Search Results - "Ziyadeh, Fuad N"

Cellular and molecular mechanisms of proteinuria in diabetic nephropathy by Wolf, Gunter, Ziyadeh, Fuad N

“…One of the earliest clinically detectable abnormalities in diabetic nephropathy is microalbuminuria that eventually progresses to proteinuria. The degree of…”
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Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells by Dagher, Oula K, Jaffa, Miran A, Habib, Aïda, Ziyadeh, Fuad N, Jaffa, Ayad A

“…Bradykinin (BK) and thromboxane-A2 (TX-A2) are two vasoactive mediators that modulate vascular tone and inflammation via binding to their cognate "class A"…”
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Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice by SUN HEE SUNG, ZIYADEH, Fuad N, WANG, Amy, PYAGAY, Petr E, KANWAR, Yashpal S, CHEN, Sheldon

“…For investigation of how the vascular endothelial growth factor (VEGF) system participates in the pathogenesis of diabetic kidney disease, type 2 diabetic…”
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The utility of the transtubular potassium gradient in the evaluation of hyperkalemia by Choi, Michael J, Ziyadeh, Fuad N

“…The transtubular potassium gradient (TTKG) is used to gauge renal potassium secretion by the cortical collecting duct, indirectly assessing mineralocorticoid…”
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Proteome profiling in the aorta and kidney of type 1 diabetic rats by Al Hariri, Moustafa, Elmedawar, Mohamad, Zhu, Rui, Jaffa, Miran A, Zhao, Jingfu, Mirzaei, Parvin, Ahmed, Adnan, Kobeissy, Firas, Ziyadeh, Fuad N, Mechref, Yehia, Jaffa, Ayad A

“…Diabetes is associated with a number of metabolic and cardiovascular risk factors that contribute to a high rate of microvascular and macrovascular…”
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20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway by Eid, Stephanie, Maalouf, Rita, Jaffa, Ayad A, Nassif, Joseph, Hamdy, Ahmed, Rashid, Awad, Ziyadeh, Fuad N, Eid, Assaad A

“…Diabetic nephropathy (DN), a major complication of diabetes, is characterized by hypertrophy, extracellular matrix accumulation, fibrosis and proteinuria…”
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Overview of the Physiology and Pathophysiology of Leptin With Special Emphasis on its Role in the Kidney by Nasrallah, Mona P., MD, Ziyadeh, Fuad N., MD

“…Summary The adipocyte product leptin is a pleiotropic adipokine and hormone, with a role extending beyond appetite suppression and increased energy…”
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The cardiorenal syndrome in diabetes mellitus by Karnib, Hussein H, Ziyadeh, Fuad N

“…Abstract The cardiorenal syndrome in patients with diabetes mellitus represents a systemic condition that affects both the cardiovascular and renal systems…”
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Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris by Jaffa, Aneese A., Jaffa, Miran A., Moussa, Mayssam, Ahmed, Ibrahim A., Karam, Mia, Aldeen, Kawthar Sharaf, Al Sayegh, Rola, El-Achkar, Ghewa A., Nasrallah, Leila, Yehya, Yara, Habib, Aida, Ziyadeh, Fuad N., Eid, Ali H., Kobeissy, Firas H., Jaffa, Ayad A.

“…Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major…”
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Modulation of proteomic and inflammatory signals by Bradykinin in podocytes by Saoud, Richard, Jaffa, Miran A, Habib, Aida, Zhao, Jingfu, Al Hariri, Moustafa, Zhu, Rui, Hasan, Anwarul, Ziyadeh, Fuad N, Kobeissy, Firas, Mechref, Yehia, Jaffa, Ayad A

“…[Display omitted] Podocyte damage is one of the hallmarks of diabetic nephropathy leading to proteinuria and kidney damage. The underlying mechanisms of…”
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Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation by Strutz, Frank, Zeisberg, Michael, Ziyadeh, Fuad N., Yang, Chang-Qing, Kalluri, Raghu, Müller, Gerhard A., Neilson, Eric G., Renziehausen, A., Sisic, Z.

“…Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Epithelial-mesenchymal transformation (EMT) plays an important role in…”
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Long-Term Prevention of Renal Insufficiency, Excess Matrix Gene Expression, and Glomerular Mesangial Matrix Expansion by Treatment with Monoclonal Antitransforming Growth Factor-β Antibody in db/db Diabetic Mice by Ziyadeh, Fuad N., Hoffman, Brenda B., Han, Dong Cheol, Iglesias-De la Cruz, M. Carmen, Hong, Soon Won, Isono, Motohide, Chen, Sheldon, McGowan, Tracy A., Sharma, Kumar

“…Emerging evidence suggests that transforming growth factor-β (TGF-β ) is an important mediator of diabetic nephropathy. We showed previously that short-term…”
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Podocyte-Derived Vascular Endothelial Growth Factor Mediates the Stimulation of α3(IV) Collagen Production by Transforming Growth Factor-β1 in Mouse Podocytes by CHEN, Sheldon, KASAMA, Yuki, LEE, Joseph S, JIM, Belinda, MARIN, Maria, ZIYADEH, Fuad N

“…Podocyte-Derived Vascular Endothelial Growth Factor Mediates the Stimulation of α3(IV) Collagen Production by Transforming Growth Factor-β1 in Mouse Podocytes…”
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Effects of high glucose and TGF-β1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes by Iglesias-de la Cruz, M. Carmen, Ziyadeh, Fuad N., Isono, Motohide, Kouahou, Martine, Han, Dong Cheol, Kalluri, Raghu, Mundel, Peter, Chen, Sheldon

“…Effects of high glucose and TGF-β1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. The podocyte takes center stage…”
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Biospecimen Repositories in Low- and Middle-Income Countries: Insights From an American University of Beirut and Memorial Sloan Kettering Collaboration by Faraj, Walid, Robson, Mark, Tawil, Ayman, Reuter, Victor, Mahfouz, Rami, Cambria, Roy, Saheb, Nour, Ferrer, Christine S, Vemuri, Shreya, Yaghi, Marita, Kanso, Mariam, Abdullah, Abdul, El Nounou, Ghina, Jabbour, Mark, Muenkel, Kerri, Kaufman, Kristopher, Wakim, Joe-Max, Badson, Sandy, Wilson, Roger, Houston, Collette, Drobnjak, Marija, Hoballah, Jamal, Ziyadeh, Fuad N, Zaatari, Ghazi, Brennan, Murray, O'Reilly, Eileen M, Abu-Alfa, Ali K, Abou-Alfa, Ghassan K

“…Biobanking helps source tissue and blood for studying cancer genomics. Access to biorepository resources in low- and middle-income countries is lacking…”
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Assessment of 115 Candidate Genes for Diabetic Nephropathy by Transmission/Disequilibrium Test by EWENS, Kathryn Gogolin, GEORGE, Roberta Ann, SHARMA, Kumar, ZIYADEH, Fuad N, SPIELMAN, Richard S

“…Assessment of 115 Candidate Genes for Diabetic Nephropathy by Transmission/Disequilibrium Test Kathryn Gogolin Ewens 1 , Roberta Ann George 1 , Kumar Sharma 2…”
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Global renal gene expression profiling analysis in B2-kinin receptor null mice: impact of diabetes by Jaffa, Miran A, Kobeissy, Firas, Al Hariri, Moustafa, Chalhoub, Hussein, Eid, Assaad, Ziyadeh, Fuad N, Jaffa, Ayad A

“…Diabetic nephropathy (DN), the leading cause of end-stage renal failure, is clinically manifested by albuminuria and a progressive decline in glomerular…”
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Vascular Cells Proteome Associated with Bradykinin and Leptin Inflammation and Oxidative Stress Signals by Hariri, Moustafa Al, Jaffa, Miran A, Saoud, Richard, Zhao, Jingfu, Zhu, Rui, Jaffa, Aneese A, El-Achkar, Ghewa A, Moussa, Mayssam, Kobeissy, Firas, Hassan, Anwarul, Ziyadeh, Fuad N, Mechref, Yehia, Jaffa, Ayad A

“…Among the primary contributors to cardiovascular diseases are inflammation and oxidative imbalance within the vessel walls as well as the fibrosis of rat…”
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Increased Glomerular and Tubular Expression of Transforming Growth Factor-β1, Its Type II Receptor, and Activation of the Smad Signaling Pathway in the db/db Mouse by Won Hong, Soon, Isono, Motohide, Chen, Sheldon, Iglesias-de la Cruz, M. Carmen, Han, Dong Cheol, Ziyadeh, Fuad N.

“…Activation of the renal transforming growth factor-β (TGF-β) system likely mediates the excess production of extracellular matrix in the diabetic kidney. To…”
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Mediators of diabetic renal disease: The case for TGF-β as the major mediator by ZIYADEH, Fuad N

“…The critical role of hyperglycemia in the genesis of diabetic nephropathy has been established by cell culture studies, experimental animal models, and…”
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