Search Results - "Zorzi, Giovanni K."

Box Behnken design of siRNA-loaded liposomes for the treatment of a murine model of ocular keratitis caused by Acanthamoeba by Zorzi, Giovanni K., Schuh, Roselena S., Maschio, Vinicius J., Brazil, Nathalya T., Rott, Marilise B., Teixeira, Helder F.

“…[Display omitted] •A liposomal vector was proposed and optimized by Box Behnken design tool.•siRNA was efficiently complexed with liposome at +5/−1 charge…”
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Nanoparticles based on naturally-occurring biopolymers as versatile delivery platforms for delicate bioactive molecules: An application for ocular gene silencing by Parraga, Jenny E., Zorzi, Giovanni K., Diebold, Yolanda, Seijo, Begoña, Sanchez, Alejandro

“…[Display omitted] Nanoparticles based on naturally-occurring biopolymers, most of them endogenous macromolecules, were designed as a versatile generation of…”
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siRNA‐loaded liposomes: Inhibition of encystment of Acanthamoeba and toxicity on the eye surface by Faber, Kathrin, Zorzi, Giovanni K., Brazil, Nathalya T., Rott, Marilise B., Teixeira, Helder F.

“…Current treatments for Acanthamoeba keratitis are unspecific. Because of the presence of the resilient cyst form of the parasite, the infection is persistent…”
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Quercetin and 3‐O‐methylquercetin in vitro skin layers permeation/retention from hydrogels: why only a methoxy group difference determines different behaviors? by Schwingel, Liege C., Bianchi, Sara E., Zorzi, Giovanni K., Gonçalves, Paulo, Teixeira, Helder F., Bassani, Valquiria L.

“…Objectives The present study was designed to verify if quercetin (QCT), a flavonoid with antioxidant and antiviral activity, and 3‐O‐methylquercetin (3OMQ), a…”
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Comparison of different cationized proteins as biomaterials for nanoparticle-based ocular gene delivery by Zorzi, Giovanni K., Párraga, Jenny E., Seijo, Begoña, Sanchez, Alejandro

“…[Display omitted] •Cationized proteins were used for nanoparticulate ocular gene delivery.•Albumin, gelatin and atelocollagen were cationized with spermine or…”
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Structural analysis of nanosystems: Solid Sorbitan esters Nanoparticles (SSN) as a case study by Pensado, Andrea, Martín-Pastor, Manuel, Zorzi, Giovanni K., Carvalho, Edison S., Sanchez, Alejandro

“…[Display omitted] Innovative approaches in nanotechnology can provide drug delivery systems with a high potential in different fields. To avoid trial and error…”
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A chemically-induced acute model of maple syrup urine disease in rats for neurochemical studies by Bridi, Raquel, Fontella, Fernanda U., Pulrolnik, Vânia, Braun, César A., Zorzi, Giovanni K., Coelho, Daniella, Wajner, Moacir, Vargas, Carmen Regla, Dutra-Filho, Carlos Severo

“…We report a chemically-induced model of maple syrup urine disease (MSUD) in 10- and 30-day-old rats produced by subcutaneous administration of a branched-chain…”
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Evaluation of the mechanisms involved in leucine-induced oxidative damage in cerebral cortex of young rats by Bridi, Raquel, Latini, Alexandra, Braum, Cesar A, Zorzi, Giovanni K, Moacir, Wajner, Lissi, Eduardo, Dutra-Filho, Carlos Severo

“…Maple syrup urine disease (MSUD) is a metabolic disorder caused by the deficiency of the activity of the mitochondrial enzyme complex branched-chain L-2-keto…”
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α-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats by BRIDI, Raquel, BRAUN, César A, ZORZI, Giovanni K, WANNMACHER, Clovis M. D, WAJNER, Moacir, LISSI, Eduardo G, DUTRA-FILHO, Carlos Severo

“…Maple syrup urine disease (MSUD) is an inherited neurometabolic disorder caused by deficiency of branched-chain alpha-keto acid dehydrogenase complex activity…”
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5-Oxoproline reduces non-enzymatic antioxidant defenses in vitro in rat brain by Pederzolli, Carolina D, Sgaravatti, Angela M, Braum, César A, Prestes, Cristina C, Zorzi, Giovanni K, Sgarbi, Mirian B, Wyse, Angela T S, Wannmacher, Clóvis M D, Wajner, Moacir, Dutra-Filho, Carlos S

“…5-Oxoproline (pyroglutamic acid) accumulates in glutathione synthetase deficiency, an inborn metabolic defect of the gamma-glutamyl cycle. This disorder is…”
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Citrulline and ammonia accumulating in citrullinemia reduces antioxidant capacity of rat brain in vitro by PRESTES, Cristina C, SGARAVATTI, Angela M, PEDERZOLLI, Carolina D, SGARBI, Mirian B, ZORZI, Giovanni K, WANNMACHER, Clovis M. D, WAJNER, Moacir, WYSE, Angela T. S, SEVERO DUTRA-FILHO, Carlos

“…Citrullinemia is an inborn error of the urea cycle caused by deficient argininosuccinate synthetase, which leads to accumulation of L-citrulline and ammonia in…”
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si RNA ‐loaded liposomes: Inhibition of encystment of Acanthamoeba and toxicity on the eye surface by Faber, Kathrin, Zorzi, Giovanni K., Brazil, Nathalya T., Rott, Marilise B., Teixeira, Helder F.

“…Current treatments for Acanthamoeba keratitis are unspecific. Because of the presence of the resilient cyst form of the parasite, the infection is persistent…”
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Incorporation of Achyrocline satureioides (Lam.) DC extracts into topical nanoemulsions obtained by means of spontaneous emulsification procedure by Bidone, Juliana, Zorzi, Giovanni K., Carvalho, Edison L.S., Simões, Cláudia M.O., Koester, Letícia S., Bassani, Valquiria L., Teixeira, Helder F.

“…•Achyrocline satureioides liquid or dried extracts were incorporated in nanoemulsions.•Formulations can be obtained by spontaneous emulsification procedure in…”
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[alpha]-Keto Acids Accumulating in Maple Syrup Urine Disease Stimulate Lipid Peroxidation and Reduce Antioxidant Defences in Cerebral Cortex From Young Rats by Bridi, Raquel, Braun, César A, Zorzi, Giovanni K, Wannmacher, Clóvis M D, Wajner, Moacir, Lissi, Eduardo G, Dutra-Filho, Carlos Severo

“…Maple syrup urine disease (MSUD) is an inherited neurometabolic disorder caused by deficiency of branched-chain α-keto acid dehydrogenase complex activity…”
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BIOMATERIAIS PARA FORMULAÇÕES DE BASE NANOTECNOLÓGICA VISANDO TERAPIA GENÉTICA OCULAR by Giovanni K. Zorzi, Roselena S. Schuh, Angela M. de Campos, Edison L. S. Carvalho, Marilise B. Rott, Helder F. Teixeira

“…Gene therapy is a promising tool for the treatment of ocular diseases. Nevertheless, there are some import limitations, especially related to the ocular route…”
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