Search Results - "Zipfel, P.F."

Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II) by Licht, C., Heinen, S., Józsi, M., Löschmann, I., Saunders, R.E., Perkins, S.J., Waldherr, R., Skerka, C., Kirschfink, M., Hoppe, B., Zipfel, P.F.

“…We report a novel pathomechanism for membranoproliferative glomerulonephritis type II (MPGN II) caused by a mutant Factor H protein expressed in the plasma…”
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Pra1 from Candida albicans has a metalloprotease function to cleave the central complement component C3 by Pilz, C., Luo, S., Hartmann, A., Skerka, C., Zipfel, P.F.

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Expression of recombinant ARMS2 and binding to self cell surfaces via glycosaminoglycans by Micklisch, S., Schult, K., Zipfel, P.F., Skerka, C.

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Elongation Factor Tu (Tuf) is a new virulence factor of Streptococcus pneumoniae that binds human complement factors, aids in immune evasion and host tissue invasion by Sarkar, S., Hallström, T., Hammerschmidt, S., Skerka, C., Zipfel, P.F.

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Identification of a novel hybrid CFHR2/CFHR5 gene in MPGN II/DDD patients by Chen, Q., Hugo, C., Zipfel, P.F.

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Antibody Mediated Rejection Associated With Complement Factor H–Related Protein 3/1 Deficiency Successfully Treated With Eculizumab by Noone, D., Al‐Matrafi, J., Tinckam, K., Zipfel, P. F., Herzenberg, A. M., Thorner, P. S., Pluthero, F. G., Kahr, W. H. A., Filler, G., Hebert, D., Harvey, E., Licht, C.

“…Antibody mediated rejection (AMR) activates the classical complement pathway and can be detrimental to graft survival. AMR can be accompanied by thrombotic…”
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Glycerol-3-phosphate dehydrogenase 2 is a novel Candida albicans complement inhibitor by Luo, S., Reza, M., Hoffmann, R., Skerka, C., Verschoor, A., Zipfel, P.F.

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CspA from Borrelia burgdorferi inhibits the terminal complement pathway by Hallström, T., Siegel, C., Mörgelin, M., Kraiczy, P., Skerka, C., Zipfel, P.F.

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The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin by Hallström, T., Voss, S., Singh, B., Riesbeck, K., Hammerschmidt, S., Zipfel, P.F.

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Sequence variations and expression of the Candida albicans immune evasion proteins Gpm1 and Pra1 in clinical isolates contribute to virulence by Luo, S., Hipler, U.-C., Münzberg, C., Skerka, C., Verschoor, A., Zipfel, P.F.

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C3 convertase antibodies in membranoproliferative glomerulonephritis by Lindner, S., Chen, Q., Kirschfink, M., Nilsson, B., Nilsson-Ekdahl, K., Wolf, G., Zipfel, P.F.

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Complement deregulation in dense deposit disease by a novel CFHR2–CFHR5 hybrid protein by Chen, Q., Wiesener, M., Eberhardt, H.U., Hartmann, A., Kirschfink, M., Amann, K., Buettner, M., Goodship, T., Hugo, C., Skerka, C., Zipfel, P.F.

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Shiga toxin 2 binds and modulates complement regulatory proteins in the fluid phase and on host cell membranes by Orth-Höller, D., Ehrlenbach, S., Rosales, A., Poolpol, K., Zipfel, P.F., Skerka, C., Córdoba, S. Rodríguez De, Karpman, D., Karch, H., Würzner, R.

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Trimer Stability of YadA Is Critical for Virulence of Yersinia enterocolitica by Schütz, M, Weiss, E.-M, Schindler, M, Hallström, T, Zipfel, P.F, Linke, D, Autenrieth, I.B

“…Yersinia adhesin A (YadA) is a trimeric autotransporter adhesin with multiple functions in host-pathogen interactions. The aim of this study was to dissect the…”
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Pra1 binds and inactivates effector functions of the anaphylatoxin C3a by Kupka, D., Wende, E., Klos, A., Zipfel, P.F.

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Immune evasion by acquisition of complement inhibitors: The mould Aspergillus binds both factor H and C4b binding protein by Vogl, G., Lesiak, I., Jensen, D.B., Perkhofer, S., Eck, R., Speth, C., Lass-Flörl, C., Zipfel, P.F., Blom, A.M., Dierich, M.P., Würzner, R.

“…Pathogenic fungi represent a major threat particularly to immunocompromised hosts, leading to severe, and often lethal, systemic opportunistic infections…”
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Pseudomonas aeruginosa Lipoamide dehydrogenase (Lpd) binds multiple human plasma proteins for immune escape and to facilitate tissue interaction by Hallström, T., Barthel, D., Singh, B., Mörgelin, M., Skerka, C., Riesbeck, K., Zipfel, P.F.

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Borrelia valaisiana overcome complement-mediated killing independendly from the recruitment of complement regulators by Kraiczy, P., Schwab, J., Hammerschmidt, C., Richter, D., Skerka, C., Matuschka, F.-R., Zipfel, P.F.

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Factor H binds to washed human platelets by Vaziri‐Sani, F., Hellwage, J., Zipfel, P. F., Sjöholm, A. G., Iancu, R., Karpman, D.

“…Background: Factor H regulates the alternative pathway of complement. The protein has three heparin‐binding sites, is synthesized primarily in the liver and…”
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The baculovirus expression vector pBSV-8His directs secretion of histidine-tagged proteins by Kühn, Sabine, Zipfel, Peter F.

“…A novel baculovirus expression vector (pBSV-8His) directs secretion of recombinant proteins into the culture medium of infected insect cells. By providing a…”
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