova, Alla V, Sergeyko, Anastasia P, Sobolev, Boris N, Filimonov, Dmitrii A, Poroikov, Vladimir V

“…Bacterial secondary metabolites display diverse biological activities, thus having potential as pharmacological agents. Although most of these compounds are…”
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Characterization of a linear extrachromosomal DNA element (pBL1) isolated after interspecific mating between Streptomyces bambergiensis and S. lividans by Zotchev, S B, Soldatova, L I, Orekhov, A V, Schrempf, H

“…Streptomyces bambergiensis S712 harbours a giant linear plasmid PSB1 of 640 kb. After mating with the plasmidless S. lividans strain TK64, conjugants carrying…”
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Site-specific Mutagenesis and Domain Substitutions in the Loading Module of the Nystatin Polyketide Synthase, and Their Effects on Nystatin Biosynthesis in Streptomyces noursei by Brautaset, Trygve, Borgos, Sven E.F., Sletta, Håvard, Ellingsen, Trond E., Zotchev, Sergey B.

“…The loading module for the nystatin polyketide synthase (PKS) in Streptomyces noursei is represented by the NysA protein composed of a ketosynthase (KSS),…”
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The linear Streptomyces plasmid pBL1: analyses of transfer functions by Zotchev, S B, Schrempf, H

“…pBL1 is a conjugative linear extrachromosomal element of 43 kb previously isolated after interspecific mating between Streptomyces bambergiensis and S…”
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Computer-aided design of polyketides with the required properties by Sergeyko, A. P., Stepanchikova, A. V., Sobolev, B. N., Zotchev, S. B., Lagunin, A. A., Filimonov, D. A., Poroikov, V. V.

“…An approach to rational design of new polyketides with the required spectrum of biological activity has been proposed. We have developed the BioGenPharm…”
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Micropropagation and Cryoconservation of the Endangered Plant Species Artemisia laciniata (Asteraceae) by Kodym, A, Senula, A, Temsch, E M, Hood-Nowotny, R, Schumacher, F, Sekurova, O N, Zotchev, S B, Kiehn, M

“…BACKGROUND: Artemisia laciniata, mainly distributed in Siberia and Central Asia, is classified as critically endangered in Europe. This study developed a…”
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Cloning and heterologous expression of the genes encoding nonspecific electron transport components for a cytochrome P450 system of Saccharopolyspora erythraea involved in erythromycin production by Zotchev, Sergey B., Hutchinson, C.Richard

“…The forA gene encoding a protein that can function as a NADH: ferredoxin oxidoreductase (For) has been cloned from Saccharopolyspora erythraea, the…”
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Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway by Hakvåg, Sigrid, Fjaervik, Espen, Josefsen, Kjell D, Ian, Elena, Ellingsen, Trond E, Zotchev, Sergey B

“…The water surface microlayer is still poorly explored, although it has been shown to contain a high density of metabolically active bacteria, often called…”
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Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway by Brautaset, Trygve, Sekurova, Olga N, Sletta, Håvard, Ellingsen, Trond E, Strøm, Arne R, Valla, Svein, Zotchev, Sergey B

“…Background: The polyene macrolide antibiotic nystatin produced by Streptomyces noursei ATCC 11455 is an important antifungal agent. The nystatin molecule…”
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An unexpected role for the putative 4′-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in Streptomyces noursei ATCC 11455 by Volokhan, Olga, Sletta, Håvard, Sekurova, Olga N., Ellingsen, Trond E., Zotchev, Sergey B.

“…The nysF gene encoding a putative 4′-phosphopantetheinyl transferase (PPTase) is located at the 5′ border of the nystatin biosynthesis gene cluster in…”
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Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei by FJAERVIK, Espen, ZOTCHEV, Sergey B

“…The polyene macrolide antibiotic nystatin, produced commercially by the bacterium Streptomyces noursei, is an important antifungal agent used in human therapy…”
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Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin by Guerrero-Garzón, Jaime Felipe, Madland, Eva, Zehl, Martin, Singh, Madhurendra, Rezaei, Shiva, Aachmann, Finn L., Courtade, Gaston, Urban, Ernst, Rückert, Christian, Busche, Tobias, Kalinowski, Jörn, Cao, Yan-Ru, Jiang, Yi, Jiang, Cheng-lin, Selivanova, Galina, Zotchev, Sergey B.

“…Heterologous expression of a biosynthesis gene cluster from Amycolatopsis sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1…”
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Hexaene Derivatives of Nystatin Produced as a Result of an Induced Rearrangement within the nysC Polyketide Synthase Gene in S. noursei ATCC 11455 by Brautaset, Trygve, Bruheim, Per, Sletta, Håvard, Hagen, Lars, Ellingsen, Trond E, Strøm, Arne R, Valla, Svein, Zotchev, Sergey B

“…Genetic manipulation of the polyketide synthase (PKS) gene nysC involved in the biosynthesis of the tetraene antifungal antibiotic nystatin yielded a…”
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