Search Results - "Zlatanou, Anastasia"

Mechanisms of Post-Replication DNA Repair by Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Zlatanou, Anastasia, Vaziri, Cyrus, Yang, Yang

“…Accurate DNA replication is crucial for cell survival and the maintenance of genome stability. Cells have developed mechanisms to cope with the frequent…”
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The Protein Kinase CK2 Facilitates Repair of Chromosomal DNA Single-Strand Breaks by Loizou, Joanna I., El-Khamisy, Sherif F., Zlatanou, Anastasia, Moore, David J., Chan, Douglas W., Qin, Jun, Sarno, Stefania, Meggio, Flavio, Pinna, Lorenzo A., Caldecott, Keith W.

“…CK2 was the first protein kinase identified and is required for the proliferation and survival of mammalian cells. Here, we have identified an unanticipated…”
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Ubiquitin-dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination by Tikoo, Shweta, Madhavan, Vinoth, Hussain, Mansoor, Miller, Edward S, Arora, Prateek, Zlatanou, Anastasia, Modi, Priyanka, Townsend, Kelly, Stewart, Grant S, Sengupta, Sagar

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DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress by Yang, Yang, Gao, Yanzhe, Mutter-Rottmayer, Liz, Zlatanou, Anastasia, Durando, Michael, Ding, Weimin, Wyatt, David, Ramsden, Dale, Tanoue, Yuki, Tateishi, Satoshi, Vaziri, Cyrus

“…The mechanisms by which neoplastic cells tolerate oncogene-induced DNA replication stress are poorly understood. Cyclin-dependent kinase 2 (CDK2) is a major…”
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Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis by Yang, Yang, Gao, Yanzhe, Zlatanou, Anastasia, Tateishi, Satoshi, Yurchenko, Vyacheslav, Rogozin, Igor B., Vaziri, Cyrus

“…Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the 'Y-family' Trans-Lesion…”
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BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks by Higgs, Martin R., Reynolds, John J., Winczura, Alicja, Blackford, Andrew N., Borel, Valérie, Miller, Edward S., Zlatanou, Anastasia, Nieminuszczy, Jadwiga, Ryan, Ellis L., Davies, Nicholas J., Stankovic, Tatjana, Boulton, Simon J., Niedzwiedz, Wojciech, Stewart, Grant S.

“…Recognition and repair of damaged replication forks are essential to maintain genome stability and are coordinated by the combined action of the Fanconi anemia…”
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USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status by Agathanggelou, Angelo, Smith, Edward, Davies, Nicholas J., Kwok, Marwan, Zlatanou, Anastasia, Oldreive, Ceri E., Mao, Jingwen, Da Costa, David, Yadollahi, Sina, Perry, Tracey, Kearns, Pamela, Skowronska, Anna, Yates, Elliot, Parry, Helen, Hillmen, Peter, Reverdy, Celine, Delansorne, Remi, Paneesha, Shankara, Pratt, Guy, Moss, Paul, Taylor, A.Malcolm R., Stewart, Grant S., Stankovic, Tatjana

“…The role of deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation of the p53-dependent DNA damage response (DDR) pathway is well established…”
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Acylpeptide hydrolase is a component of the cellular response to DNA damage by Zeng, Zhihong, Rulten, Stuart L., Breslin, Claire, Zlatanou, Anastasia, Coulthard, Victoria, Caldecott, Keith W.

“…•The cytosolic protease (APEH) is a component of the mammalian DNA damage response.•APEH interacts directly with XRCC1, a critical nuclear scaffold protein…”
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Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism by Reynolds, John J, Bicknell, Louise S, Carroll, Paula, Higgs, Martin R, Shaheen, Ranad, Murray, Jennie E, Papadopoulos, Dimitrios K, Leitch, Andrea, Murina, Olga, Tarnauskaitė, Žygimantė, Wessel, Sarah R, Zlatanou, Anastasia, Vernet, Audrey, von Kriegsheim, Alex, Mottram, Rachel M A, Logan, Clare V, Bye, Hannah, Li, Yun, Brean, Alexander, Maddirevula, Sateesh, Challis, Rachel C, Skouloudaki, Kassiani, Almoisheer, Agaadir, Alsaif, Hessa S, Amar, Ariella, Prescott, Natalie J, Bober, Michael B, Duker, Angela, Faqeih, Eissa, Seidahmed, Mohammed Zain, Al Tala, Saeed, Alswaid, Abdulrahman, Ahmed, Saleem, Al-Aama, Jumana Yousuf, Altmüller, Janine, Al Balwi, Mohammed, Brady, Angela F, Chessa, Luciana, Cox, Helen, Fischetto, Rita, Heller, Raoul, Henderson, Bertram D, Hobson, Emma, Nürnberg, Peter, Percin, E Ferda, Peron, Angela, Spaccini, Luigina, Quigley, Alan J, Thakur, Seema, Wise, Carol A, Yoon, Grace, Alnemer, Maha, Tomancak, Pavel, Yigit, Gökhan, Taylor, A Malcolm R, Reijns, Martin A M, Simpson, Michael A, Cortez, David, Alkuraya, Fowzan S, Mathew, Christopher G, Jackson, Andrew P, Stewart, Grant S

“…Grant Stewart, Andrew Jackson, Christopher Mathew, Fowzan Alkuraya and colleagues identify a novel replication fork protein, DONSON, which is important for…”
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The hMsh2-hMsh6 Complex Acts in Concert with Monoubiquitinated PCNA and Pol η in Response to Oxidative DNA Damage in Human Cells by Zlatanou, Anastasia, Despras, Emmanuelle, Braz-Petta, Tirzah, Boubakour-Azzouz, Imenne, Pouvelle, Caroline, Stewart, Grant S., Nakajima, Satoshi, Yasui, Akira, Ishchenko, Alexander A., Kannouche, Patricia L.

“…Posttranslational modification of PCNA by ubiquitin plays an important role in coordinating the processes of DNA damage tolerance during DNA replication. The…”
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Ubiquitin‐dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination by Tikoo, Shweta, Madhavan, Vinoth, Hussain, Mansoor, Miller, Edward S, Arora, Prateek, Zlatanou, Anastasia, Modi, Priyanka, Townsend, Kelly, Stewart, Grant S, Sengupta, Sagar

“…Limiting the levels of homologous recombination (HR) that occur at sites of DNA damage is a major role of BLM helicase. However, very little is known about the…”
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TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism by Harley, Margaret E, Murina, Olga, Leitch, Andrea, Higgs, Martin R, Bicknell, Louise S, Yigit, Gökhan, Blackford, Andrew N, Zlatanou, Anastasia, Mackenzie, Karen J, Reddy, Kaalak, Halachev, Mihail, McGlasson, Sarah, Reijns, Martin A M, Fluteau, Adeline, Martin, Carol-Anne, Sabbioneda, Simone, Elcioglu, Nursel H, Altmüller, Janine, Thiele, Holger, Greenhalgh, Lynn, Chessa, Luciana, Maghnie, Mohamad, Salim, Mahmoud, Bober, Michael B, Nürnberg, Peter, Jackson, Stephen P, Hurles, Matthew E, Wollnik, Bernd, Stewart, Grant S, Jackson, Andrew P

“…Andrew Jackson, Grant Stewart, Bernd Wollnik and colleagues identify TRAIP mutations in three patients with primordial dwarfism. They show that TRAIP is…”
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Human DNA polymerase iota protects cells against oxidative stress by Petta, Tirzah Braz, Nakajima, Satoshi, Zlatanou, Anastasia, Despras, Emmanuelle, Couve-Privat, Sophie, Ishchenko, Alexander, Sarasin, Alain, Yasui, Akira, Kannouche, Patricia

“…Human DNA polymerase iota (polι) is a unique member of the Y‐family of specialised polymerases that displays a 5′deoxyribose phosphate (dRP) lyase activity…”
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Damaged replication forks tolerate USP7 to maintain genome stability by Zlatanou, Anastasia, Stewart, Grant S.

“…RAD18 functions to promote DNA damage tolerance (DTT), a process that ensures faithful genome duplication. Protein ubiquitylation/deubiquitylation is a…”
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New Therapeutic Strategy for Sensitisation of CLL Cells with Inactivation of the DNA Damage Response by Targeting the Deubiquitylating Enzyme USP7-Dependent Pathways by Agathanggelou, Angelo, Zlatanou, Anastasia, Gulshanara, Ahmed, Stewart, Grant, Kearns, Pamela R, Pratt, Guy, Moss, Paul AH, Taylor, A. Malcolm R, Colland, Frederic, Stankovic, Tatjana

“…Abstract 3865 Chronic Lymphocytic Leukaemia (CLL) is characterised by marked clinical heterogeneity and tumours with deletion or mutation of the TP53 and ATM…”
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The hMsh2-hMsh6 Complex Acts in Concert with Monoubiquitinated PCNA and Pol [eta] in Response to Oxidative DNA Damage in Human Cells by Zlatanou, Anastasia, Despras, Emmanuelle, Braz-Petta, Tirzah, Boubakour-Azzouz, Imenne, Pouvelle, Caroline, Stewart, Grant S, Nakajima, Satoshi, Yasui, Akira, Ishchenko, Alexander A, Kannouche, Patricia L

“…Posttranslational modification of PCNA by ubiquitin plays an important role in coordinating the processes of DNA damage tolerance during DNA replication. The…”
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A PIAS-ed view of DNA double strand break repair focuses on SUMO by Zlatanou, Anastasia, Stewart, Grant S.

“…Through the action of multiple sensors, mediators, and effectors, the DNA damage response (DDR) orchestrates the repair of DNA damage to ensure maintenance of…”
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Analysis of XRCC1 Protein Complexes and Oxidized Protein Hydrolase as a Novel XRCC1 Partner by Zlatanou, Anastasia

“…The repair of DNA damage involves the sequestration and coordination of a number of protein complexes to sites of DNA damage which act in a concerted fashion…”
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