Search Results - "Ziyyat, Ahmed"
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Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility
Published in Science (American Association for the Advancement of Science) (08-01-2021)“…Posttranslational modifications of the microtubule cytoskeleton have emerged as key regulators of cellular functions, and their perturbations have been linked…”
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Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion
Published in Scientific reports (24-03-2020)“…Three genes are known to be essential for gamete adhesion/fusion ( Cd9, Izumo1 and Juno ). Here, we confirmed that Spaca6 null males are infertile and showed…”
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The cell biology of fertilization: Gamete attachment and fusion
Published in The Journal of cell biology (04-10-2021)“…Fertilization is defined as the union of two gametes. During fertilization, sperm and egg fuse to form a diploid zygote to initiate prenatal development. In…”
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Neurotensin and Its Involvement in Reproductive Functions: An Exhaustive Review of the Literature
Published in International journal of molecular sciences (27-02-2023)“…Neurotensin (NTS) is a peptide discovered in 1973, which has been studied in many fields and mainly in oncology for its action in tumor growth and…”
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5
H19 acts as a trans regulator of the imprinted gene network controlling growth in mice
Published in Development (Cambridge) (15-10-2009)“…The imprinted H19 gene produces a non-coding RNA of unknown function. Mice lacking H19 show an overgrowth phenotype, due to a cis effect of the H19 locus on…”
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Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization
Published in Development (Cambridge) (01-10-2014)“…Little is known about the molecular mechanisms that induce gamete fusion during mammalian fertilization. After initial contact, adhesion between gametes only…”
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Fertilization, but Not Post-Implantation Development, Can Occur in the Absence of Sperm and Oocyte Beta1 Integrin in Mice
Published in International journal of molecular sciences (09-11-2022)“…Fertilization is a complex process that requires successive stages and culminates in the adhesion/fusion of gamete membranes. If the question of the…”
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Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice
Published in International journal of molecular sciences (16-02-2021)“…Thanks to the analysis of an Interspecific Recombinant Congenic Strain (IRCS), we previously defined the quantitative trait locus as an interval on mouse…”
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The lack of Tex44 causes severe subfertility with flagellar abnormalities in male mice
Published in Cellular & molecular biology letters (15-05-2024)“…By analyzing a mouse Interspecific Recombinant Congenic Strain (IRCS), we previously identified a quantitative trait locus (QTL), called Mafq1 on mouse…”
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Tetraspanins and Mouse Oocyte Microvilli Related to Fertilizing Ability
Published in Reproductive sciences (Thousand Oaks, Calif.) (01-07-2017)“…Our electron microscopy observations demonstrate for the first time that the number of microvilli on the mice oocyte membrane decreases when meiosis progresses…”
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Partial Sperm beta1 Integrin Subunit Deletion Proves its Involvement in Mouse Gamete Adhesion/Fusion
Published in International journal of molecular sciences (11-11-2020)“…We have previously shown, using antibodies, that the sperm alpha6beta1 integrin is involved in mouse gamete fusion in vitro. Here we report the conditional…”
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CD9 tetraspanin generates fusion competent sites on the egg membrane for mammalian fertilization
Published in Proceedings of the National Academy of Sciences - PNAS (05-07-2011)“…CD9 tetraspanin is the only egg membrane protein known to be essential for fertilization. To investigate its role, we have measured, on a unique acrosome…”
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Cyclic FEE Peptide Improves Human Sperm Movement Parameters without Modification of Their Energy Metabolism
Published in International journal of molecular sciences (19-10-2021)“…Cyclic fertilin peptide (cFEE: phenylalanine, glutamic acid; glutamic acid) improves gamete interaction in humans. We investigate whether it could be via…”
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Cholesterol depletion disorganizes oocyte membrane rafts altering mouse fertilization
Published in PloS one (25-04-2013)“…Drastic membrane reorganization occurs when mammalian sperm binds to and fuses with the oocyte membrane. Two oocyte protein families are essential for…”
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Identification of a New QTL Region on Mouse Chromosome 1 Responsible for Male Hypofertility: Phenotype Characterization and Candidate Genes
Published in International journal of molecular sciences (12-11-2020)“…Male fertility disorders often have their origin in disturbed spermatogenesis, which can be induced by genetic factors. In this study, we used interspecific…”
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SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins
Published in Communications biology (17-09-2022)“…SPACA6 is a sperm-expressed surface protein that is critical for gamete fusion during mammalian sexual reproduction. Despite this fundamental role, little is…”
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Seminal leukocytes are Good Samaritans for spermatozoa
Published in Fertility and sterility (01-12-2011)“…Objective To assess the effect of leukocytospermia on assisted reproductive technology outcomes. Design Retrospective analysis. Setting University laboratory…”
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Refined mapping of a quantitative trait locus on chromosome 1 responsible for mouse embryonic death
Published in PloS one (16-08-2012)“…Recurrent spontaneous abortion (RSA) is defined as the loss of three or more consecutive pregnancies during the first trimester of embryonic intrauterine…”
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Paradoxical increase of sperm motility and seminal carnitine associated with moderate leukocytospermia in infertile patients
Published in Fertility and sterility (01-12-2008)“…Objective To examine the relationship between seminal polymorphonuclear (PMN) granulocytes and sperm functions (particularly sperm motility) in infertile men…”
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Alpha6beta1 integrin expressed by sperm is determinant in mouse fertilization
Published in BMC developmental biology (12-09-2007)“…Based on inhibition tests, the alpha6beta1 integrin was suggested to be a sperm receptor, but further experiments using gene deletion techniques have shown…”
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