Search Results - "Zloh, Mire"

An analysis of the ‘legal high’ mephedrone by Gibbons, Simon, Zloh, Mire

“…Analysis of a sample of the methyl-cathinone derivative mephedrone (1) has led to the full unambiguous assignment of the spectral data for this compound…”
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Deep Learning for Novel Antimicrobial Peptide Design by Wang, Christina, Garlick, Sam, Zloh, Mire

“…Antimicrobial resistance is an increasing issue in healthcare as the overuse of antibacterial agents rises during the COVID-19 pandemic. The need for new…”
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Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken by Bhutto, Zohaib Ahmed, He, Fang, Zloh, Mire, Yang, Jing, Huang, Jinhu, Guo, Tingting, Wang, Liping

“…Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to…”
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Design and Synthesis of Pyridyl and 2-Hydroxyphenyl Chalcones with Antitubercular Activity by Aziafor, Kelphina, Ruparelia, Ketan, Moulds, Brandon, Zloh, Mire, Parish, Tanya, Brucoli, Federico

“…A focussed library of pyridyl and 2-hydroxyphenyl chalcones were synthesized and tested for growth inhibitory activity against H37Rv, and normal and cancer…”
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Evaluation of Encapsulation Potential of Selected Star-Hyperbranched Polyglycidol Architectures: Predictive Molecular Dynamics Simulations and Experimental Validation by Gosecki, Mateusz, Urbaniak, Malgorzata, Martinho, Nuno, Gosecka, Monika, Zloh, Mire

“…Polymers, including non-linear copolymers, have great potential in the development of drug delivery systems with many advantages, but the design requires…”
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Molecular Modeling to Study Dendrimers for Biomedical Applications by Martinho, Nuno, Florindo, Helena, Silva, Liana, Brocchini, Steve, Zloh, Mire, Barata, Teresa

“…Molecular modeling techniques provide a powerful tool to study the properties of molecules and their interactions at the molecular level. The use of…”
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Inhibitory Effect of Berberine on Broiler P-glycoprotein Expression and Function: In Situ and In Vitro Studies by Zhang, Yujuan, Guo, Li, Huang, Jinhu, Sun, Yong, He, Fang, Zloh, Mire, Wang, Liping

“…Overcoming P-glycoprotein (P-gp) efflux is a strategy to improve the absorption and pharmacokinetics of its substrate drugs. Berberine inhibits P-gp and…”
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Flavonoids from Artemisia rupestris and their synergistic antibacterial effects on drug-resistant Staphylococcus aureus by Lan, Jiang-Er, Li, Xiao-Jin, Zhu, Xiao-Feng, Sun, Zhong-Lin, He, Jian-Ming, Zloh, Mire, Gibbons, Simon, Mu, Qing

“…This study seeks to discover flavonoids from a traditional Chinese herb, Artemisia rupestris L., with synergistic antibacterial effects against…”
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Synthesis and in Silico Modelling of the Potential Dual Mechanistic Activity of Small Cationic Peptides Potentiating the Antibiotic Novobiocin against Susceptible and Multi-Drug Resistant Escherichia coli by Passarini, Ilaria, Resende, Pedro Ernesto de, Soares, Sarah, Tahmasi, Tadeh, Stapleton, Paul, Malkinson, John, Zloh, Mire, Rossiter, Sharon

“…Cationic antimicrobial peptides have attracted interest, both as antimicrobial agents and for their ability to increase cell permeability to potentiate other…”
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3D-QSAR study of adenosine 5’-phosphosulfate (APS) analouges as ligands for APS reductase by Eric, Slavica, Cvijetic, Ilija, Zloh, Mire

“…Metabolism of sulfur (sulfur assimilation pathway, SAP) is one of the key pathways for the pathogenesis and survival of persistant bacteria, such as…”
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Crystal Structure of a Promoter Sequence in the B‑raf Gene Reveals an Intertwined Dimer Quadruplex by Wei, Dengguo, Todd, Alan K, Zloh, Mire, Gunaratnam, Mekala, Parkinson, Gary N, Neidle, Stephen

“…The sequence d­(GGG­CGG­GGA­GGG­GGAA­GGGA) occurs in the promoter region of the B-raf gene. An X-ray crystallographic study has found that this forms an…”
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Relevance of Breast Cancer Resistance Protein to Pharmacokinetics of Florfenicol in Chickens: A Perspective from In Vivo and In Vitro Studies by Liu, Yang, Guo, Li, Zloh, Mire, Zhang, Yujuan, Huang, Jinhu, Wang, Liping

“…Florfenicol (FFC) is a valuable synthetic fluorinated derivative of thiamphenicol widely used to treat infectious diseases in food animals. The aims of the…”
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Early detection of metabolic changes in drug-induced steatosis using metabolomics approaches by Yong, Helena Y, Larrouy-Maumus, Gerald, Zloh, Mire, Smyth, Rosemary, Ataya, Rayan, Benton, Christopher M, Munday, Michael R

“…Steatosis is the accumulation of triglycerides in hepatic cells wherein fats exceed 5% of the entire liver weight. Although steatotic liver damage is…”
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Detection of newly emerging psychoactive substances using Raman spectroscopy and chemometrics by Calvo-Castro, Jesus, Guirguis, Amira, Samaras, Eleftherios G, Zloh, Mire, Kirton, Stewart B, Stair, Jacqueline L

“…A novel approach for the identification of New Psychoactive Substances (NPS) by means of Raman spectroscopy coupled with Principal Components Analysis (PCA)…”
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In Silico Structural Evaluation of Short Cationic Antimicrobial Peptides by Passarini, Ilaria, Rossiter, Sharon, Malkinson, John, Zloh, Mire

“…Cationic peptides with antimicrobial properties are ubiquitous in nature and have been studied for many years in an attempt to design novel antibiotics…”
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DFT study of the radical scavenging activity of isoxanthohumol, humulones (α-acids), and iso-α-acids from beer by Cvijetić, Ilija, Bigović, Miljan, Ristivojević, Petar, Vitorović-Todorović, Maja, Zloh, Mire, Milojković-Opsenica, Dušanka

“…Humulones and iso-humulones are potent natural antioxidants found in beer. In this study, density functional theory (DFT) method was applied for elucidating…”
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Site-specific PEGylation of native disulfide bonds in therapeutic proteins by Shaunak, Sunil, Brocchini, Steve, Godwin, Antony, Choi, Ji-Won, Balan, Sibu, Pedone, Elisa, Vijayarangam, Damotharan, Heidelberger, Sibylle, Teo, Ian, Zloh, Mire

“…Native disulfide bonds in therapeutic proteins are crucial for tertiary structure and biological activity and are therefore considered unsuitable for chemical…”
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Drowning in diversity? A systematic way of clustering and selecting a representative set of new psychoactive substances by Zloh, Mire, Samaras, Eleftherios G., Calvo-Castro, Jesus, Guirguis, Amira, Stair, Jacqueline L., Kirton, Stewart B.

“…New psychoactive substances (NPS) can be generally described as a set of compounds that have been designed to mimic the effects of illegal recreational drugs,…”
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Identification of Protein-Excipient Interaction Hotspots Using Computational Approaches by Barata, Teresa S, Zhang, Cheng, Dalby, Paul A, Brocchini, Steve, Zloh, Mire

“…Protein formulation development relies on the selection of excipients that inhibit protein-protein interactions preventing aggregation. Empirical strategies…”
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VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins by Eldrid, Charles, Zloh, Mire, Fotinou, Constantina, Yelland, Tamas, Yu, Lefan, Mota, Filipa, Selwood, David L, Djordjevic, Snezana

“…Vascular endothelial growth factors (VEGFs) are the key regulators of blood and lymphatic vessels' formation and function. Each of the proteins from the…”
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