Search Results - "Zippin, Jonathan H."

Cyclic adenosine monophosphate (cAMP) signaling in melanocyte pigmentation and melanomagenesis by Bang, Jakyung, Zippin, Jonathan H.

“…The second messenger cyclic adenosine monophosphate (cAMP) regulates numerous functions in both benign melanocytes and melanoma cells. cAMP is generated from…”
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Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid by Lehmann, Guillermo L, Hanke-Gogokhia, Christin, Hu, Yang, Bareja, Rohan, Salfati, Zelda, Ginsberg, Michael, Nolan, Daniel J, Mendez-Huergo, Santiago P, Dalotto-Moreno, Tomas, Wojcinski, Alexandre, Ochoa, Francisca, Zeng, Shemin, Cerliani, Juan P, Panagis, Lampros, Zager, Patrick J, Mullins, Robert F, Ogura, Shuntaro, Lutty, Gerard A, Bang, Jakyung, Zippin, Jonathan H, Romano, Carmelo, Rabinovich, Gabriel A, Elemento, Olivier, Joyner, Alexandra L, Rafii, Shahin, Rodriguez-Boulan, Enrique, Benedicto, Ignacio

“…The activity and survival of retinal photoreceptors depend on support functions performed by the retinal pigment epithelium (RPE) and on oxygen and nutrients…”
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The potential impact of melanosomal pH and metabolism on melanoma by You, Jaewon, Yusupova, Maftuna, Zippin, Jonathan H

“…Melanin is synthesized in melanocytes and is transferred into keratinocytes to block the effects of ultraviolet (UV) radiation and is important for preventing…”
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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase by Ramos-Espiritu, Lavoisier, Kleinboelting, Silke, Navarrete, Felipe A, Alvau, Antonio, Visconti, Pablo E, Valsecchi, Federica, Starkov, Anatoly, Manfredi, Giovanni, Buck, Hannes, Adura, Carolina, Zippin, Jonathan H, van den Heuvel, Joop, Glickman, J Fraser, Steegborn, Clemens, Levin, Lonny R, Buck, Jochen

“…Editorial summary A high-throughput screen using a mass-spectrometry-based assay results in the identification of LRE1 as an inhibitor of HCO 3 − /Ca 2+…”
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Type I hypersensitivity in photoallergic contact dermatitis by Afvari, Shawn, Zippin, Jonathan H.

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Stoma care products represent a common and previously underreported source of peristomal contact dermatitis by Cressey, Brienne D., Belum, Viswanath R., Scheinman, Pamela, Silvestri, Dianne, McEntee, Nancy, Livingston, Vashti, Lacouture, Mario E., Zippin, Jonathan H.

“…Summary Background Peristomal dermatitis is a common complication for the >700 000 patients in the United States with an ostomy. The role of stoma skin care…”
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Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma by Trousil, Sebastian, Chen, Shuang, Mu, Chan, Shaw, Fiona M., Yao, Zhan, Ran, Yuping, Shakuntala, Tiwari, Merghoub, Taha, Manstein, Dieter, Rosen, Neal, Cantley, Lewis C., Zippin, Jonathan H., Zheng, Bin

“…Inactivation of the tumor suppressor neurofibromin 1 (NF1) presents a newly characterized melanoma subtype, for which currently no targeted therapies are…”
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Computational Investigation of the pH Dependence of Stability of Melanosome Proteins: Implication for Melanosome formation and Disease by Koirala, Mahesh, Shashikala, H B Mihiri, Jeffries, Jacob, Wu, Bohua, Loftus, Stacie K, Zippin, Jonathan H, Alexov, Emil

“…Intravesicular pH plays a crucial role in melanosome maturation and function. Melanosomal pH changes during maturation from very acidic in the early stages to…”
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Allergic Contact Dermatitis to Cosmetics by Park, Michelle E, Zippin, Jonathan H., MD, PhD

“…Allergic contact dermatitis caused by cosmetic products is an increasing concern given the continual creation and introduction of new cosmetics to the public…”
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The “Soluble” Adenylyl Cyclase in Sperm Mediates Multiple Signaling Events Required for Fertilization by Hess, Kenneth C., Jones, Brian H., Marquez, Becky, Chen, Yanqiu, Ord, Teri S., Kamenetsky, Margarita, Miyamoto, Catarina, Zippin, Jonathan H., Kopf, Gregory S., Suarez, Susan S., Levin, Lonny R., Williams, Carmen J., Buck, Jochen, Moss, Stuart B.

“…Mammalian fertilization is dependent upon a series of bicarbonate-induced, cAMP-dependent processes sperm undergo as they “capacitate,” i.e., acquire the…”
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The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus by Li, Thomas Morgan, Zyulina, Victoria, Seltzer, Ethan S, Dacic, Marija, Chinenov, Yurii, Daamen, Andrea R, Veiga, Keila R, Schwartz, Noa, Oliver, David J, Cabahug-Zuckerman, Pamela, Lora, Jose, Liu, Yong, Shipman, 3rd, William D, Ambler, William G, Taber, Sarah F, Onel, Karen B, Zippin, Jonathan H, Rashighi, Mehdi, Krueger, James G, Anandasabapathy, Niroshana, Rogatsky, Inez, Jabbari, Ali, Blobel, Carl P, Lipsky, Peter E, Lu, Theresa T

“…The autoimmune disease lupus erythematosus (lupus) is characterized by photosensitivity, where even ambient ultraviolet radiation (UVR) exposure can lead to…”
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Chemical and biochemical control of skin pigmentation with special emphasis on mixed melanogenesis by Wakamatsu, Kazumasa, Zippin, Jonathan H., Ito, Shosuke

“…Melanins are widely distributed in animals and plants; in vertebrates, most melanins are present on the body surface. The diversity of pigmentation in…”
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A randomized trial of a wearable UV dosimeter for skin cancer prevention by Dumont, Emmanuel L P, Kaplan, Peter D, Do, Catherine, Banerjee, Shayak, Barrer, Melissa, Ezzedine, Khaled, Zippin, Jonathan H, Varghese, George I

“…Non-melanoma skin cancer (NMSC) is the most prevalent cancer in the United States. Despite guidelines on ultraviolet (UV) avoidance, it remains difficult for…”
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Photodermatoses in patients with atopic dermatitis: A 10-year retrospective cohort study by Afvari, Shawn, Zippin, Jonathan H.

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Compartmentalization of bicarbonate‐sensitive adenylyl cyclase in distinct signaling microdomains by Zippin, Jonathan H., Chen, Yanqiu, Nahirney, Patrick, Kamenetsky, Margarita, Wuttke, Mark S., Fischman, Donald A., Levin, Lonny R., Buck, Jochen

“…ABSTRACT Intracellular targets of the ubiquitous second messenger cAMP are located at great distances from the most widely studied source of cAMP, the G…”
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The impact of cancer history on the prevalence of type IV hypersensitivity: A 9-year matched retrospective cohort study by Shtaynberger, Benjamin, Zippin, Jonathan H.

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Bicarbonate-Responsive "Soluble" Adenylyl Cyclase Defines a Nuclear cAMP Microdomain by Zippin, Jonathan H., Farrell, Jeanne, Huron, David, Kamenetsky, Margarita, Hess, Kenneth C., Fischman, Donald A., Levin, Lonny R., Buck, Jochen

“…Bicarbonate-responsive "soluble" adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein…”
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Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms by DiNapoli, Sara E, Martinez-McFaline, Raúl, Shen, Hao, Doane, Ashley S, Perez, Alexendar R, Verma, Akanksha, Simon, Amanda, Nelson, Isabel, Balgobin, Courtney A, Bourque, Caitlin T, Yao, Jun, Raman, Renuka, Béguelin, Wendy, Zippin, Jonathan H, Elemento, Olivier, Melnick, Ari M, Houvras, Yariv

“…Perturbations to the epigenome are known drivers of tumorigenesis. In melanoma, alterations in histone methyltransferases that catalyze methylation at histone…”
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Soluble Adenylyl Cyclase Mediates Nerve Growth Factor-induced Activation of Rap1 by Stessin, Alexander M., Zippin, Jonathan H., Kamenetsky, Margarita, Hess, Kenneth C., Buck, Jochen, Levin, Lonny R.

“…Nerve growth factor (NGF) and the ubiquitous second messenger cyclic AMP (cAMP) are both implicated in neuronal differentiation. Multiple studies indicate that…”
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Tumour extracellular vesicles and particles induce liver metabolic dysfunction by Wang, Gang, Li, Jianlong, Bojmar, Linda, Chen, Haiyan, Li, Zhong, Tobias, Gabriel C., Hu, Mengying, Homan, Edwin A., Lucotti, Serena, Zhao, Fengbo, Posada, Valentina, Oxley, Peter R., Cioffi, Michele, Kim, Han Sang, Wang, Huajuan, Lauritzen, Pernille, Boudreau, Nancy, Shi, Zhanjun, Burd, Christin E., Zippin, Jonathan H., Lo, James C., Pitt, Geoffrey S., Hernandez, Jonathan, Zambirinis, Constantinos P., Hollingsworth, Michael A., Grandgenett, Paul M., Jain, Maneesh, Batra, Surinder K., DiMaio, Dominick J., Grem, Jean L., Klute, Kelsey A., Trippett, Tanya M., Egeblad, Mikala, Paul, Doru, Bromberg, Jacqueline, Kelsen, David, Rajasekhar, Vinagolu K., Healey, John H., Matei, Irina R., Jarnagin, William R., Schwartz, Robert E., Zhang, Haiying, Lyden, David

“…Cancer alters the function of multiple organs beyond those targeted by metastasis 1 , 2 . Here we show that inflammation, fatty liver and dysregulated…”
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