Search Results - "Zonta, Nicola"

Design, synthesis and structure–activity relationship of 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[ b]furan derivatives as a novel class of inhibitors of tubulin polymerization by Romagnoli, Romeo, Baraldi, Pier Giovanni, Carrion, Maria Dora, Cara, Carlota Lopez, Cruz-Lopez, Olga, Tolomeo, Manlio, Grimaudo, Stefania, Cristina, Antonietta Di, Pipitone, Maria Rosaria, Balzarini, Jan, Zonta, Nicola, Brancale, Andrea, Hamel, Ernest

“…The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small…”
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Synthesis and Biological Evaluation of 1-Methyl-2-(3′,4′,5′-trimethoxybenzoyl)-3-aminoindoles as a New Class of Antimitotic Agents and Tubulin Inhibitors by Romagnoli, Romeo, Baraldi, Pier Giovanni, Sarkar, Taradas, Carrion, Maria Dora, Cara, Carlota Lopez, Cruz-Lopez, Olga, Preti, Delia, Tabrizi, Mojgan Aghazadeh, Tolomeo, Manlio, Grimaudo, Stefania, Di Cristina, Antonella, Zonta, Nicola, Balzarini, Jan, Brancale, Andrea, Hsieh, Hsing-Pang, Hamel, Ernest

“…The 2-(3,4,5-trimethoxybenzoyl)-2-aminoindole nucleus was used as the fundamental structure for the synthesis of compounds modified with respect to positions…”
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Advanced in silico Approaches in Antiviral Research by Zonta, Nicola, Coluccia, Antonio, Brancale, Andrea

“…Computer-aided drug design has seen constantly increasing application over the past two decades in every area of drug discovery. It can offer significant…”
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Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus by Bassetto, Marcella, De Burghgraeve, Tine, Delang, Leen, Massarotti, Alberto, Coluccia, Antonio, Zonta, Nicola, Gatti, Valerio, Colombano, Giampiero, Sorba, Giovanni, Silvestri, Romano, Tron, Gian Cesare, Neyts, Johan, Leyssen, Pieter, Brancale, Andrea

“…► A homology model for the CHIKV nsP2 protease was constructed and validated. ► A new class of inhibitors of CHIKV replication was identified by virtual…”
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Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus by McGuigan, Christopher, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Brancale, Andrea, Zonta, Nicola, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff, Hall, Andrea, Ames, Brenda, Gorovits, Elena, Ganguly, Babita, Kolykhalov, Alexander, Wang, Jin, Muhammad, Jerry, Patti, Joseph M., Henson, Geoffrey

“…Phosphoramidate ProTides of 2′-C-Me-6-MeOG are up to 500-fold more potent versus HCV than the 2′-C-MeG parent, being active at nanomolar levels. The lead has…”
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Design, synthesis, and biological evaluation of thiophene analogues of chalcones by Romagnoli, Romeo, Baraldi, Pier Giovanni, Carrion, Maria Dora, Cara, Carlota Lopez, Cruz-Lopez, Olga, Preti, Delia, Tolomeo, Manlio, Grimaudo, Stefania, Cristina, Antonella Di, Zonta, Nicola, Balzarini, Jan, Brancale, Andrea, Sarkar, Taradas, Hamel, Ernest

“…Chalcones are characterized by possessing an enone moiety between two aromatic rings. A series of chalcone-like agents, in which the double bond of the enone…”
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Synthesis and Antiviral Activity of the Carbocyclic Analogue of the Highly Potent and Selective Anti-VZV Bicyclo Furano Pyrimidines by Migliore, Marco D, Zonta, Nicola, McGuigan, Christopher, Henson, Geoffrey, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan

“…Carbocyclic nucleoside analogues are catabolically stable since they are resistant to phosphorolytic cleavage by pyrimidine nucleoside phosphorylase enzymes…”
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Accessible haptic technology for drug design applications by Zonta, Nicola, Grimstead, Ian J., Avis, Nick J., Brancale, Andrea

“…Structure-based drug design is a creative process that displays several features that make it closer to human reasoning than to machine automation. However,…”
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Virtual Reality Applications in Antiviral Drug Design by Zonta, Nicola, Brancale, Andrea

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Development and application of modelling techniques in drug design by Zonta, Nicola

“…Structure-based drug design is a creative process that displays several features that make it closer to human reasoning than to machine automation. However,…”
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