Search Results - "Zondag, Gerben C"
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Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution
Published in Science (American Association for the Advancement of Science) (22-11-2013)“…The molecular basis of antigenic drift was determined for the hemagglutinin (HA) of human influenza A/H3N2 virus. From 1968 to 2003, antigenic change was…”
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Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice
Published in Food and chemical toxicology (01-06-2011)“…Pomegranate seed oil has been shown to protect against diet induced obesity and insulin resistance. To characterize the metabolic effects of punicic acid on…”
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Multiantigen pan-sarbecovirus DNA vaccines generate protective T cell immune responses
Published in JCI insight (08-11-2023)“…SARS-CoV-2 is the third zoonotic coronavirus to cause a major outbreak in humans in recent years, and many more SARS-like coronaviruses with pandemic potential…”
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Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair
Published in The Journal of neuroscience (31-08-2011)“…Age-related cognitive decline and neurodegenerative diseases are a growing challenge for our societies with their aging populations. Accumulation of DNA damage…”
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A novel nutritional supplement prevents muscle loss and accelerates muscle mass recovery in caloric-restricted mice
Published in Metabolism, clinical and experimental (01-08-2019)“…Muscle atrophy is defined as decreased muscle mass, associated with aging as well as with various chronic diseases and is a fundamental cause of frailty,…”
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Neoantigen-specific T cell help outperforms non-specific help in multi-antigen DNA vaccination against cancer
Published in Molecular Therapy: Oncology (19-09-2024)“…CD4 T helper antigens are essential components of cancer vaccines, but the relevance of the source of these MHC class II-restricted antigens remains…”
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A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection
Published in Nature communications (08-07-2022)“…Understanding the mechanisms and impact of booster vaccinations are essential in the design and delivery of vaccination programs. Here we show that a three…”
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Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial-Mesenchymal Transition
Published in The Journal of cell biology (15-05-2000)“…Proteins of the Rho family regulate cytoskeletal rearrangements in response to receptor stimulation and are involved in the establishment and maintenance of…”
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9
Multi-antigen pan-sarbecovirus DNA vaccines generate protective T cell immune responses
Published in JCI insight (14-09-2023)“…SARS-CoV-2 is the third zoonotic coronavirus to cause a major outbreak in humans in recent years, and many more SARS-like coronaviruses with pandemic potential…”
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10
Purification and characterization of the cytoplasmic domain of human receptorlike protein tyrosine phosphatase RPTP.mu
Published in Biochemistry (Easton) (01-12-1993)Get full text
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Lysophosphatidic acid: G-protein signalling and cellular responses
Published in Current opinion in cell biology (01-04-1997)“…Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates a specific G protein coupled receptor to evoke multiple cellular responses. Recent…”
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Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1
Published in Biochemical journal (01-03-1998)“…Sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) are structurally related lipid mediators that act on distinct G-protein-coupled receptors to…”
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Acute Loss of Cell-Cell Communication Caused by G Protein-Coupled Receptors: A Critical Role for c-Src
Published in The Journal of cell biology (09-03-1998)“…Gap junctions mediate cell-cell communication in almost all tissues, but little is known about their regulation by physiological stimuli. Using a novel…”
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14
Lack of association between receptor protein tyrosine phosphatase RPTPmu and cadherins
Published in The Journal of cell biology (01-09-1996)“…Zondag et al show that RPTPmu, a receptor-like protein tyrosine phosphatase, does not interact with cadherin/catenin complexes, even when assayed under very…”
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Cell surface expression of receptor protein tyrosine phosphatase RPTPmu is regulated by cell-cell contact
Published in The Journal of cell biology (01-10-1995)“…RPTPmu is a transmembrane protein tyrosine phosphatase with an adhesion molecule-like ectodomain. Gebbink et al examine how RPTPmu may function as a cell…”
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Cell Surface Expression of Receptor Protein Tyrosine Phosphatase RPTPμ Is Regulated by Cell-Cell Contact
Published in The Journal of cell biology (01-10-1995)“…RPTPμ is a transmembrane protein tyrosine phosphatase with an adhesion molecule-like ectodomain. It has recently been shown that RPTPμ mediates homophilic…”
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Receptor Protein-tyrosine Phosphatase RPTPμ Binds to and Dephosphorylates the Catenin p120 ctn
Published in The Journal of biological chemistry (14-04-2000)“…RPTPμ is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPμ consists of a…”
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Intramolecular Interactions between the Juxtamembrane Domain and Phosphatase Domains of Receptor Protein-tyrosine Phosphatase RPTPÎ
Published in The Journal of biological chemistry (19-05-2000)“…RPTPμ is a receptor-like protein-tyrosine phosphatase (RPTP) whose ectodomain mediates homotypic cell-cell interactions. The intracellular part of RPTPμ…”
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Lack of Association between Receptor Protein Tyrosine Phosphatase RPTPμ and Cadherins
Published in The Journal of cell biology (01-09-1996)“…RPTPμ is a receptor-like protein tyrosine phosphatase that mediates homophilic cell-cell interactions. Surface expression of RPTPμ is restricted to cell-cell…”
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Homophilic Interactions Mediated by Receptor Tyrosine Phosphatases and . A CRITICAL ROLE FOR THE NOVEL EXTRACELLULAR MAM DOMAIN
Published in The Journal of biological chemistry (16-06-1995)“…The receptor-like protein tyrosine phosphatases (RPTP) μ and RPTPκ have a modular ectodomain consisting of four fibronectin type III-like repeats, a single…”
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