Search Results - "Zoeller, Raphael"

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway by Nakahara, Kanae, Ohkuni, Aya, Kitamura, Takuya, Abe, Kensuke, Naganuma, Tatsuro, Ohno, Yusuke, Zoeller, Raphael A., Kihara, Akio

“…Sphingosine 1-phosphate (S1P) functions not only as a bioactive lipid molecule, but also as an important intermediate of the sole sphingolipid-to-glycerolipid…”
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The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens by Werner, Ernst R., Keller, Markus A., Sailer, Sabrina, Lackner, Katharina, Koch, Jakob, Hermann, Martin, Coassin, Stefan, Golderer, Georg, Werner-Felmayer, Gabriele, Zoeller, Raphael A., Hulo, Nicolas, Berger, Johannes, Watschinger, Katrin

“…A significant fraction of the glycerophospholipids in the human body is composed of plasmalogens, particularly in the brain, cardiac, and immune cell…”
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A novel assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates by Werner, Ernst R., Keller, Markus A., Sailer, Sabrina, Seppi, Daniele, Golderer, Georg, Werner-Felmayer, Gabriele, Zoeller, Raphael A., Watschinger, Katrin

“…Plasmanylethanolamine desaturase (PEDS) (EC 1.14.99.19) introduces the 1-prime double bond into plasmalogens, one of the most abundant phospholipids in the…”
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Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes by Krawczyk, Sarah A, Haller, Jorge F, Ferrante, Tom, Zoeller, Raphael A, Corkey, Barbara E

“…In obesity, there is an increase in reactive oxygen species (ROS) within adipose tissue caused by increases in inflammation and overnutrition. Hormone…”
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Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum by Honsho, Masanori, Tanaka, Megumi, Zoeller, Raphael A., Fujiki, Yukio

“…Plasmalogens are a subclass of ether glycerophospholipids characterized by a vinyl-ether bond at the sn -1 position of the glycerol backbone. Plasmalogen…”
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Plasmalogens: biosynthesis and functions by Nagan, Narasimhan, Zoeller, Raphael A

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A cell-based high-throughput screen identifies tyrphostin AG 879 as an inhibitor of animal cell phospholipid and fatty acid biosynthesis by Zoeller, Raphael A, Geoghegan-Barek, Kathleen

“…Inhibition of animal cell phospholipid biosynthesis has been proposed for anticancer and antiviral therapies. Using CHO-K1 derived cell lines, we have…”
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Endothelial Cell Protein Targeting by Myeloperoxidase-Derived 2-Chlorofatty Aldehyde by Shakya, Shubha, Herr, Roger A, Carlson, Haley L, Zoeller, Raphael A, Albert, Carolyn J, Ford, David A

“…Neutrophils are important cellular mediators of injury and repair in diseases including ischemic heart disease, atherosclerosis, and sepsis…”
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Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal by Anbukumar, Dhanalakshmi S., Shornick, Laurie P., Albert, Carolyn J., Steward, Melissa M., Zoeller, Raphael A., Neumann, William L., Ford, David A.

“…Neutrophils are important in the host response against invading pathogens. One chemical defense mechanism employed by neutrophils involves the production of…”
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Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1α to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease by Haller, Jorge F., Krawczyk, Sarah A., Gostilovitch, Lubov, Corkey, Barbara E., Zoeller, Raphael A.

“…Inherited glucose-6-phosphate isomerase (GPI) deficiency is the second most frequent glycolytic erythroenzymopathy in humans. Patients present with…”
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On the importance of plasmalogen status in stimulated arachidonic acid release in the macrophage cell line RAW 264.7 by Gaposchkin, Daniel P., Farber, Harrison W., Zoeller, Raphael A.

“…We examined the dependence of stimulated arachidonic acid release on plasmalogens using the murine, macrophage cell line 264.7 and two plasmalogen-deficient…”
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Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport by Munn, Natalie J, Arnio, Emily, Liu, Dailan, Zoeller, Raphael A, Liscum, Laura

“…Plasmalogens are a major sub-class of ethanolamine and choline phospholipids in which the sn-1 position has a long chain fatty alcohol attached through a vinyl…”
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Isolation of Novel Animal Cell Lines Defective in Glycerolipid Biosynthesis Reveals Mutations in Glucose-6-phosphate Isomerase by Haller, Jorge F., Smith, Conor, Liu, Dailan, Zheng, Hongying, Tornheim, Keith, Han, Gil-Soo, Carman, George M., Zoeller, Raphael A.

“…Glycerolipids are structural components for membranes and serve in energy storage. We describe here the use of a photodynamic selection technique to generate a…”
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Increasing plasmalogen levels protects human endothelial cells during hypoxia by Zoeller, Raphael A, Grazia, Todd J, LaCamera, Peter, Park, James, Gaposchkin, Daniel P, Farber, Harrison W

“…Supplementation of cultured human pulmonary arterial endothelial cells (PAEC) with sn-1-O-hexadecylglycerol (HG) resulted in an approximately twofold increase…”
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Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids by Liu, Dailan, Nagan, Narasimhan, Just, Wilhelm W., Rodemer, Claus, Thai, Thanh-Phuong, Zoeller, Raphael A.

“…The variant CHO-K1 cell line, NRel-4, is unable to synthesize plasmalogens because of a severe reduction in dihydroxyacetonephosphate acyltransferase (DHAPAT)…”
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Attenuation of Hemolysis Due to Glucose‐6‐Phosphate Isomerase Deficiency With Ketogenic Diet – A Case Report by Park, Hyun, Haller, Jorge, Smith, Frances, Parkin, Nicholas, Lythe, Toyin, Zoeller, Raphael Andrew, Chakravorty, Subarna

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Synthesis and biological properties of the fluorescent ether lipid precursor 1-O-[9'-(1''-pyrenyl)]nonyl-sn-glycerol by Zheng, Hongying, Duclos, Richard I, Smith, Conor C, Farber, Harrison W, Zoeller, Raphael A

“…The synthesis of an [omega]-pyrene-labeled 1-O-alkyl-sn-glycerol was performed using a chirospecific method starting from…”
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Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line. Insights using ether lipid-deficient variants by Gaposchkin, D P, Zoeller, R A

“…Previously, this laboratory reported the isolation of variants, RAW. 12 and RAW.108, from the macrophage-like cell line RAW 264.7 that are defective in…”
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Ultradiffuse Galaxies—A Distinct Population? Dwarf Galaxies in the Coma Cluster and A262 from Deep u′–g′–r′ Wendelstein Imaging Data by Zöller, Raphael, Kluge, Matthias, Staiger, Benjamin, Bender, Ralf

“…Abstract In this study, we compare the structural parameters of ultradiffuse galaxies (UDGs) to those of other dwarf galaxies and investigate whether UDGs form…”
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Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2-trans-Hexadecenal by Jarugumilli, Gopala Krishna, Choi, Jong-Ryoul, Chan, PuiYee, Yu, Meilan, Sun, Yang, Chen, Baoen, Niu, Jixiao, DeRan, Michael, Zheng, Baohui, Zoeller, Raphael, Lin, Cheng, Wu, Xu

“…Lipid-derived electrophiles (LDEs) are reactive metabolites, which can covalently modify proteins and DNA and regulate diverse cellular processes…”
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