Jatrophane diterpenoids from Euphorbia mongolica as modulators of the multidrug resistance of L5128 mouse lymphoma cells

The dried aerial parts of Euphorbia mongolica afforded three new acylated polyhydroxy diterpenoids based on the jatrophane framework. The structures were established by means of a combination of 1D and 2D NMR techniques and mass spectrometry as (2S,3S,4R,5R,7S,8R,13S,15R)-5alpha,7beta,8alpha-triacet...

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Bibliographic Details
Published in:	Journal of natural products (Washington, D.C.) Vol. 66; no. 7; pp. 976 - 979
Main Authors:	Hohmann, J, Redei, D, Forgo, P, Molnar, J, Dombi, G, Zorig, T
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-07-2003 Glendale, AZ American Society of Pharmacognosy
Subjects:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology antineoplastic drug resistance Biological and medical sciences carbon cell lines chemical structure Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoids dose response Drug Resistance, Multiple - drug effects Drug Screening Assays, Antitumor esters Euphorbia Euphorbia - chemistry Euphorbia mongolica General pharmacology isolation jatrophane diterpenoids Lymphoma Medical sciences medicinal plants methine Mice Molecular Structure Mongolia multiple drug resistance Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plants, Medicinal - chemistry protons spectral analysis stereochemistry Stereoisomerism Tumor Cells, Cultured - drug effects Mongolia Asia Ketol P Glycoprotein Medicinal plant Folk medicine Dicotyledones Modulation Multiple resistance Angiospermae Bicyclic compound Euphorbiaceae Inhibition Polyol Acylate Tumor cell Carrier protein Transmembrane protein Terpenoid Pharmacognosy Rodentia In vitro Lymphoma Biological activity Euphorbia Vertebrata Mammalia Cell line Mouse Animal Plant origin Diterpene Isolation Above ground plant part Reversibility Spermatophyta Chemosensitizing agent Structural analysis
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Summary:	The dried aerial parts of Euphorbia mongolica afforded three new acylated polyhydroxy diterpenoids based on the jatrophane framework. The structures were established by means of a combination of 1D and 2D NMR techniques and mass spectrometry as (2S,3S,4R,5R,7S,8R,13S,15R)-5alpha,7beta,8alpha-triacetoxy-3beta-benzoyloxy-15beta-hydroxyjatropha-6(17),11E-diene-9,14-dione (1), (2S,3S,4R,5R,7S,8S,9S13S,15R)-5alpha,7beta,8alpha,9alpha,15beta-pentaacetoxy-3beta-benzoyloxyjatropha-6(17),11E-dien-14-one (2), and (2S,3S,4R,5R,7S,8S,9S13S,15R)-3beta,7beta,8alpha,9alpha,15beta-pentaacetoxy-5alpha-benzoyloxyjatropha-6(17),11E-dien-14-one (3). When the isolates were assayed for multidrug resistance-reversing activity in a rhodamine 123 exclusion test using L5178 mouse lymphoma cells, all compounds demonstrated a concentration-dependent effect in inhibiting the efflux pump activity of these tumor cells in the range 11.2-112 microM.
Bibliography:	ark:/67375/TPS-VR7K9Q70-J istex:B887FDAA89FCD4B75A9E80F8E9C522708A2F63A9 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np030036f