Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia

Clinical and prognostic differences between symptomatic and asymptomatic older patients with COVID-19 are of great interest since frail patients often show atypical presentation of illness. Lung Ultrasound (LUS) has been proven to be a reliable tool for detecting early-phase COVID-19 pneumonic alter...

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Published in:	Scientific reports Vol. 11; no. 1; pp. 22892 - 8
Main Authors:	Okoye, Chukwuma, Calsolaro, Valeria, Fabbri, Alessandra, Franchi, Riccardo, Antognoli, Rachele, Zisca, Ludovica, Bianchi, Camilla, Calabrese, Alessia Maria, Rogani, Sara, Monzani, Fabio
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24-11-2021 Nature Publishing Group Nature Portfolio
Subjects:	692/1807 692/699 692/700 Aged Aged, 80 and over Asymptomatic Asymptomatic Diseases - epidemiology Coronaviruses COVID-19 COVID-19 - complications COVID-19 - diagnostic imaging COVID-19 - mortality Female Frailty Hospitalization Humanities and Social Sciences Humans Lung - diagnostic imaging Lung - pathology Male Mortality multidisciplinary Patients Pneumonia - diagnostic imaging Pneumonia - immunology Prognosis Prospective Studies SARS-CoV-2 - metabolism SARS-CoV-2 - pathogenicity Science Science (multidisciplinary) Survival Tomography, X-Ray Computed - methods Ultrasonic imaging Ultrasonography - methods Ultrasound
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Summary:	Clinical and prognostic differences between symptomatic and asymptomatic older patients with COVID-19 are of great interest since frail patients often show atypical presentation of illness. Lung Ultrasound (LUS) has been proven to be a reliable tool for detecting early-phase COVID-19 pneumonic alterations. The current prospective bicentric study aimed to compare LUS score and 3-month overall mortality between asymptomatic and symptomatic older patients with COVID-19, according to frailty status. Patients were stratified according to LUS score tertiles and Clinical Frailty Scale categories. Survival rate was assessed by telephone interviews 3 months after discharge. 64 symptomatic (24 women, aged 80.0 ± 10.8 years) and 46 asymptomatic (31 women, aged 84.3 ± 8.8 years) were consecutively enrolled. LUS score resulted an independent predictor of 3-month mortality [OR 2.27 (CI95% 1.09–4.8), p = 0.03], and the highest mortality rate was observed in symptomatic and asymptomatic pre-frail and frail patients (70.6% and 66.7%, respectively) with greater LUS abnormalities (3rd tertile). In conclusion, LUS identified an acute interstitial lung involvement in most of the older asymptomatic patients. Mortality rate progressively increased according to clinical frailty and LUS score degree, resulting a reliable prognostic tool in both symptomatic and asymptomatic patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-02275-2