Search Results - "Zopf, Steffen"

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis by Buch, Stephan, Stickel, Felix, Trépo, Eric, Way, Michael, Herrmann, Alexander, Nischalke, Hans Dieter, Brosch, Mario, Rosendahl, Jonas, Berg, Thomas, Ridinger, Monika, Rietschel, Marcella, McQuillin, Andrew, Frank, Josef, Kiefer, Falk, Schreiber, Stefan, Lieb, Wolfgang, Soyka, Michael, Semmo, Nasser, Aigner, Elmar, Datz, Christian, Schmelz, Renate, Brückner, Stefan, Zeissig, Sebastian, Stephan, Anna-Magdalena, Wodarz, Norbert, Devière, Jacques, Clumeck, Nicolas, Sarrazin, Christoph, Lammert, Frank, Gustot, Thierry, Deltenre, Pierre, Völzke, Henry, Lerch, Markus M, Mayerle, Julia, Eyer, Florian, Schafmayer, Clemens, Cichon, Sven, Nöthen, Markus M, Nothnagel, Michael, Ellinghaus, David, Huse, Klaus, Franke, Andre, Zopf, Steffen, Hellerbrand, Claus, Moreno, Christophe, Franchimont, Denis, Morgan, Marsha Y, Hampe, Jochen

“…Felix Stickel and colleagues report the results of a genome-wide association study of alcohol-related cirrhosis. They confirm PNPLA3 as a susceptibility locus…”
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Advances in hepatitis C therapy: What is the current state - what come's next? by Zopf, Steffen, Kremer, Andreas E, Neurath, Markus F, Siebler, Juergen

“…Chronic hepatitis C virus (HCV) infection affects 80-160 million people worldwide and is one of the leading causes of chronic liver disease. It is only a few…”
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I-scan optical enhancement for the in vivo prediction of diminutive colorectal polyp histology: Results from a prospective three-phased multicentre trial by Klenske, Entcho, Zopf, Steffen, Neufert, Clemens, Nägel, Andreas, Siebler, Jürgen, Gschossmann, Jürgen, Mühldorfer, Steffen, Pfeifer, Lukas, Fischer, Sarah, Vitali, Francesco, Iacucci, Marietta, Ghosh, Subrata, Rath, Michelle G, Klare, Peter, Tontini, Gian E, Neurath, Markus F, Rath, Timo

“…Dye-less chromoendoscopy is an emerging technology for colorectal polyp characterization. Herein, we investigated whether the newly introduced I-scan optical…”
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Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines by Zopf, Steffen, Ocker, Matthias, Neureiter, Daniel, Alinger, Beate, Gahr, Susanne, Neurath, Markus F, Di Fazio, Pietro

“…Hepatocellular carcinoma (HCC) still represents an unmet medical need. Epigenetic inactivation of tumor suppressor genes like RASSF1A or APC by overexpression…”
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Combined inhibitors of angiogenesis and histone deacetylase：Efficacy in rat hepatoma by Ganslmayer, Marion, Zimmermann, Annette, Zopf, Steffen, Herold, Christoph

“…AIM：To evaluate the antitumoral effect of combined inhibitors of angiogenesis and histone deacetylases in an experimental rat hepatoma model.METHODS：MH7777A…”
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Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models by Neureiter, Daniel, Zopf, Steffen, Leu, Thorsten, Dietze, Otto, Hauser-Kronberger, Cornelia, Hahn, Eckhart G., Herold, Christoph, Ocker, Matthias

“…Objective. Pancreatic cancer continues to be an urgent clinical problem. We used the novel DNA methyltransferase inhibitor Zebularine and the histone…”
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A large cohort of patients with hepatocellular carcinoma in a single European centre: aetiology and prognosis now and in a historical cohort by Ganslmayer, Marion, Hagel, Alexander, Dauth, Wolfgang, Zopf, Steffen, Strobel, Deike, Müller, Volker, Uder, Michael, Neurath, Markus F, Siebler, Jürgen

“…The incidence of hepatocellular carcinoma is rising. However, this is occurring not only in developing nations, but in industrial countries as well…”
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Combination of the deacetylase inhibitor panobinostat and the multi-kinase inhibitor sorafenib for the treatment of metastatic hepatocellular carcinoma - review of the underlying molecular mechanisms and first case report by Gahr, Susanne, Wissniowski, Till, Zopf, Steffen, Strobel, Deike, Pustowka, Anette, Ocker, Matthias

“…Advanced hepatocellular carcinoma still represents an unmet medical need that has only a limited overall survival despite the introduction of the multi-kinase…”
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The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells by OCKER, Matthias, ALAJATI, Abdullah, GANSLMAYER, Marion, ZOPF, Steffen, LUDERS, Mike, NEUREITER, Daniel, HAHN, Eckhart G, SCHUPPAN, Detlef, HEROLD, Christoph

“…Treatment for advanced stages of hepatocellular carcinoma (HCC) remains unsatisfactory. While 5-fluorouracil (5-FU) and irinotecan are first-line treatment…”
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Improvement of quantitative testing of liver function in patients with chronic hepatitis C after installment of antiviral therapy by Ocker, Matthias, Ganslmayer, Marion, Zopf, Steffen, Gahr, Susanne, Janson, Christopher, Hahn, Eckhart-G, Herold, Christoph

“…To investigate if and to what extent antiviral therapy influenced a broad panel of quantitative testing of liver function (QTLF). Fifty patients with chronic…”
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Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis by Mchedlidze, Tamar, Waldner, Maximilian, Zopf, Steffen, Walker, Jennifer, Rankin, Andrew L., Schuchmann, Marcus, Voehringer, David, McKenzie, Andrew N.J., Neurath, Markus F., Pflanz, Stefan, Wirtz, Stefan

“…Liver fibrosis is a consequence of chronic liver diseases and thus a major cause of mortality and morbidity. Clinical evidence and animal studies suggest that…”
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Comparison of Hemospray ® and Endoclot ™ for the treatment of gastrointestinal bleeding by Vitali, Francesco, Naegel, Andreas, Atreya, Raja, Zopf, Steffen, Neufert, Clemens, Siebler, Juergen, Neurath, Markus F, Rath, Timo

“…Gastrointestinal (GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders (HP) represent "touch-free" agents. To analyze…”
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Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis by Stickel, Felix, Buch, Stephan, Nischalke, Hans Dieter, Weiss, Karl Heinz, Gotthardt, Daniel, Fischer, Janett, Rosendahl, Jonas, Marot, Astrid, Elamly, Mona, Casper, Markus, Lammert, Frank, McQuillin, Andrew, Zopf, Steffen, Spengler, Ulrich, Marhenke, Silke, Kirstein, Martha M, Vogel, Arndt, Eyer, Florian, von Felden, Johann, Wege, Henning, Buch, Thorsten, Schafmayer, Clemens, Braun, Felix, Deltenre, Pierre, Berg, Thomas, Morgan, Marsha Y, Hampe, Jochen

“…Variants in patatin-like phospholipase domain-containing 3 (PNPLA3; rs738409), transmembrane 6 superfamily member 2 (TM6SF2; rs58542926), and membrane bound…”
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Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers by Stickel, Felix, Lutz, Philipp, Buch, Stephan, Nischalke, Hans Dieter, Silva, Ines, Rausch, Vanessa, Fischer, Janett, Weiss, Karl Heinz, Gotthardt, Daniel, Rosendahl, Jonas, Marot, Astrid, Elamly, Mona, Krawczyk, Marcin, Casper, Markus, Lammert, Frank, Buckley, Thomas W. M., McQuillin, Andrew, Spengler, Ulrich, Eyer, Florian, Vogel, Arndt, Marhenke, Silke, Felden, Johann, Wege, Henning, Sharma, Rohini, Atkinson, Stephen, Franke, Andre, Nehring, Sophie, Moser, Vincent, Schafmayer, Clemens, Spahr, Laurent, Lackner, Carolin, Stauber, Rudolf E., Canbay, Ali, Link, Alexander, Valenti, Luca, Grove, Jane I., Aithal, Guruprasad P., Marquardt, Jens U., Fateen, Waleed, Zopf, Steffen, Dufour, Jean‐Francois, Trebicka, Jonel, Datz, Christian, Deltenre, Pierre, Mueller, Sebastian, Berg, Thomas, Hampe, Jochen, Morgan, Marsha Y.

“…Background and Aims Carriage of rs738409:G in patatin‐like phospholipase domain containing 3 (PNPLA3) is associated with an increased risk for developing…”
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Retrograde inspection vs standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial by Rath, Timo, Pfeifer, Lukas, Neufert, Clemens, Kremer, Andreas, Leppkes, Moritz, Hoffman, Arthur, Neurath, Markus F, Zopf, Steffen

“…The adenoma detection rate (ADR) is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during…”
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Effects of liver cirrhosis and patient condition on clinical outcomes in intrahepatic cholangiocarcinoma: a retrospective analysis of 156 cases in a single center by Jesper, Daniel, Heyn, Sabrina G, Schellhaas, Barbara, Pfeifer, Lukas, Goertz, Ruediger S, Zopf, Steffen, Neurath, Markus F, Strobel, Deike

“…OBJECTIVEThe incidence of intrahepatic cholangiocarcinoma (iCCA) has been increasing over the past few decades. Liver cirrhosis is an independent risk factor…”
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Improvement of clinical management and outcome in hepatocellular carcinoma nowadays compared with historical cohorts by Schellhaas, Barbara, Strobel, Deike, Stumpf, Miriam, Ganslmayer, Marion, Pfeifer, Lukas, Goertz, Ruediger S, Neurath, Markus F, Zopf, Steffen

“…OBJECTIVESTherapeutic approaches in the treatment of hepatocellular carcinoma (HCC) depend on tumour stage, liver function and patient comorbidities. The aim…”
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Acoustic radiation force impulse elastography: comparison and combination with other noninvasive tests for the diagnosis of compensated liver cirrhosis by Pfeifer, Lukas, Adler, Werner, Zopf, Steffen, Siebler, Jürgen, Wildner, Dane, Goertz, Ruediger S, Schellhaas, Barbara, Neurath, Markus F, Strobel, Deike

“…BACKGROUND AND AIMSThe aim of this study was to compare acoustic radiation force impulse (ARFI) elastography with other noninvasive tests and to develop a new…”
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Mo1699 I-SCAN OPTICAL ENHANCEMENT FOR THE IN VIVO PREDICTION OF DIMINUTIVE COLORECTAL POLYP HISTOLOGY: RESULTS FROM A PROSPECTIVE THREE-PHASED MULTICENTRE TRIAL by Klenske, Entcho, Zopf, Steffen, Neufert, Clemens, Nägel, Andreas, Siebler, Jürgen, Gschossmann, Jürgen, Mühldorfer, Steffen, Pfeifer, Lukas, Fischer, Sarah, Vitali, Francesco, Iacucci, Marietta, Ghosh, Subrata, Klare, Peter, Tontini, Gian Eugenio, Neurath, Markus, Rath, Timo

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PS-177-HSD17B13 rs72613567 TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis by Stickel, Felix, Lutz, Philipp, Buch, Stephan, Fischer, Janett, Rausch, Vanessa, Silva, Ines, Rosendahl, Jonas, Nischalke, Hans Dieter, Krawczyk, Marcin, Lammert, Frank, Casper, Markus, Zopf, Steffen, Marhenke, Silke, Vogel, Arndt, Eyer, Florian, Felden, Johann von, Gotthardt, Daniel, Weiss, Karl Heinz, Spengler, Ulrich, Mueller, Sebastian, Canbay, Ali, Baselli, Guido Alessandro, Valenti, Luca, McQuillin, Andrew, Berg, Thomas, Hampe, Jochen, Morgan, Marsha

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