Search Results - "Zoch, Ansgar"

TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing by Schöpp, Theresa, Zoch, Ansgar, Berrens, Rebecca V., Auchynnikava, Tania, Kabayama, Yuka, Vasiliauskaitė, Lina, Rappsilber, Juri, Allshire, Robin C., O’Carroll, Dónal

“…The PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of young active transposable elements (TEs) in the male…”
Get full text

Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility by Stallmeyer, Birgit, Bühlmann, Clara, Stakaitis, Rytis, Dicke, Ann-Kristin, Ghieh, Farah, Meier, Luisa, Zoch, Ansgar, MacKenzie MacLeod, David, Steingröver, Johanna, Okutman, Özlem, Fietz, Daniela, Pilatz, Adrian, Riera-Escamilla, Antoni, Xavier, Miguel J., Ruckert, Christian, Di Persio, Sara, Neuhaus, Nina, Gurbuz, Ali Sami, Şalvarci, Ahmet, Le May, Nicolas, McEleny, Kevin, Friedrich, Corinna, van der Heijden, Godfried, Wyrwoll, Margot J., Kliesch, Sabine, Veltman, Joris A., Krausz, Csilla, Viville, Stéphane, Conrad, Donald F., O’Carroll, Dónal, Tüttelmann, Frank

“…piRNAs are crucial for transposon silencing, germ cell maturation, and fertility in male mice. Here, we report on the genetic landscape of piRNA dysfunction in…”
Get full text

Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation by Zoch, Ansgar, Mayerl, Steffen, Schulz, Alexander, Greither, Thomas, Frappart, Lucien, Rübsam, Juliane, Heuer, Heike, Giovannini, Marco, Morrison, Helen

“…The tumour suppressor Merlin, encoded by the gene NF2, is frequently mutated in the autosomal dominant disorder neurofibromatosis type II, characterised…”
Get full text

CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins by Riecken, Lars Björn, Zoch, Ansgar, Wiehl, Ulrike, Reichert, Sabine, Scholl, Ingmar, Cui, Yan, Ziemer, Mirjana, Anderegg, Ulf, Hagel, Christian, Morrison, Helen

Get full text

PIWI-interacting RNAs: small RNAs with big functions by Ozata, Deniz M., Gainetdinov, Ildar, Zoch, Ansgar, O’Carroll, Dónal, Zamore, Phillip D.

“…In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence transposable elements, regulate gene expression and fight viral infection…”
Get full text

Merlin's wizardry guides cohesive migration by Zoch, Ansgar, Morrison, Helen

“…Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be…”
Get full text

SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation by Zoch, Ansgar, Auchynnikava, Tania, Berrens, Rebecca V., Kabayama, Yuka, Schöpp, Theresa, Heep, Madeleine, Vasiliauskaitė, Lina, Pérez-Rico, Yuvia A., Cook, Atlanta G., Shkumatava, Alena, Rappsilber, Juri, Allshire, Robin C., O’Carroll, Dónal

“…In mammals, the acquisition of the germline from the soma provides the germline with an essential challenge: the need to erase and reset genomic methylation 1…”
Get full text

MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis by Vrettos, Nicholas, Oppelt, Jan, Zoch, Ansgar, Sgourdou, Paraskevi, Yoshida, Haruka, Song, Brian, Fink, Ryan, O'Carroll, Dónal, Mourelatos, Zissimos

“…N-terminal arginine (NTR) methylation is a conserved feature of PIWI proteins, which are central components of the PIWI-interacting RNA (piRNA) pathway. The…”
Get full text

Transduction of peptides and proteins into live cells by cell penetrating peptides by Mussbach, Franziska, Franke, Martin, Zoch, Ansgar, Schaefer, Buerk, Reissmann, Siegmund

“…Internalization of peptides and proteins into live cells is an essential prerequisite for studies on intracellular signal pathways, for treatment of certain…”
Get full text

Two-factor authentication underpins the precision of the piRNA pathway by Dias Mirandela, Madeleine, Zoch, Ansgar, Leismann, Jessica, Webb, Shaun, Berrens, Rebecca V., Valsakumar, Devisree, Kabayama, Yuka, Auchynnikava, Tania, Schito, Martina, Chowdhury, Tamoghna, MacLeod, David, Xiang, Xinyu, Zou, Juan, Rappsilber, Juri, Allshire, Robin C., Voigt, Philipp, Cook, Atlanta G., Barau, Joan, O’Carroll, Dónal

“…The PIWI-interacting RNA (piRNA) pathway guides the DNA methylation of young, active transposons during germline development in male mice 1 . piRNAs tether the…”
Get full text

C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line by Zoch, Ansgar, Konieczny, Gabriela, Auchynnikava, Tania, Stallmeyer, Birgit, Rotte, Nadja, Heep, Madeleine, Berrens, Rebecca V, Schito, Martina, Kabayama, Yuka, Schöpp, Theresa, Kliesch, Sabine, Houston, Brendan, Nagirnaja, Liina, O'Bryan, Moira K, Aston, Kenneth I, Conrad, Donald F, Rappsilber, Juri, Allshire, Robin C, Cook, Atlanta G, Tüttelmann, Frank, O'Carroll, Dónal

“…In the male mouse germ line, PIWI-interacting RNAs (piRNAs), bound by the PIWI protein MIWI2 (PIWIL4), guide DNA methylation of young active transposons…”
Get more information

A neuronal function of the tumor suppressor protein merlin by Schulz, Alexander, Zoch, Ansgar, Morrison, Helen

“…Mutagenic loss of the NF2 tumor suppressor gene encoded protein merlin is known to provoke the hereditary neoplasia syndrome, Neurofibromatosis type 2 (NF2)…”
Get full text

Cluster of differentiation 44 promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin by Ma, Junzhi, Klemm, Janina, Gerardo‐Ramírez, Monserrat, Frappart, Lucien, Castven, Darko, Becker, Diana, Zoch, Ansgar, Parent, Romain, Bartosch, Birke, Minnich, Kerstin, Giovannini, Marco, Danckwardt, Sven, Hartmann, Nils, Morrison, Helen, Herrlich, Peter, Marquardt, Jens U., Hartmann, Monika

“…Merlin is a versatile tumor suppressor protein encoded by the NF2 gene. Several lines of evidence suggest that Merlin exerts its tumor suppressor activity, at…”
Get full text

Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling by SCHULZ, Alexander, KYSELYOVA, Anna, BAADER, Stephan L, JUNG, Marie Juliane, ZOCH, Ansgar, VICTOR-FELIX, Mautner, HAGEL, Christian, MORRISON, Helen

“…Axonal surface proteins encompass a group of heterogeneous molecules, which exert a variety of different functions in the highly interdependent relationship…”
Get full text

Merlin isoform 2 in neurofibromatosis type 2–associated polyneuropathy by Schulz, Alexander, Baader, Stephan L, Niwa-Kawakita, Michiko, Jung, Marie Juliane, Bauer, Reinhard, Garcia, Cynthia, Zoch, Ansgar, Schacke, Stephan, Hagel, Christian, Mautner, Victor-Felix, Hanemann, C Oliver, Dun, Xin-Peng, Parkinson, David B, Weis, Joachim, Schröder, J Michael, Gutmann, David H, Giovannini, Marco, Morrison, Helen

“…Neurofibromatosis type 2 (NF2) is caused by inactivation of the NF2 gene, which encodes merlin. NF2 patients develop peripheral neuropathies. The authors show…”
Get full text

CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins by Riecken, Lars Björn, Zoch, Ansgar, Wiehl, Ulrike, Reichert, Sabine, Scholl, Ingmar, Cui, Yan, Ziemer, Mirjana, Anderegg, Ulf, Hagel, Christian, Morrison, Helen

“…Hyperactive Ras signaling has strong oncogenic effects causing several different forms of cancer. Hyperactivity is frequently induced by mutations within Ras…”
Get full text

Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation: e0129151 by Zoch, Ansgar, Mayerl, Steffen, Schulz, Alexander, Greither, Thomas, Frappart, Lucien, Ruebsam, Juliane, Heuer, Heike, Giovannini, Marco, Morrison, Helen

“…The tumour suppressor Merlin, encoded by the gene NF2, is frequently mutated in the autosomal dominant disorder neurofibromatosis type II, characterised…”
Get full text