Search Results - "Zlotnick, A"

Complete Blockage of HBV Virus Replication and Inhibition of cccDNA Formation by Core Protein Allosteric Modifiers by Li, P.-C, Connelly, E, Zong, Y, Zhou, Y, Sun, S, Zlotnick, A, Arnold, L, Lopatin, U, Huang, Q

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Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy by Conway, J. F, Cheng, N, Zlotnick, A, Wingfield, P. T, Stahl, S. J, Steven, A. C

“…Despite the development of vaccines, the hepatitis B virus remains a major cause of human liver disease. The virion consists of a lipoprotein envelope…”
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Anti capsid drugs HAP12 and AT130 target HBV core protein nuclear functions by Belloni, L, Palumbo, G.A, Li, L, Chirapu, S.R, Calvo, L, Lupacchini, L, Finn, M.G, Lopatin, U, Zlotnick, A, Levrero, M

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P0529 : Anti capsid drugs HAP12 and AT130 target HBV core protein nuclear functions by Belloni, L, Palumbo, G.A, Lupacchini, L, Li, L, Reddy Chirapu, S, Calvo, L, Finn, M.G, Lopatin, U, Zlotnick, A, Levrero, M

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Preclinical Characterization of Potent Core Protein Assembly Modulators for the Treatment of Chronic Hepatitis B by Huang, Q, Mercier, A, Zhou, Y, Henne, K, Kumar, G. Renuka, Sun, S, Guo, L, Liu, J, Zong, Y, Sun, T, Nabel, K, Li, P.-C, Mahon, C, Chen, G, Bures, M, Li, L, May, E, Connelly, E, Deer, J, Katen, S, Francis, S, Turner, W.W, Zlotnick, A, Arnold, L.D, Lopatin, U

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371 HAPS HEPATITIS B VIRUS (HBV) CAPSID INHIBITORS AFFECT CORE PROTEIN INTERACTION WITH THE MINICHROMOSOME AND TARGET cccDNA FUNCTION by Belloni, L, Li, L, Palumbo, G.A, Chirapu, S.R, Calvo, L, Finn, M, Zlotnick, A, Levrero, M

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736 NOVEL EFFECTOR OF HBV CAPSID ASSEMBLY REDUCES THE ACTIVITY OF cccDNA AND INTERACTS SYNERGISTICALLY WITH NUCLEOSIDE ANALOGS IN THE HUMAN HEPATOCYTES by Bassit, L, Ozturk, T, Tao, S, Boucle, S.R, Ehteshami, M, Zlotnick, A, Feitelson, M.A, Schinazi, R.F

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HAPs hepatitis B virus (HBV) capsid inhibitors prevent HBc interaction with the viral minichromosome and selected host cell genes to inhibits transcription and affect cccDNA stability by Belloni, L, Li, L, Palumbo, G.A, Chirapu, S.R, Calvo, L, Finn, M.G, Lopatin, U, Zlotnick, A, Levrero, M

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Localization of the C Terminus of the Assembly Domain of Hepatitis B Virus Capsid Protein: Implications for Morphogenesis and Organization of Encapsidated RNA by Zlotnick, A., Cheng, N., Stahl, S. J., Conway, J. F., Steven, A. C., Wingfield, P. T.

“…The capsid protein of hepatitis B virus, consisting of an ``assembly'' domain (residues 1-149) and an RNA-binding ``protamine'' domain (residues 150-183),…”
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Dimorphism of Hepatitis B Virus Capsids Is Strongly Influenced by the C-Terminus of the Capsid Protein by Zlotnick, A, Cheng, N, Conway, J. F, Booy, F. P, Steven, A. C, Stahl, S. J, Wingfield, P. T

“…Hepatitis B virus (HBV) is an enveloped virus with an icosahedral capsid. Its homodimeric capsid protein (“core antigen”) assembles into particles of two…”
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T-18 The HBV capsid inhibitors HAPs affect core protein interaction with the minichromosome and target cccDNA function by Belloni, L, Li, L, Palumbo, G.A, Chirapu, S.R, Calvo, L, Finn, M.G, Zlotnick, A, Levrero, M

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Accuracy of three‐dimensionally printed animal‐specific drill guides for implant placement in canine thoracic vertebrae: A cadaveric study by Mariani, Christopher L., Zlotnick, Joshua A., Harrysson, Ola, Marcellin‐Little, Denis J., Malinak, Kristen, Gavitt, Ashley, Guevar, Julien

“…Objective To assess the accuracy of three‐dimensionally (3‐D) printed drill guides in constraining the trajectory of drill tracts for implants in canine…”
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Are weak protein–protein interactions the general rule in capsid assembly? by Zlotnick, Adam

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Effects of the Cowpea chlorotic mottle bromovirus β-hexamer structure on virion assembly by Willits, D, Zhao, X, Olson, N, Baker, T.S, Zlotnick, A, Johnson, J.E, Douglas, T, Young, M.J

“…The X-ray crystal structure of Cowpea chlorotic mottle bromovirus (CCMV) revealed a unique tubular structure formed by the interaction of the N-termini from…”
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Distinguishing Reversible from Irreversible Virus Capsid Assembly by Zlotnick, Adam

“…Capsids of spherical viruses may be constructed from hundreds or thousands of copies of the major capsid protein(s). These assembly reactions are poorly…”
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Hepatitis B virus capsid: localization of the putative immunodominant loop (residues 78 to 83) on the capsid surface, and implications for the distinction between c and e-antigens by Conway, J.F, Cheng, N, Zlotnick, A, Stahl, S.J, Wingfield, P.T, Belnap, D.M, Kanngiesser, U, Noah, M, Steven, A.C

“…Hepatitis B virus capsid protein comprises a 149 residue “assembly” domain that polymerizes into icosahedral particles, and a 34 residue RNA-binding…”
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Localization of the N Terminus of Hepatitis B Virus Capsid Protein by Peptide-Based difference Mapping from Cryoelectron Microscopy by Conway, J. F., Cheng, N., Zlotnick, A., Stahl, S. J., Wingfield, P. T., Steven, A. C.

“…Recently, cryoelectron microscopy of isolated macromolecular complexes has advanced to resolutions below 10 angstrom, enabling direct visualization of α…”
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Capsid assembly in a family of animal viruses primes an autoproteolytic maturation that depends on a single aspartic acid residue by Zlotnick, A, Reddy, V.S, Dasgupta, R, Schneemann, A, Ray, W.J. Jr, Rueckert, R.R, Johnson, J.E

“…Maturation of noninfectious nodavirus provirions occurs by autoproteolytic cleavage of most of the 180 copies of the alpha-protein that make up the icosahedral…”
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Serum levels of IL‐1, IL‐6 and tumour necrosis factors in patients undergoing coronary artery bypass grafts or cholecystectomy by LAHAT, N, ZLOTNICK, A. Y., SHTILLER, R., BAR, I., MERIN, G.

“…SUMMARY Plasma levels of biologically active IL‐1, tumour necrosis factor (TNF) and IL‐6 were measured before, during and after coronary artery bypass…”
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Theoretical aspects of virus capsid assembly by Zlotnick, Adam

“…A virus capsid is constructed from many copies of the same protein(s). Molecular recognition is central to capsid assembly. The capsid protein must polymerize…”
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