Optimizing the average distance between a blue light photosensitizer and a harmonic nanoparticle for effective infrared photodynamic therapy

[Display omitted] •Curcumin is NIR photodynamically responsive upon coupling with BT nanoparticles.•Protoporphyrin IX also becomes NIR photodynamically responsive after such coupling.•Tuning the intermediary coupling distance amplifies the NIR photodynamic response.•MCF7 cancer cells achieve optimal...

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Bibliographic Details
Published in:	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 303; p. 123195
Main Authors:	Barbora, Ayan, Lyssenko, Svetlana, Amar, Michal, Nave, Vadim, Zivan, Vered, Argaev Frenkel, Lital, Nause, Ariel, Cohen-Harazi, Raichel, Minnes, Refael
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 15-12-2023
Subjects:	Near Infrared Laser Perovskite Photodynamic Therapy Photosensitizer Second Harmonic Nanoparticles Perovskite Near Infrared Laser Second Harmonic Nanoparticles Photodynamic Therapy Photosensitizer
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Summary:	[Display omitted] •Curcumin is NIR photodynamically responsive upon coupling with BT nanoparticles.•Protoporphyrin IX also becomes NIR photodynamically responsive after such coupling.•Tuning the intermediary coupling distance amplifies the NIR photodynamic response.•MCF7 cancer cells achieve optimal absorption of these drugs within 30 min.•Treated cells subjected to NIR light radiation are eliminated by 64–73 percent. Photodynamic therapy can be significantly improved by techniques utilizing light windows of higher tissue penetration depths with optimally matched photoactive agents to provide deep interstitial treatment. Classical blue light photosensitizers were photodynamically activated using infrared light via coupled harmonic nanoparticles with optimized intermediary distances using spacers. Upon 800 nm pulsed laser irradiation perovskite nanoparticles with optimized coupling to either curcumin or protoporphyrin IX reduced the viability of MCF7 breast cancer cells by 73 percent and 64 percent, respectively, while exhibiting negligible dark toxicity. The findings pave the way for clinical adaptation of ease-of-synthesis photodynamically active preparations operable under deep tissue penetrating infrared lights using commonly available otherwise infrared inactive classical blue light photosensitizers.
ISSN:	1386-1425
DOI:	10.1016/j.saa.2023.123195