Search Results - "Zivin, J A"

Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study by GOLDSTEIN, L. B, AMARENCO, P, SZAREK, M, CALLAHAN, A, HENNERICI, M, SILLESEN, H, ZIVIN, J. A, WELCH, K. M. A

“…In the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study, atorvastatin 80 mg/day reduced the risk of stroke in patients with…”
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Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes by Lapchak, P.A, Maher, P, Schubert, D, Zivin, J.A

“…Abstract The present study assessed whether baicalein (5,6,7-trihydroxyflavone), a polyphenolic antioxidant 12/15-lipoxygenase inhibitor would attenuate…”
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Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: An extended therapeutic window study using continuous and pulse frequency delivery modes by Lapchak, P.A, Salgado, K.F, Chao, C.H, Zivin, J.A

“…Abstract Photon or near-infrared light therapy (NILT) may be an effective neuroprotective method to reduce behavioral dysfunction following an acute ischemic…”
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Prospective reliability of the STRokE DOC wireless/site independent telemedicine system by MEYER, B. C, LYDEN, P. D, AL-KHOURY, L, CHENG, Y, RAMAN, R, FELLMAN, R, BEER, J, RAO, R, ZIVIN, J. A

“…The authors evaluated a site-independent telemedicine system. Telemedicine may be limited by the need for fixed connectivity. Wireless and site-independent…”
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Factors determining the therapeutic window for stroke by ZIVIN, J. A

“…The duration of the window to treat acute cerebral ischemia has become an important question since the first effective drug for stroke victims has become…”
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Persistent phosphorylation of cyclic amp responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain by Hu, B.R., Fux, C.M., Martone, M.E., Zivin, J.A., Ellisman, M.H.

“…The transcription factors cyclic AMP responsive element-binding protein (CREB) and activating transcription factor-2 were studied in rat brains subjected to 15…”
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Thrombolytic stroke therapy: Past, present, and future by ZIVIN, J. A

“…Until 1995, treatment of strokes consisted exclusively of efforts to prevent recurrence. Proof that tissue plasminogen activator is useful for acute management…”
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The STRokE DOC trial technique: 'video clip, drip, and/or ship' by Meyer, B. C., Raman, R., Rao, R., Fellman, R. D., Beer, J., Werner, J., Zivin, J. A., Lyden, P. D.

“…Rationale To describe the clinical trial methods of a site-independent telemedicine system used in stroke. Aims A lack of readily available stroke expertise…”
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Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke by del Zoppo, G J, Poeck, K, Pessin, M S, Wolpert, S M, Furlan, A J, Ferbert, A, Alberts, M J, Zivin, J A, Wechsler, L, Busse, O

“…An open angiography-based, dose rate escalation study on the effect of intravenous infusion of recombinant tissue plasminogen activator (rt-PA) on cerebral…”
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Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule by CLARK, W. M, MADDEN, K. P, ROTHLEIN, R, ZIVIN, J. A

“…Activated leukocytes appear to be directly involved in potentiating ischemic central nervous system (CNS) injury. Adhesion of leukocytes to endothelium is…”
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Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy by BOWES, M. P, ROTHLEIN, R, FAGAN, S. C, ZIVIN, J. A

“…We evaluated the ability of monoclonal antibodies directed against leukocyte adhesion molecules (intercellular adhesion molecule-1 [ICAM-1], CD18) to enhance…”
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Monoclonal antibody to the ICAM-1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model by Bowes, M P, Zivin, J A, Rothlein, R

“…We evaluated the effect of antibodies directed against a leukocyte adhesion molecule (ICAM-1) in an embolic model of stroke followed by thrombolysis with…”
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NeuroThera Efficacy and Safety Trial - 3 (NEST-3): a double-blind, randomized, sham-controlled, parallel group, multicenter, pivotal study to assess the safety and efficacy of transcranial laser therapy with the NeuroThera Laser System for the treatment of acute ischemic stroke within 24h of stroke onset by Zivin, J A, Sehra, R, Shoshoo, A, Albers, G W, Bornstein, N M, Dahlof, B, Kasner, S E, Howard, G, Shuaib, A, Streeter, J, Richieri, S P, Hacke, W

“…Rationale Transcranial laser therapy is undergoing clinical trials in patients with acute ischemic stroke. The NeuroThera Efficacy and Safety Trial-1 was…”
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NeuroThera® Efficacy and Safety Trial – 3 (NEST-3): A Double-Blind, Randomized, Sham-Controlled, Parallel Group, Multicenter, Pivotal Study to Assess the Safety and Efficacy of Transcranial Laser Therapy with the NeuroThera® Laser System for the Treatment of Acute Ischemic Stroke within 24 h of Stroke Onset by Zivin, J. A., Sehra, R., Shoshoo, A., Albers, G. W., Bornstein, N. M., Dahlof, B., Kasner, S. E., Howard, G., Shuaib, A., Streeter, J., Richieri, S. P., Hacke, W.

“…Rationale Transcranial laser therapy is undergoing clinical trials in patients with acute ischemic stroke. The NeuroThera® Efficacy and Safety Trial-1 was…”
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Quantal bioassay and stroke by ZIVIN, J. A, WAUD, D. R

“…Experimental investigation of stroke, in particular the evaluation of therapeutic maneuvers, is difficult because even well-controlled experiments show…”
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Detection of arterial emboli using Doppler ultrasound in rabbits by Russell, D, Madden, K P, Clark, W M, Sandset, P M, Zivin, J A

“…The purpose of this study was to develop an animal model that could be used to test the ability of Doppler ultrasound to detect arterial emboli composed of…”
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Graded bioassay for demonstration of brain rescue from experimental acute ischemia in rats by Aronowski, J, Ostrow, P, Samways, E, Strong, R, Zivin, J A, Grotta, J C

“…This study explored the correlation between duration of focal ischemia and infarct volume in spontaneously hypertensive rats as a measure of outcome after…”
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Neuroprotective therapies in stroke by Zivin, J A

“…Neuroprotective drugs are known to reduce neurological damage in animal models of stroke, but none are generally accepted for the treatment of patients with…”
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Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment by CLARK, W. M, MADDEN, K. P, ROTHLEIN, R, ZIVIN, J. A

“…Activated leukocytes appear to be directly involved in ischemic central nervous system injury. A surface glycoprotein (CD18) on the leukocyte is required for…”
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Prosaptide exacerbates ischemia-induced behavioral deficits in vivo; an effect that does not involve mitogen-activated protein kinase activation by Lapchak, P.A, Araujo, D.M, Shackelford, D.A, Zivin, J.A

“…Prosaposin is a 517 amino acid membrane component and secreted protein 5,7,9 that is proteolytically cleaved to generate the four small glycoproteins; saposins…”
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