Search Results - "Zoccoli, Giovanna"
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1
Neural control of fasting-induced torpor in mice
Published in Scientific reports (29-10-2019)“…Torpor is a peculiar mammalian behaviour, characterized by the active reduction of metabolic rate, followed by a drop in body temperature. To enter torpor, the…”
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2
Early-life nicotine or cotinine exposure produces long-lasting sleep alterations and downregulation of hippocampal corticosteroid receptors in adult mice
Published in Scientific reports (13-12-2021)“…Early-life exposure to environmental toxins like tobacco can permanently re-program body structure and function. Here, we investigated the long-term effects on…”
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3
Obstructive sleep apneas naturally occur in mice during REM sleep and are highly prevalent in a mouse model of Down syndrome
Published in Neurobiology of disease (01-11-2021)“…The use of mouse models in sleep apnea study is limited by the belief that central (CSA) but not obstructive sleep apneas (OSA) occur in rodents. We aimed to…”
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4
Effects of ambient temperature on sleep and cardiovascular regulation in mice: the role of hypocretin/orexin neurons
Published in PloS one (08-10-2012)“…The central neural pathways underlying the physiological coordination between thermoregulation and the controls of the wake-sleep behavior and cardiovascular…”
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5
CDKL5 deficiency entails sleep apneas in mice
Published in Journal of sleep research (01-08-2017)“…Summary A recently discovered neurodevelopmental disorder caused by the mutation of the cyclin‐dependent kinase‐like 5 gene (CDKL5) entails complex…”
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6
Increased hippocampal epigenetic age in the Ts65Dn mouse model of Down Syndrome
Published in Frontiers in aging neuroscience (21-05-2024)“…Down syndrome (DS) is a segmental progeroid genetic disorder associated with multi-systemic precocious aging phenotypes, which are particularly evident in the…”
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7
Gender medicine and sleep disorders: from basic science to clinical research
Published in Frontiers in neurology (10-07-2024)“…Several pivotal differences in sleep and sleep disorders are recognized between women and men. This is not only due to changes in hormonal balance during…”
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8
Modulation of sympathetic vasoconstriction is critical for the effects of sleep on arterial pressure in mice
Published in The Journal of physiology (15-02-2018)“…Key points While values of arterial pressure during sleep are predictive of cardiovascular risk, the autonomic mechanisms underlying the cardiovascular effects…”
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Accurate discrimination of the wake-sleep states of mice using non-invasive whole-body plethysmography
Published in Scientific reports (31-01-2017)“…A major limitation in the study of sleep breathing disorders in mouse models of pathology is the need to combine whole-body plethysmography (WBP) to measure…”
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10
Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder
Published in International journal of molecular sciences (01-03-2023)“…CDKL5 (cyclin-dependent kinase-like 5) deficiency disorder (CDD) is a severe neurodevelopmental disease that mostly affects girls, who are heterozygous for…”
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11
The physiological signature of daily torpor is not orexin dependent
Published in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology (01-07-2020)“…Under conditions of scarce food availability and cool ambient temperature, the mouse ( Mus Musculus ) enters into torpor, a state of transient metabolic…”
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12
Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder
Published in Neural plasticity (01-01-2018)“…CDKL5 disorder is a severe neurodevelopmental disorder caused by mutations in the X-linked CDKL5 (cyclin-dependent kinase-like five) gene. CDKL5 disorder…”
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13
Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death
Published in Aging and disease (01-06-2021)“…CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disease caused by mutations in the X-linked gene. Children affected by CDD display a clinical…”
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14
Multiple sleep alterations in mice lacking cannabinoid type 1 receptors
Published in PloS one (20-02-2014)“…Cannabinoid type 1 (CB1) receptors are highly expressed in the brain and play a role in behavior control. Endogenous cannabinoid signaling is modulated by…”
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15
SCOPRISM: A new algorithm for automatic sleep scoring in mice
Published in Journal of neuroscience methods (30-09-2014)“…•We tested a new open-source sleep-scoring algorithm (SCOPRISM) on 92 mice.•We successfully validated SCOPRISM in wild-type mice and mouse models of obesity…”
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16
Validation of 'Somnivore', a Machine Learning Algorithm for Automated Scoring and Analysis of Polysomnography Data
Published in Frontiers in neuroscience (18-03-2019)“…Manual scoring of polysomnography data is labor-intensive and time-consuming, and most existing software does not account for subjective differences and user…”
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17
Orexin/Hypocretin and Histamine Cross-Talk on Hypothalamic Neuron Counts in Mice
Published in Frontiers in neuroscience (20-05-2021)“…The loss of hypothalamic neurons that produce wake-promoting orexin (hypocretin) neuropeptides is responsible for narcolepsy type 1 (NT1). While the number of…”
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18
Sleep related changes in blood pressure in hypocretin-deficient narcoleptic mice
Published in Sleep (New York, N.Y.) (01-02-2011)“…Although blood pressure during sleep and the difference in blood pressure between sleep and wakefulness carry prognostic information, little is known on their…”
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19
Author Correction: Neural control of fasting-induced torpor in mice
Published in Scientific reports (03-03-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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20
Cardiorespiratory anomalies in mice lacking CB1 cannabinoid receptors
Published in PloS one (20-06-2014)“…Cannabinoid type 1 (CB1) receptors are expressed in the nervous and cardiovascular systems. In mice, CB1 receptor deficiency protects from metabolic…”
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