Search Results - "Zonta, Francesca"

A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis by Lupo, Francesca, Tibaldi, Elena, Matte, Alessandro, Sharma, Alok K., Brunati, Anna Maria, Alper, Seth L., Zancanaro, Carlo, Benati, Donatella, Siciliano, Angela, Bertoldi, Mariarita, Zonta, Francesca, Storch, Alexander, Walker, Ruth H., Danek, Adrian, Bader, Benedikt, Hermann, Andreas, De Franceschi, Lucia

“…Chorea-acanthocytosis is one of the hereditary neurodegenerative disorders known as the neuroacanthocytoses. Chorea-acanthocytosis is characterized by…”
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A novel class of selective CK2 inhibitors targeting its open hinge conformation by Dalle Vedove, Andrea, Zonta, Francesca, Zanforlin, Enrico, Demitri, Nicola, Ribaudo, Giovanni, Cazzanelli, Giulia, Ongaro, Alberto, Sarno, Stefania, Zagotto, Giuseppe, Battistutta, Roberto, Ruzzene, Maria, Lolli, Graziano

“…Protein kinase CK2 sustains cancer growth, especially in hematological malignancies. Its inhibitor SRPIN803, based on a…”
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Lyn sustains oncogenic signaling in chronic lymphocytic leukemia by strengthening SET-mediated inhibition of PP2A by Zonta, Francesca, Pagano, Mario Angelo, Trentin, Livio, Tibaldi, Elena, Frezzato, Federica, Trimarco, Valentina, Facco, Monica, Zagotto, Giuseppe, Pavan, Valeria, Ribaudo, Giovanni, Bordin, Luciana, Semenzato, Gianpietro, Brunati, Anna Maria

“…Aberrant protein kinase activities, and the consequent dramatic increase of Ser/Thr and -Tyr phosphorylation, promote the deregulation of the survival pathways…”
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Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells by Tibaldi, Elena, Pagano, Mario Angelo, Frezzato, Federica, Trimarco, Valentina, Facco, Monica, Zagotto, Giuseppe, Ribaudo, Giovanni, Pavan, Valeria, Bordin, Luciana, Visentin, Andrea, Zonta, Francesca, Semenzato, Gianpietro, Brunati, Anna Maria, Trentin, Livio

“…Lyn, a member of the Src family of kinases, is a key factor in the dysregulation of survival and apoptotic pathways of malignant B cells in chronic lymphocytic…”
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Cortactin, another player in the Lyn signaling pathway, is over-expressed and alternatively spliced in leukemic cells from patients with B-cell chronic lymphocytic leukemia by Gattazzo, Cristina, Martini, Veronica, Frezzato, Federica, Trimarco, Valentina, Tibaldi, Elena, Castelli, Monica, Facco, Monica, Zonta, Francesca, Brunati, Anna Maria, Zambello, Renato, Semenzato, Gianpietro, Trentin, Livio

“…Cortactin, an actin binding protein and Lyn substrate, is up-regulated in several cancers and its level is associated with increased cell migration, metastasis…”
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The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling by Tibaldi, Elena, Zonta, Francesca, Bordin, Luciana, Magrin, Elisa, Gringeri, Enrico, Cillo, Umberto, Idotta, Giuseppe, Pagano, Mario Angelo, Brunati, Anna Maria

“…The dimerization and auto-transphosphorylation of platelet-derived growth factor receptor (PDGFR) upon engagement by platelet-derived growth factor (PDGF)…”
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Contribution of the CK2 Catalytic Isoforms α and α' to the Glycolytic Phenotype of Tumor Cells by Zonta, Francesca, Borgo, Christian, Quezada Meza, Camila Paz, Masgras, Ionica, Rasola, Andrea, Salvi, Mauro, Pinna, Lorenzo A, Ruzzene, Maria

“…CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and…”
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Fluctuations of entropy production in turbulent thermal convection by Zonta, Francesca, Chibbaro, Sergio

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Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin by Cozza, Giorgio, Zonta, Francesca, Dalle Vedove, Andrea, Venerando, Andrea, Dall'Acqua, Stefano, Battistutta, Roberto, Ruzzene, Maria, Lolli, Graziano

“…Protein kinase CK2 is an antiapoptotic cancer‐sustaining protein. Curcumin, reported previously as a CK2 inhibitor, is too bulky to be accommodated in the CK2…”
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Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach by Di Paolo, Maria Luisa, Cozza, Giorgio, Milelli, Andrea, Zonta, Francesca, Sarno, Stefania, Minniti, Elirosa, Ursini, Fulvio, Rosini, Michela, Minarini, Anna

“…The two human monoamine oxidase isoforms (namely MAO A and MAO B) are enzymes involved in the catabolism of monoamines, including neurotransmitters, and for…”
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Epigenetic heterogeneity affects the risk of relapse in children with t(8;21)RUNX1-RUNX1T1-rearranged AML by Zampini, Matteo, Tregnago, Claudia, Bisio, Valeria, Simula, Luca, Borella, Giulia, Manara, Elena, Zanon, Carlo, Zonta, Francesca, Serafin, Valentina, Accordi, Benedetta, Campello, Silvia, Buldini, Barbara, Pession, Andrea, Locatelli, Franco, Basso, Giuseppe, Pigazzi, Martina

“…The somatic translocation t(8;21)(q22;q22)/ RUNX1-RUNX1T1 is one of the most frequent rearrangements found in children with standard-risk acute myeloid…”
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Pathophysiological implications of mitochondrial oxidative stress mediated by mitochondriotropic agents and polyamines: the role of tyrosine phosphorylation by Grancara, Silvia, Zonta, Francesca, Ohkubo, Shinji, Brunati, Anna Maria, Agostinelli, Enzo, Toninello, Antonio

“…Mitochondria, once merely considered as the “powerhouse” of cells, as they generate more than 90 % of cellular ATP, are now known to play a central role in…”
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Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemia by Zonta, Francesca, Pagano, Mario Angelo, Trentin, Livio, Tibaldi, Elena, Frezzato, Federica, Gattazzo, Cristina, Martini, Veronica, Trimarco, Valentina, Mazzorana, Marco, Bordin, Luciana, Semenzato, Gianpietro, Brunati, Anna Maria

“…Lyn, a member of the group of tyrosine kinases named the Src family kinases (SFKs), is overexpressed, associated with an aberrant multiprotein complex and…”
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Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole by Frezzato, Federica, Trimarco, Valentina, Martini, Veronica, Gattazzo, Cristina, Ave, Elisa, Visentin, Andrea, Cabrelle, Anna, Olivieri, Valeria, Zambello, Renato, Facco, Monica, Zonta, Francesca, Cristiani, Andrea, Brunati, Anna Maria, Moro, Stefano, Semenzato, Gianpietro, Trentin, Livio

“…Summary Functional abnormalities of chronic lymphocytic leukaemia (CLL) cells may be related to the microtubular network of cell cytoskeleton; specifically…”
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Interaction between the SH3 domain of Src family kinases and the proline-rich motif of HTLV-1 p13: a novel mechanism underlying delivery of Src family kinases to mitochondria by Tibaldi, Elena, Venerando, Andrea, Zonta, Francesca, Bidoia, Carlo, Magrin, Elisa, Marin, Oriano, Toninello, Antonio, Bordin, Luciana, Martini, Veronica, Pagano, Mario Angelo, Brunati, Anna Maria

“…The association of the SH3 (Src homology 3) domain of SFKs (Src family kinases) with protein partners bearing proline-rich motifs has been implicated in the…”
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Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and L yn inhibition by nocodazole by Frezzato, Federica, Trimarco, Valentina, Martini, Veronica, Gattazzo, Cristina, Ave, Elisa, Visentin, Andrea, Cabrelle, Anna, Olivieri, Valeria, Zambello, Renato, Facco, Monica, Zonta, Francesca, Cristiani, Andrea, Brunati, Anna Maria, Moro, Stefano, Semenzato, Gianpietro, Trentin, Livio

“…Functional abnormalities of chronic lymphocytic leukaemia ( CLL ) cells may be related to the microtubular network of cell cytoskeleton; specifically tubulin…”
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Effect of peroxides on spermine transport in rat brain and liver mitochondria by Battaglia, Valentina, Tibaldi, Elena, Grancara, Silvia, Zonta, Francesca, Brunati, Anna Maria, Martinis, Pamela, Bragadin, Marcantonio, Grillo, Maria Angelica, Tempera, Giampiero, Agostinelli, Enzo, Toninello, Antonio

“…The polyamine spermine is transported into the matrix of various types of mitochondria by a specific uniporter system identified as a protein channel. This…”
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Cortactin Is Overexpressed In Neoplastic Cells of Patients with B-Cell Chronic Lymphocytic Leukemia by Trentin, Livio, Gattazzo, Cristina, Martini, Veronica, Frezzato, Federica, Trimarco, Valentina, Cabrelle, Anna, Olivieri, Valeria, Zonta, Francesca, Tibaldi, Elena, Brunati, Anna Maria, Zambello, Renato, Semenzato, Gianpietro

“…Abstract 2436 Cortactin is an ubiquitous actin-binding protein that is encoded by EMS1 gene, localized in chromosome 11q13 region. Cortactin is expressed in…”
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