Search Results - "Zlabinger, Katrin"

Preclinical development of a miR-132 inhibitor for heart failure treatment by Foinquinos, Ariana, Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Gyöngyösi, Mariann, Traxler, Denise, Riesenhuber, Martin, Spannbauer, Andreas, Lukovic, Dominika, Weber, Natalie, Zlabinger, Katrin, Hašimbegović, Ena, Winkler, Johannes, Fiedler, Jan, Dangwal, Seema, Fischer, Martin, de la Roche, Jeanne, Wojciechowski, Daniel, Kraft, Theresia, Garamvölgyi, Rita, Neitzel, Sonja, Chatterjee, Shambhabi, Yin, Xiaoke, Bär, Christian, Mayr, Manuel, Xiao, Ke, Thum, Thomas

“…Despite proven efficacy of pharmacotherapies targeting primarily global neurohormonal dysregulation, heart failure (HF) is a growing pandemic with increasing…”
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Identification of Gene Expression Signatures for Phenotype-Specific Drug Targeting of Cardiac Fibrosis by Lukovic, Dominika, Hasimbegovic, Ena, Winkler, Johannes, Mester-Tonczar, Julia, Müller-Zlabinger, Katrin, Han, Emilie, Spannbauer, Andreas, Traxler-Weidenauer, Denise, Bergler-Klein, Jutta, Pavo, Noemi, Goliasch, Georg, Batkai, Sandor, Thum, Thomas, Zannad, Faiez, Gyöngyösi, Mariann

“…We have designed translational animal models to investigate cardiac profibrotic gene signatures. Domestic pigs were treated with cardiotoxic drugs…”
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Plasma Small Extracellular Vesicle Cardiac miRNA Expression in Patients with Ischemic Heart Failure, Randomized to Percutaneous Intramyocardial Treatment of Adipose Derived Stem Cells or Placebo: Subanalysis of the SCIENCE Study by Traxler, Denise, Dannenberg, Varius, Zlabinger, Katrin, Gugerell, Alfred, Mester-Tonczar, Julia, Lukovic, Dominika, Spannbauer, Andreas, Hasimbegovic, Ena, Kastrup, Jens, Gyöngyösi, Mariann

“…Small extracellular vesicles (EVs) and their cargo are an important component of cell-to-cell communication in cardiac disease. Allogeneic adipose derived stem…”
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Effect of Ischemic Preconditioning and Postconditioning on Exosome-Rich Fraction microRNA Levels, in Relation with Electrophysiological Parameters and Ventricular Arrhythmia in Experimental Closed-Chest Reperfused Myocardial Infarction by Spannbauer, Andreas, Traxler, Denise, Lukovic, Dominika, Zlabinger, Katrin, Winkler, Johannes, Gugerell, Alfred, Ferdinandy, Péter, Hausenloy, Derek J, Pavo, Noemi, Emmert, Maximilian Y, Hoerstrup, Simon P, Jakab, Andras, Gyöngyösi, Mariann, Riesenhuber, Martin

“…We investigated the antiarrhythmic effects of ischemic preconditioning (IPC) and postconditioning (PostC) by intracardiac electrocardiogram (ECG) and measured…”
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A CircRNA-miRNA-mRNA Network for Exploring Doxorubicin- and Myocet-Induced Cardiotoxicity in a Translational Porcine Model by Mester-Tonczar, Julia, Einzinger, Patrick, Hasimbegovic, Ena, Kastner, Nina, Schweiger, Victor, Spannbauer, Andreas, Han, Emilie, Müller-Zlabinger, Katrin, Traxler-Weidenauer, Denise, Bergler-Klein, Jutta, Gyöngyösi, Mariann, Lukovic, Dominika

“…Despite the widespread use of doxorubicin (DOX) as a chemotherapeutic agent, its severe cumulative cardiotoxicity represents a significant limitation. While…”
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Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro by Mester-Tonczar, Julia, Einzinger, Patrick, Winkler, Johannes, Kastner, Nina, Spannbauer, Andreas, Zlabinger, Katrin, Traxler, Denise, Lukovic, Dominika, Hasimbegovic, Ena, Goliasch, Georg, Pavo, Noemi, Gyöngyösi, Mariann

“…Circular RNAs (circRNAs) are crucial in gene regulatory networks and disease development, yet circRNA expression in myocardial infarction (MI) is poorly…”
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Association between Circular RNA CDR1as and Post-Infarction Cardiac Function in Pig Ischemic Heart Failure: Influence of the Anti-Fibrotic Natural Compounds Bufalin and Lycorine by Mester-Tonczar, Julia, Winkler, Johannes, Einzinger, Patrick, Hasimbegovic, Ena, Kastner, Nina, Lukovic, Dominika, Zlabinger, Katrin, Spannbauer, Andreas, Traxler, Denise, Batkai, Sandor, Thum, Thomas, Gyöngyösi, Mariann

“…Anti-fibrotic therapies are of increasing interest to combat cardiac remodeling and heart failure progression. Recently, anti-fibrotic circular RNAs (circRNAs)…”
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Circular RNAs in Cardiac Regeneration: Cardiac Cell Proliferation, Differentiation, Survival, and Reprogramming by Mester-Tonczar, Julia, Hašimbegović, Ena, Spannbauer, Andreas, Traxler, Denise, Kastner, Nina, Zlabinger, Katrin, Einzinger, Patrick, Pavo, Noemi, Goliasch, Georg, Gyöngyösi, Mariann

“…Circular RNAs (circRNAs) are classified as long non-coding RNAs (lncRNAs) that are characterized by a covalent closed-loop structure. This closed-loop shape is…”
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New Insights and Current Approaches in Cardiac Hypertrophy Cell Culture, Tissue Engineering Models, and Novel Pathways Involving Non-Coding RNA by Kastner, Nina, Zlabinger, Katrin, Spannbauer, Andreas, Traxler, Denise, Mester-Tonczar, Julia, Hašimbegović, Ena, Gyöngyösi, Mariann

“…Cardiac hypertrophy is an ongoing clinical challenge, as risk factors such as obesity, smoking and increasing age become more widespread, which lead to an…”
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Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension by Gyöngyösi, Mariann, Pavo, Noemi, Lukovic, Dominika, Zlabinger, Katrin, Spannbauer, Andreas, Traxler, Denise, Goliasch, Georg, Mandic, Ljubica, Bergler-Klein, Jutta, Gugerell, Alfred, Jakab, Andras, Szankai, Zsuzsanna, Toth, Levente, Garamvölgyi, Rita, Maurer, Gerald, Jaisser, Frederic, Zannad, Faiez, Thum, Thomas, Bátkai, Sándor, Winkler, Johannes

“…Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic…”
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Large Animal Models of Heart Failure With Reduced Ejection Fraction (HFrEF) by Spannbauer, Andreas, Traxler, Denise, Zlabinger, Katrin, Gugerell, Alfred, Winkler, Johannes, Mester-Tonczar, Julia, Lukovic, Dominika, Müller, Claudia, Riesenhuber, Martin, Pavo, Noemi, Gyöngyösi, Mariann

“…Heart failure with reduced ejection fraction (HFrEF) is defined by an ejection fraction (EF) below 40%. Many distinct disease processes culminate in HFrEF,…”
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Early Elevation of Systemic Plasma Clusterin after Reperfused Acute Myocardial Infarction in a Preclinical Porcine Model of Ischemic Heart Disease by Traxler, Denise, Spannbauer, Andreas, Einzinger, Patrick, Mester-Tonczar, Julia, Lukovic, Dominika, Winkler, Johannes, Zlabinger, Katrin, Gugerell, Alfred, Mandic, LJubica, Gyöngyösi, Mariann, Pavo, Noemi

“…Clusterin exerts anti-inflammatory, cytoprotective and anti-apoptotic effects. Both an increase and decrease of clusterin in acute myocardial infarction (AMI)…”
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Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling by Pavo, Noemi, Lukovic, Dominika, Zlabinger, Katrin, Zimba, Abelina, Lorant, David, Goliasch, Georg, Winkler, Johannes, Pils, Dietmar, Auer, Katharina, Jan Ankersmit, Hendrik, Giricz, Zoltán, Baranyai, Tamas, Sárközy, Márta, Jakab, András, Garamvölgyi, Rita, Emmert, Maximilian Y., Hoerstrup, Simon P., Hausenloy, Derek J., Ferdinandy, Péter, Maurer, Gerald, Gyöngyösi, Mariann

“…We have analyzed the pathway networks of ischemia-affected and remote myocardial areas after repetitive ischemia/reperfusion (r-I/R) injury without ensuing…”
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Improvement of Symptoms and Cardiac Magnetic Resonance Abnormalities in Patients with Post-Acute Sequelae of SARS-CoV-2 Cardiovascular Syndrome (PASC-CVS) after Guideline-Oriented Therapy by Gyöngyösi, Mariann, Hasimbegovic, Ena, Han, Emilie, Zlabinger, Katrin, Spannbauer, Andreas, Riesenhuber, Martin, Hamzaraj, Kevin, Bergler-Klein, Jutta, Hengstenberg, Christian, Kammerlander, Andreas, Kastl, Stefan, Loewe, Christian, Beitzke, Dietrich

“…Cardiac magnetic resonance (CMR) studies reported CMR abnormalities in patients with mild-moderate SARS-CoV-2 infection, suggesting ongoing myocardial…”
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Transcriptional Alterations by Ischaemic Postconditioning in a Pig Infarction Model: Impact on Microvascular Protection by Lukovic, Dominika, Gugerell, Alfred, Zlabinger, Katrin, Winkler, Johannes, Pavo, Noemi, Baranyai, Tamás, Giricz, Zoltán, Varga, Zoltán V, Riesenhuber, Martin, Spannbauer, Andreas, Traxler, Denise, Jakab, András, Garamvölgyi, Rita, Petnehazy, Örs, Pils, Dietmar, Tóth, Levente, Schulz, Rainer, Ferdinandy, Péter, Gyöngyösi, Mariann

“…Although the application of cardioprotective ischaemia/reperfusion (I/R) stimuli after myocardial infarction (MI) is a promising concept for salvaging the…”
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Large Animal Models of Cell-Free Cardiac Regeneration by Spannbauer, Andreas, Mester-Tonczar, Julia, Traxler, Denise, Kastner, Nina, Zlabinger, Katrin, Hašimbegović, Ena, Riesenhuber, Martin, Pavo, Noemi, Goliasch, Georg, Gyöngyösi, Mariann

“…The adult mammalian heart lacks the ability to sufficiently regenerate itself, leading to the progressive deterioration of function and heart failure after…”
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Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome by Gyöngyösi, Mariann, Lukovic, Dominika, Mester-Tonczar, Julia, Zlabinger, Katrin, Einzinger, Patrick, Spannbauer, Andreas, Schweiger, Victor, Schefberger, Katharina, Samaha, Eslam, Bergler-Klein, Jutta, Riesenhuber, Martin, Nitsche, Christian, Hengstenberg, Christian, Mucher, Patrick, Haslacher, Helmuth, Breuer, Monika, Strassl, Robert, Puchhammer-Stöckl, Elisabeth, Loewe, Christian, Beitzke, Dietrich, Hasimbegovic, Ena, Zelniker, Thomas A.

“…Epstein–Barr virus (EBV) reactivation may be involved in long-COVID symptoms, but reactivation of other viruses as a factor has received less attention. Here…”
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MiR-21, MiR-29a, GATA4, and MEF2c Expression Changes in Endothelin-1 and Angiotensin II Cardiac Hypertrophy Stimulated Isl-1 + Sca-1 + c-kit + Porcine Cardiac Progenitor Cells In Vitro by Zlabinger, Katrin, Spannbauer, Andreas, Traxler, Denise, Gugerell, Alfred, Lukovic, Dominika, Winkler, Johannes, Mester-Tonczar, Julia, Podesser, Bruno, Gyöngyösi, Mariann

“…Cost- and time-intensive porcine translational disease models offer great opportunities to test drugs and therapies for pathological cardiac hypertrophy and…”
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Cell-Based HIF1α Gene Therapy Reduces Myocardial Scar and Enhances Angiopoietic Proteome, Transcriptomic and miRNA Expression in Experimental Chronic Left Ventricular Dysfunction by Gara, Edit, Ong, Sang-Ging, Winkler, Johannes, Zlabinger, Katrin, Lukovic, Dominika, Merkely, Bela, Emmert, Maximilian Y, Wolint, Petra, Hoerstrup, Simon P, Gyöngyösi, Mariann, Wu, Joseph C, Pavo, Noemi

“…Recent preclinical investigations and clinical trials with stem cells mostly studied bone-marrow-derived mononuclear cells (BM-MNCs), which so far failed to…”
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Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived Cells by Winkler, Johannes, Lukovic, Dominika, Mester-Tonczar, Julia, Zlabinger, Katrin, Gugerell, Alfred, Pavo, Noemi, Jakab, András, Szankai, Zsuzsanna, Traxler, Denise, Müller, Claudia, Spannbauer, Andreas, Riesenhuber, Martin, Hašimbegović, Ena, Dawkins, James, Zimmermann, Matthias, Ankersmit, Hendrik J., Marbán, Eduardo, Gyöngyösi, Mariann

“…Cardiosphere-derived cells (CDCs) are progenitor cells derived from heart tissue and have shown promising results in preclinical models. APOSEC, the secretome…”
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