Search Results - "Zoppe, Monica"
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Inferring 3D chromatin structure using a multiscale approach based on quaternions
Published in BMC bioinformatics (29-07-2015)“…The knowledge of the spatial organisation of the chromatin fibre in cell nuclei helps researchers to understand the nuclear machinery that regulates DNA…”
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ChromStruct 4: A Python Code to Estimate the Chromatin Structure from Hi-C Data
Published in IEEE/ACM transactions on computational biology and bioinformatics (01-11-2019)“…A method and a stand-alone Python code to estimate the 3D chromatin structure from chromosome conformation capture data are presented. The method is based on a…”
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Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses
Published in Viruses (27-05-2022)“…Pyridobenzothiazolone derivatives are a promising class of broad-spectrum antivirals. However, the mode of action of these compounds remains poorly understood…”
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Towards a perceptive understanding of size in cellular biology
Published in Nature methods (01-07-2017)“…This piece tackles the question of how to make biological scale more intuitive to human beings, bringing to bear the author's background in scientific…”
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Colors in the representation of biological structures
Published in Journal of integrative bioinformatics (04-07-2022)“…Among the many properties of proteins, sugars, nucleic acids, membranes and other cellular components, color is not present. At the same time, we humans have a…”
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Potentiation of gene targeting in human cells by expression of Saccharomyces cerevisiae Rad52
Published in Nucleic acids research (01-01-2005)“…When exogenous DNA is stably introduced in mammalian cells, it is typically integrated in random positions, and only a minor fraction enters a pathway of…”
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Ribozyme-mediated inhibition of survivin expression increases spontaneous and drug-induced apoptosis and decreases the tumorigenic potential of human prostate cancer cells
Published in Oncogene (15-01-2004)“…Survivin is a member of the inhibitor of apoptosis protein (IAP) family, which has been implicated in inhibition of apoptosis and control of mitotic…”
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A Factor IX-Deficient Mouse Model for Hemophilia B Gene Therapy
Published in Proceedings of the National Academy of Sciences - PNAS (14-10-1997)“…We have generated a mouse where the clotting factor IX (FIX) gene has been disrupted by homologous recombination. The FIX nullizygous (-/-) mouse was devoid of…”
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Computational design, fabrication and evaluation of rubber protein models
Published in Computers & graphics (01-08-2021)“…•We introduce a complete workflow for the fabrication of soft 3D models of complex proteins.•The workflow enables the fabrication of tangible models of…”
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The human cytomegalovirus UL45 gene product is a late, virion-associated protein and influences virus growth at low multiplicities of infection
Published in Journal of general virology (01-12-2003)“…1 Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, I-27100 Pavia, Italy 2 Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy 3…”
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Generation of Targeted Retroviral Vectors by Using Single-Chain Variable Fragment: An Approach to in vivo Gene Delivery
Published in Proceedings of the National Academy of Sciences - PNAS (01-08-1995)“…We report the generation of a retroviral vector that infects human cells specifically through recognition of the low density lipoprotein receptor. The…”
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Integration of Multiple Resolution Data in 3D Chromatin Reconstruction Using ChromStruct
Published in Biology (Basel, Switzerland) (16-04-2021)“…The three-dimensional structure of chromatin in the cellular nucleus carries important information that is connected to physiological and pathological…”
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Intuitive representation of surface properties of biomolecules using BioBlender
Published in BMC bioinformatics (28-03-2012)“…In living cells, proteins are in continuous motion and interaction with the surrounding medium and/or other proteins and ligands. These interactions are…”
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Estimation of the Spatial Chromatin Structure Based on a Multiresolution Bead-Chain Model
Published in IEEE/ACM transactions on computational biology and bioinformatics (01-03-2019)“…We present a method to infer 3D chromatin configurations from Chromosome Conformation Capture data. Quite a few methods have been proposed to estimate the…”
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Myocardial contractility in the stress echo lab: from pathophysiological toy to clinical tool
Published in Cardiovascular ultrasound (18-11-2013)“…Up-regulation of Ca2+ entry through Ca2+ channels by high rates of beating is involved in the frequency-dependent regulation of contractility: this process is…”
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Transcellular transfer of active HSV-1 thymidine kinase mediated by an 11-amino-acid peptide from HIV-1 Tat
Published in Cancer Gene Therapy (01-01-2003)“…Suicide gene therapy using herpes simplex virus type-1 (HSV-1) thymidine kinase (TK) is a widely exploited approach for gene therapy of cancer and other…”
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High-level biocontainment laboratories: risks and necessity for society [version 1; peer review: 1 approved, 1 not approved]
Published in F1000 research (2022)“…Advancements in the biological sciences have made it possible to manipulate life forms in unprecedented ways. Recognizing the possible dangers connected with…”
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Mannose analog 1-deoxymannojirimycin inhibits the Golgi-mediated processing of bean storage glycoproteins
Published in Plant physiology (Bethesda) (01-04-1989)“…The asparagine-linked oligosaccharide chains of glycoproteins can be processed to form a wide variety of structures. The Golgi complex is the main compartment…”
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Synthesis of lectin-like protein in developing cotyledons of normal and phytohemagglutinin-deficient Phaseolus vulgaris
Published in Plant physiology (Bethesda) (01-07-1989)“…The genome of the common bean Phaseolus vulgaris contains a small gene family that encodes lectin and lectin-like proteins (phytohemagglutinin, arcelin, and…”
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