Search Results - "Zoghebi, Khalid"

Design and Biological Evaluation of Colchicine-CD44-Targeted Peptide Conjugate in an In Vitro Model of Crystal Induced Inflammation by Zoghebi, Khalid A, Bousoik, Emira, Parang, Keykavous, Elsaid, Khaled A

“…Gout is an inflammatory arthritis due to the joint deposition of monosodium urate (MSU) crystals. Phagocytosis of MSU crystals by tissue macrophages results in…”
Get full text

Targeting PD-1/PD-L-1 immune checkpoint inhibition for cancer immunotherapy: success and challenges by Javed, Sadique A, Najmi, Asim, Ahsan, Waquar, Zoghebi, Khalid

“…The programmed death-1 receptor (PD-1) acts as a T-cell brake, and its interaction with ligand-1 (PD-L-1) interferes with signal transduction of the T-cell…”
Get full text

Insights into the Effects of Ligand Binding on Leucyl-tRNA Synthetase Inhibitors for Tuberculosis: In Silico Analysis and Isothermal Titration Calorimetry Validation by Rehman, Zia Ur, Najmi, Asim, Zoghebi, Khalid

“…Incidences of drug-resistant tuberculosis have become common and are rising at an alarming rate. Aminoacyl t-RNA synthetase has been validated as a newer…”
Get full text

Hydrophobic interactions between the HA helix and S4‐S5 linker modulate apparent Ca2+ sensitivity of SK2 channels by Nam, Young‐Woo, Cui, Meng, Orfali, Razan, Viegas, Adam, Nguyen, Misa, Mohammed, Eman H. M., Zoghebi, Khalid A., Rahighi, Simin, Parang, Keykavous, Zhang, Miao

“…Aim Small‐conductance Ca2+‐activated potassium (SK) channels are activated exclusively by increases in intracellular Ca2+ that binds to calmodulin…”
Get full text

[(WR) 8 WKβA]-Doxorubicin Conjugate: A Delivery System to Overcome Multi-Drug Resistance against Doxorubicin by Zoghebi, Khalid, Aliabadi, Hamidreza Montazeri, Tiwari, Rakesh Kumar, Parang, Keykavous

“…Doxorubicin (Dox) is an anthracycline chemotherapeutic agent used to treat breast, leukemia, and lymphoma malignancies. However, cardiotoxicity and inherent…”
Get full text

Improved Photocatalytic and Antioxidant Activity of Olive Fruit Extract-Mediated ZnO Nanoparticles by Ghaffar, Sadia, Abbas, Azhar, Naeem-Ul-Hassan, Muhammad, Assad, Nasir, Sher, Muhammad, Ullah, Sami, Alhazmi, Hassan A, Najmi, Asim, Zoghebi, Khalid, Al Bratty, Mohammed, Hanbashi, Ali, Makeen, Hafiz A, Amin, Hatem M A

“…Photodegradation is an efficient strategy for the removal of organic pollutants from wastewater. Due to their distinct properties and extensive applications,…”
Get full text

Exploring LIPIDs for their potential to improves bioavailability of lipophilic drugs candidates: A review by Preeti, Sambhakar, Sharda, Saharan, Renu, Narwal, Sonia, Malik, Rohit, Gahlot, Vinod, Khalid, Asaad, Najmi, Asim, Zoghebi, Khalid, Halawi, Maryam A., Albratty, Mohammed, Mohan, Syam

“…This review aims to provide a thorough examination of the benefits, challenges, and advancements in utilizing lipids for more effective drug delivery,…”
Get full text

Amphiphilic Cell-Penetrating Peptides Containing Arginine and Hydrophobic Residues as Protein Delivery Agents by Moreno, Jonathan, Zoghebi, Khalid, Salehi, David, Kim, Lois, Shoushtari, Sorour Khayyatnejad, Tiwari, Rakesh K, Parang, Keykavous

“…The entry of proteins through the cell membrane is challenging, thus limiting their use as potential therapeutics. Seven cell-penetrating peptides, designed in…”
Get full text

Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression by Jain, Nem Kumar, Tailang, Mukul, Chandrasekaran, Balakumar, Khazaleh, Nasha't, Thangavel, Neelaveni, Makeen, Hafiz A, Albratty, Mohammed, Najmi, Asim, Alhazmi, Hassan Ahmad, Zoghebi, Khalid, Alagusundaram, M, Jain, Hemant Kumar

“…Alchornea laxiflora (Benth.) Pax & K. Hoffm. (A. laxiflora) has been indicated in traditional medicine to treat depression. However, scientific rationalization…”
Get full text

A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality by Jain, Nem Kumar, Tailang, Mukul, Thangavel, Neelaveni, Makeen, Hafiz A., Albratty, Mohammed, Najmi, Asim, Alhazmi, Hassan Ahmad, Zoghebi, Khalid, Alagusundaram, Muthumanickam, Jain, Hemant Kumar, Chandrasekaran, Balakumar

“…The arrival of comprehensive genome sequencing has accelerated the understanding of genetically aberrant advanced cancers and target identification for…”
Get full text

Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca 2+ sensitivity of SK2 channels by Nam, Young-Woo, Cui, Meng, Orfali, Razan, Viegas, Adam, Nguyen, Misa, Mohammed, Eman H M, Zoghebi, Khalid A, Rahighi, Simin, Parang, Keykavous, Zhang, Miao

“…Small-conductance Ca -activated potassium (SK) channels are activated exclusively by increases in intracellular Ca that binds to calmodulin constitutively…”
Get full text

Virosome: An engineered virus for vaccine delivery by Ali, Hasan, Akbar, Md, Iqbal, Babar, Ali, Faraat, Sharma, Neeraj Kant, Kumar, Nitin, Najmi, Asim, Albratty, Mohammed, Alhazmi, Hassan A., Madkhali, Osama A., Zoghebi, Khalid, Alam, Md Shamsher

“…The purpose of immunization is the effective cellular and humoral immune response against antigens. Several studies on novel vaccine delivery approaches such…”
Get full text

Enhancement of antifungal activity and transdermal delivery of 5-flucytosine via tailored spanlastic nanovesicles: statistical optimization, in-vitro characterization, and in-vivo biodistribution study by Safhi, Awaji Y, Naveen, Nimbagal Raghavendra, Rolla, Krishna Jayanth, Bhavani, Penmetsa Durga, Kurakula, Mallesh, Hosny, Khaled M, Abualsunun, Walaa A, Alissa, Mohammed, Alsalhi, Abdullah, Alahmadi, Amerh Aiad, Zoghebi, Khalid, Halwaani, Abdulrahman Sindam, Ibrahim K, Rasha

“…This current study aimed to load 5-flucytosine (5-FCY) into spanlastic nanovesicles (SPLNs) to make the drug more efficient as an antifungal and also to load…”
Get full text

Central composite design (CCD) approach to develop HPLC method for caffeine: Application to coffee samples analysis of Jazan region, Saudi Arabia by Najmi, Asim, Rehman, Zia ur, Zoghebi, Khalid, Alhazmi, Hassan Ahmed, Albratty, Mohammed Mofarreh, Haroobi, Qasem Yahya Hassan, Sayram, Ismail Mohammed Ali, Saleh, Mohammed Ahmed, Qaser, Waleed Mohammed Ahmed, Qaysi, Abdulaziz Ali Houssein

“…The goal of this study was to use High performance liquid chromatography (HPLC) with an Analytical Quality by Design (AQbD) approach to measure the amount of…”
Get full text

Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study by Safhi, Awaji Y, Siddique, Waqar, Zaman, Muhammad, Sarfraz, Rai Muhammad, Shafeeq Ur Rahman, Muhammad, Mahmood, Asif, Salawi, Ahmad, Sabei, Fahad Y, Alsalhi, Abdullah, Zoghebi, Khalid

“…A migraine is a condition of severe headaches, causing a disturbance in the daily life of the patient. The current studies were designed to develop…”
Get full text

Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Agents by Salehi, David, Mozaffari, Saghar, Zoghebi, Khalid, Lohan, Sandeep, Mandal, Dindyal, Tiwari, Rakesh K, Parang, Keykavous

“…A series of cyclic peptides, [(DipR)(WR) ], [(DipR) (WR) ], [(DipR) (WR) ], [(DipR) (WR)], and [DipR] , and their linear counterparts containing arginine (R)…”
Get full text

Spectral characterization, analgesic, and anti-inflammatory effects of ethanolic extract of Calotropis procera leaf and dry latex from Jazan, Kingdom of Saudi Arabia by ALAM, Md S., RAJHI, Bassam R., ALAM, Mohammad F., HAMZI, Malik M., ALBRATTY, Mohammed, ALHAZMI, Hassan A., NAJMI, Asim, ZOGHEBI, Khalid, REHMAN, Zia ur, MONI, Sivakumar S.

“…Traditional healers have used the shrub Calotropis procera (CP) for many years for various therapies. The present study investigated the bioactive constituents…”
Get full text

Phytoimmunomodulators: A review of natural modulators for complex immune system by Hooda, Partibha, Malik, Rohit, Bhatia, Saurabh, Al-Harrasi, Ahmed, Najmi, Asim, Zoghebi, Khalid, Halawi, Maryam A., Makeen, Hafiz A., Mohan, Syam

“…In the past few decades, the medicinal properties of plants and their effects on the human immune system are being studied extensively. Plants are an…”
Get full text

Daidzein from Dietary Supplement to a Drug Candidate: An Evaluation of Potential by Ubaid, Mohammed, Salauddin, Shadani, Md Andalib, Kawish, S. M., Albratty, Mohammed, Makeen, Hafiz A., Alhazmi, Hassan A., Najmi, Asim, Zoghebi, Khalid, Halawi, Maryam A., Ali, Abuzer, Alam, Md Shamsher, Iqbal, Zeenat, Mirza, Mohd. Aamir

“…Daidzein (DDZ) is a well-known nutraceutical supplement belonging to the class of isoflavones. It is isolated from various sources such as alfalfa, soybean,…”
Get full text

Cyclic Peptide-Gadolinium Nanoparticles for Enhanced Intracellular Delivery by Shirazi, Amir Nasrolahi, Park, Shang Eun, Rad, Shirin, Baloyan, Luiza, Mandal, Dindyal, Sajid, Muhammad Imran, Hall, Ryley, Lohan, Sandeep, Zoghebi, Khalid, Parang, Keykavous, Tiwari, Rakesh Kumar

“…A cyclic peptide containing one cysteine and five alternating tryptophan and arginine amino acids [(WR)5C] was synthesized using Fmoc/tBu solid-phase…”
Get full text