Search Results - "Zipfel, P"

Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H by Mihlan, M, Stippa, S, Józsi, M, Zipfel, P F

“…Complement forms the first defense line of innate immunity and has an important role in the non-inflammatory clearance of apoptotic and necrotic cells. Factor…”
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Complement in age-related macular degeneration: a focus on function by Bradley, D T, Zipfel, P F, Hughes, A E

“…Age-related macular degeneration (AMD) is an inflammatory disease, which causes visual impairment and blindness in older people. The proteins of the complement…”
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The C‐terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein by Oppermann, M., Manuelian, T., Józsi, M., Brandt, E., Jokiranta, T. S., Heinen, S., Meri, S., Skerka, C., Götze, O., Zipfel, P. F.

“…Summary The complement inhibitor Factor H has three distinct binding sites for C3b and for heparin, but in solution uses specifically the most C‐terminal…”
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Haemolytic uraemic syndrome and mutations of the factor H gene: a registry-based study of German speaking countries by Neumann, H P H, Salzmann, M, Bohnert-Iwan, B, Mannuelian, T, Skerka, C, Lenk, D, Bender, B U, Cybulla, M, Riegler, P, Königsrainer, A, Neyer, U, Bock, A, Widmer, U, Male, D A, Franke, G, Zipfel, P F

“…Background: The aetiology of atypical haemolytic uraemic syndrome (aHUS) is, in contrast to classical, Shiga-like toxin induced HUS in children, largely…”
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Antibody Mediated Rejection Associated With Complement Factor H–Related Protein 3/1 Deficiency Successfully Treated With Eculizumab by Noone, D., Al‐Matrafi, J., Tinckam, K., Zipfel, P. F., Herzenberg, A. M., Thorner, P. S., Pluthero, F. G., Kahr, W. H. A., Filler, G., Hebert, D., Harvey, E., Licht, C.

“…Antibody mediated rejection (AMR) activates the classical complement pathway and can be detrimental to graft survival. AMR can be accompanied by thrombotic…”
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Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease) by Abrera-Abeleda, M A, Nishimura, C, Smith, J L H, Sethi, S, McRae, J L, Murphy, B F, Silvestri, G, Skerka, C, Józsi, M, Zipfel, P F, Hageman, G S, Smith, R J H

“…Introduction: Membranoproliferative glomerulonephritis type II or dense deposit disease (MPGN II/DDD) causes chronic renal dysfunction that progresses to end…”
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The Hyphal and Yeast Forms of Candida albicans Bind the Complement Regulator C4b-Binding Protein by MERI, T, BLOM, A. M, HARTMANN, A, LENK, D, MERI, S, ZIPFEL, P. F

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Trimer Stability of YadA Is Critical for Virulence of Yersinia enterocolitica by Schütz, M, Weiss, E.-M, Schindler, M, Hallström, T, Zipfel, P.F, Linke, D, Autenrieth, I.B

“…Yersinia adhesin A (YadA) is a trimeric autotransporter adhesin with multiple functions in host-pathogen interactions. The aim of this study was to dissect the…”
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Factor H family proteins: on complement, microbes and human diseases by Zipfel, P F, Skerka, C, Hellwage, J, Jokiranta, S T, Meri, S, Brade, V, Kraiczy, P, Noris, M, Remuzzi, G

“…At present, the human Factor H protein family represents seven multidomain, multifunctional serum proteins. This group includes the complement and immune…”
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Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II) by Licht, C., Heinen, S., Józsi, M., Löschmann, I., Saunders, R.E., Perkins, S.J., Waldherr, R., Skerka, C., Kirschfink, M., Hoppe, B., Zipfel, P.F.

“…We report a novel pathomechanism for membranoproliferative glomerulonephritis type II (MPGN II) caused by a mutant Factor H protein expressed in the plasma…”
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The Yeast Candida albicans Binds Complement Regulators Factor H and FHL-1 by MERI, T, HARTMANN, A, LENK, D, ECK, R, WÜRZNER, R, HELLWAGE, J, MERI, S, ZIPFEL, P. F

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Ral activation promotes melanomagenesis by Zipfel, P A, Brady, D C, Kashatus, D F, Ancrile, B D, Tyler, D S, Counter, C M

“…Up to one-third of human melanomas are characterized by an oncogenic mutation in the gene encoding the small guanosine triphosphatase (GTPase) NRAS . Ras…”
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Further Characterization of Complement Regulator-Acquiring Surface Proteins of Borrelia burgdorferi by KRAICZY, Peter, SKERKA, Christine, BRADE, Volker, ZIPFEL, Peter F

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Secretion of soluble complement inhibitors factor H and factor H-like protein (FHL-1) by ovarian tumour cells by JUNNIKKALA, S, HAKULINEN, J, JARVA, H, MANUELIAN, T, BJØRGE, L, BÜTZOW, R, ZIPFEL, P. F, MERI, S

“…We observed that the soluble complement regulators factor H and factor H-like protein were abundantly present in ascites samples as well as in primary tumours…”
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Exceptional Resistance of Human H2 Glioblastoma Cells to Complement-Mediated Killing by Expression and Utilization of Factor H and Factor H-Like Protein 1 by Junnikkala, S, Jokiranta, T. S, Friese, M. A, Jarva, H, Zipfel, P. F, Meri, S

“…Of over 20 nucleated cell lines we have examined to date, human H2 glioblastoma cells have turned out to be the most resistant to complement-mediated cytolysis…”
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Complement factor H deficiency and endocapillary glomerulonephritis due to paternal isodisomy and a novel factor H mutation by Schejbel, L, Schmidt, I M, Kirchhoff, M, Andersen, C B, Marquart, H V, Zipfel, P, Garred, P

“…Complement factor H (CFH) is a regulator of the alternative complement activation pathway. Mutations in the CFH gene are associated with atypical hemolytic…”
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Optimizing Melphalan Pharmacokinetics in Regional Melanoma Therapy: Does Correcting for Ideal Body Weight Alter Regional Response or Toxicity? by McMahon, N., Cheng, T. Y., Beasley, G. M., Spasojevic, I., Petros, W., Augustine, C. K., Zipfel, P., Padussis, J. C., Sanders, G., Tyler, Douglas S.

“…Background This study aims to determine what effect correcting melphalan dosing for ideal body weight (IBW) has on toxicity and response in isolated limb…”
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Role of CRASP-4 in complement resistance of B. burgdorferi by Hammerschmidt, C., Skerka, C., Stevenson, B., Zipfel, P., Kraiczy, P.

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Human complement factor H-related protein 2 (CFHR2) represents a novel complement regulator, which is reduced in a patient with MPGN I by Eberhardt, H.E., Chen, Q., Zipfel, P., Skerka, C.

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Immune evasion by acquisition of complement inhibitors: The mould Aspergillus binds both factor H and C4b binding protein by Vogl, G., Lesiak, I., Jensen, D.B., Perkhofer, S., Eck, R., Speth, C., Lass-Flörl, C., Zipfel, P.F., Blom, A.M., Dierich, M.P., Würzner, R.

“…Pathogenic fungi represent a major threat particularly to immunocompromised hosts, leading to severe, and often lethal, systemic opportunistic infections…”
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