Search Results - "Zong, Xinying"

Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation by Malakar, Pushkar, Shilo, Asaf, Mogilevsky, Adi, Stein, Ilan, Pikarsky, Eli, Nevo, Yuval, Benyamini, Hadar, Elgavish, Sharona, Zong, Xinying, Prasanth, Kannanganattu V, Karni, Rotem

“…Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise contributions to oncogenesis are still emerging. Here we report that the lncRNA…”
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Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer by Jadaliha, Mahdieh, Zong, Xinying, Malakar, Pushkar, Ray, Tania, Singh, Deepak K, Freier, Susan M, Jensen, Tor, Prasanth, Supriya G, Karni, Rotem, Ray, Partha S, Prasanth, Kannanganattu V

“…MALAT1 (metastasis associated lung adenocarcinoma transcript1) is a conserved long non-coding RNA, known to regulate gene expression by modulating…”
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Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer by Li, Xiao Ling, Subramanian, Murugan, Jones, Matthew F., Chaudhary, Ritu, Singh, Deepak K., Zong, Xinying, Gryder, Berkley, Sindri, Sivasish, Mo, Min, Schetter, Aaron, Wen, Xinyu, Parvathaneni, Swetha, Kazandjian, Dickran, Jenkins, Lisa M., Tang, Wei, Elloumi, Fathi, Martindale, Jennifer L., Huarte, Maite, Zhu, Yuelin, Robles, Ana I., Frier, Susan M., Rigo, Frank, Cam, Maggie, Ambs, Stefan, Sharma, Sudha, Harris, Curtis C., Dasso, Mary, Prasanth, Kannanganattu V., Lal, Ashish

“…Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest,…”
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Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation by Li, Jun, Xu, Beisi, He, Minghong, Zong, Xinying, Cunningham, Trevor, Sha, Cher, Fan, Yiping, Cross, Richard, Hanna, Jacob H., Feng, Yongqiang

“…Regulatory T (Treg) cells play crucial roles in suppressing deleterious immune response. Here, we investigate how Treg cells are mechanistically induced…”
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SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles by Tripathi, Vidisha, Song, David Y, Zong, Xinying, Shevtsov, Sergey P, Hearn, Stephen, Fu, Xiang-Dong, Dundr, Miroslav, Prasanth, Kannanganattu V

“…The mammalian cell nucleus is compartmentalized into nonmembranous subnuclear domains that regulate key nuclear functions. Nuclear speckles are subnuclear…”
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Knockdown of nuclear-retained long noncoding RNAs using modified DNA antisense oligonucleotides by Zong, Xinying, Huang, Lulu, Tripathi, Vidisha, Peralta, Raechel, Freier, Susan M, Guo, Shuling, Prasanth, Kannanganattu V

“…Long noncoding RNAs (lncRNAs) have recently emerged as important players in diverse cellular processes. Among them, a large fraction of lncRNAs are localized…”
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RNA splicing control: Yet another gene regulatory role for long nuclear noncoding RNAs by Zong, Xinying, Tripathi, Vidisha, Prasanth, Kannanganattu V.

“…The mammalian genome harbors a large number of long non-coding RNAs (lncRNAs) that do not code for proteins, but rather they exert their function directly as…”
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The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway by Hao, Qinyu, Zong, Xinying, Sun, Qinyu, Lin, Yo-Chuen, Song, You Jin, Hashemikhabir, Seyedsasan, Hsu, Rosaline Yc, Kamran, Mohammad, Chaudhary, Ritu, Tripathi, Vidisha, Singh, Deepak Kumar, Chakraborty, Arindam, Li, Xiao Ling, Kim, Yoon Jung, Orjalo, Arturo V, Polycarpou-Schwarz, Maria, Moriarity, Branden S, Jenkins, Lisa M, Johansson, Hans E, Zhu, Yuelin J, Diederichs, Sven, Bagchi, Anindya, Kim, Tae Hoon, Janga, Sarath C, Lal, Ashish, Prasanth, Supriya G, Prasanth, Kannanganattu V

“…Cell cycle is a cellular process that is subject to stringent control. In contrast to the wealth of knowledge of proteins controlling the cell cycle, very…”
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Natural antisense RNA promotes 3′ end processing and maturation of MALAT1 lncRNA by Zong, Xinying, Nakagawa, Shinichi, Freier, Susan M., Fei, Jingyi, Ha, Taekjip, Prasanth, Supriya G., Prasanth, Kannanganattu V.

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Regulatory T cell suppressive capacity is governed by synergistic Foxp3 enhancers by Feng, Yongqiang, Zong, Xinying

“…Abstract Regulatory T (Treg) cells bearing a diverse antigen receptor repertoire suppress pathogenic T cells and maintain immune homeostasis during their long…”
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Cis -proteomics reveals novel transcriptional regulators of Treg development and function by Feng, Yongqiang, Zong, Xinying

“…Abstract The immune suppressive function of regulatory T (Treg) cells is governed by the Foxp3-depenent transcriptional programs that remain unclear, which…”
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Malat1 is not an essential component of nuclear speckles in mice by Nakagawa, Shinichi, Ip, Joanna Y, Shioi, Go, Tripathi, Vidisha, Zong, Xinying, Hirose, Tetsuro, Prasanth, Kannanganattu V

“…Malat1 is an abundant long, noncoding RNA that localizes to nuclear bodies known as nuclear speckles, which contain a distinct set of pre-mRNA processing…”
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A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance by Dikiy, Stanislav, Li, Jun, Bai, Lu, Jiang, Menglin, Janke, Laura, Zong, Xinying, Hao, Xiaolei, Hoyos, Beatrice, Wang, Zhong-Min, Xu, Beisi, Fan, Yiping, Rudensky, Alexander Y., Feng, Yongqiang

“…Activation of the STAT5 transcription factor downstream of the Interleukin-2 receptor (IL-2R) induces expression of Foxp3, a critical step in the…”
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Natural antisense RNA promotes 3' end processing and maturation of MALAT1 lncRNA by Zong, Xinying, Nakagawa, Shinichi, Freier, Susan M, Fei, Jingyi, Ha, Taekjip, Prasanth, Supriya G, Prasanth, Kannanganattu V

“…The RNase P-mediated endonucleolytic cleavage plays a crucial role in the 3' end processing and cellular accumulation of MALAT1, a nuclear-retained long…”
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Genetic tracing of thymic T cell differentiation by Jiang, Menglin, Keith, Julia, Zong, Xinying, Hao, Xiaolei, Li, Yichao, Bai, Lu, He, Minghong, Guy, Cliff, Li, Jun, Huang, Wenjun, Cheng, Yong, Feng, Yongqiang

“…Abstract Thymic T cell differentiation is controlled by stereotyped processes that remain obscure. Here we develop a novel mouse genetic tool to trace thymic T…”
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Dynamic Foxp3-chromatin interaction controls tunable Treg cell function by He, Minghong, Zong, Xinying, Xu, Beisi, Qi, Wenjie, Huang, Wenjun, Djekidel, Mohamed Nadhir, Zhang, Yang, Pagala, Vishwajeeth R, Li, Jun, Hao, Xiaolei, Guy, Clifford, Bai, Lu, Cross, Richard, Li, Chunliang, Peng, Junmin, Feng, Yongqiang

“…Nuclear factor Foxp3 determines regulatory T (Treg) cell fate and function via mechanisms that remain unclear. Here, we investigate the nature of…”
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Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacity by Zong, Xinying, Hao, Xiaolei, Xu, Beisi, Crawford, Jeremy Chase, Wright, Shaela, Li, Jun, Zhang, Yang, Bai, Lu, He, Minghong, Jiang, Menglin, Fan, Yiping, Connelly, Jon P, Pruett-Miller, Shondra M, Berns, Hartmut, Janke, Laura, Li, Chunliang, Feng, Yongqiang

“…T reg cells bearing a diverse antigen receptor repertoire suppress pathogenic T cells and maintain immune homeostasis during their long lifespan. How their…”
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Long noncoding RNA MALAT1 promotes hepatocellular carcinoma development by SRSF1 up-regulation and mTOR activation by Malakar, Pushkar, Shilo, Asaf, Mogilevsky, Adi, Stein, Ilan, Pikarsky, Eli, Nevo, Yuval, Benyamini, Hadar, Elgavish, Sharona, Zong, Xinying, Prasanth, Kannanganattu V., Karni, Rotem

“…Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise contributions to oncogenesis are still emerging. Here we report that the lncRNA…”
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Role of cancer‐associated nuclear‐retained RNA in pre‐mRNA splicing regulation by Prasanth, Kannanganattu V, Tripathi, Vidisha, Zong, Xinying, Shen, Zhen, Prasanth, Supriya G

“…Abstract only In eukaryotic cells, long ncRNAs (lncRNAs) play roles in crucial cellular processes and their aberrant expression is linked to several diseases…”
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