Geranium macrorrhizum L. (Geraniaceae) Essential Oil: A Potent Agent Against Bacillus subtilis

The volatile hydrodistilled compounds from aerial parts and rhizomes of the ethnopharmacologically highly valued plant species Geranium macrorrhizum L. were screened for their antimicrobial activity in disc‐diffusion and microdilution assays. The assays pointed out to a very high and selective activ...

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Bibliographic Details
Published in:	Chemistry & biodiversity Vol. 7; no. 11; pp. 2783 - 2800
Main Authors:	Radulovic, Niko S, Dekic, Milan S, Stojanovic-Radic, Zorica Z, Zoranic, Suad K
Format:	Journal Article
Language:	English
Published:	Zürich WILEY-VCH Verlag 01-11-2010 WILEY‐VCH Verlag
Subjects:	Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antimicrobial activity Azulenes - chemistry Azulenes - isolation & purification Azulenes - pharmacology Bacillus subtilis Bacillus subtilis - drug effects Essential oils Gas Chromatography-Mass Spectrometry Geraniaceae Geranium Geranium - chemistry Geranium macrorrhizum Germacrone Microbial Sensitivity Tests Oils, Volatile - chemistry Oils, Volatile - isolation & purification Oils, Volatile - pharmacology Plant Components, Aerial - chemistry Rhizome - chemistry Sesquiterpenes, Germacrane - chemistry Sesquiterpenes, Germacrane - isolation & purification Sesquiterpenes, Germacrane - pharmacology Sesquiterpenes, Guaiane - chemistry Sesquiterpenes, Guaiane - isolation & purification Sesquiterpenes, Guaiane - pharmacology Sesquiterpenoids δ-Guaiene
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Summary:	The volatile hydrodistilled compounds from aerial parts and rhizomes of the ethnopharmacologically highly valued plant species Geranium macrorrhizum L. were screened for their antimicrobial activity in disc‐diffusion and microdilution assays. The assays pointed out to a very high and selective activity of the oils against Bacillus subtilis with minimum inhibitory concentrations (MIC) of 0.4–1.0 μg/ml. This prompted us to perform detailed compositional analyses of the oils. GC and GC/MS analyses allowed the identification of 283 constituents. The oils consisted mainly of sesquiterpenoids, the main ones being germacrone (49.7% in the oil from aerial parts) and δ‐guaiene (49.2% in rhizome oil). Significant qualitative and quantitative compositional differences in the oils from the two plant parts were observed. Further antimicrobial testing enabled us to determine that germacrone, the major constituent of the oil from aerial parts, was not the sole agent responsible for the observed activity.
Bibliography:	ArticleID:CBDV201000100 istex:F3837B9C9C5EA459DC79A1D70A659B39ABE07AA5 ark:/67375/WNG-ZFR2MLH8-6 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1612-1872 1612-1880 1612-1880
DOI:	10.1002/cbdv.201000100