Search Results - "Zioncheck, Thomas F"

A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans by Eppler, Stephen M., Combs, Daniel L., Henry, Timothy D., Lopez, John J., Ellis, Stephen G., Yi, Joo‐Hee, Annex, Brian H., McCluskey, Edward R., Zioncheck, Thomas F.

“…Background The Vascular Endothelial Growth Factor (VEGF) in Ischemiafor Vascular Angiogenesis (VIVA) trial was a double‐blind, placebo‐controlled, phase II…”
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KDR (VEGF Receptor 2) Is the Major Mediator for the Hypotensive Effect of VEGF by Li, Bing, Ogasawara, Annie K, Yang, Renhui, Wei, Wei, He, Guo-Wei, Zioncheck, Thomas F, Bunting, Stuart, de Vos, Abraham M, Jin, Hongkui

“…Vascular endothelial growth factor (VEGF) exerts vasodilation-induced hypotension as a major side effect for treatment of ischemic diseases. VEGF has 2…”
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In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models by Kolinsky, Kenneth, Shen, Ben-Quan, Zhang, Yu-E, Kohles, Joseph, Dugan, Ute, Zioncheck, Thomas F, Heimbrook, David, Packman, Kathryn, Higgins, Brian

“…Modifying the capecitabine dosing schedule from 14 days on, 7 days off (14/7) to 7 days on, 7 days off (7/7) may enable higher doses and improved antitumor…”
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Vascular Endothelial Growth Factor Governs Endothelial Nitric-oxide Synthase Expression via a KDR/Flk-1 Receptor and a Protein Kinase C Signaling Pathway by Shen, Ben-Quan, Lee, David Y., Zioncheck, Thomas F.

“…The mechanism by which vascular endothelial growth factor (VEGF) regulates endothelial nitric-oxide synthase (eNOS) expression is presently unclear. Here we…”
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Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease by Henry, Timothy D., Rocha-Singh, Krishna, Isner, Jeffrey M., Kereiakes, Dean J., Giordano, Frank J., Simons, Michael, Losordo, Douglas W., Hendel, Robert C., Bonow, Robert O., Eppler, Stephen M., Zioncheck, Thomas F., Holmgren, Eric B., McCluskey, Edward R.

“…Background Patients with severe myocardial ischemia who are not candidates for percutaneous or surgical revascularization have few therapeutic options…”
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Apolipoprotein(a): expression and characterization of a recombinant form of the protein in mammalian cells by Koschinsky, Marlys L, Tomlinson, James E, Zioncheck, Thomas F, Schwartz, Karen, Eaton, Dan L, Lawn, Richard M

“…We have stably expressed a recombinant form of apo(a) in a human embryonic kidney cell line. The engineered protein (predicted mass of 250 kDa) contains 17…”
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Homologous Up-regulation of KDR/Flk-1 Receptor Expression by Vascular Endothelial Growth Factor in Vitro by Shen, Ben-Quan, Lee, David Y., Gerber, Hans-Peter, Keyt, Bruce A., Ferrara, Napoleone, Zioncheck, Thomas F.

“…We investigated the possibility that vascular endothelial growth factor (VEGF) treatment could regulate KDR/Flk-1 receptor expression in endothelial cells…”
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Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor by Ebner, Reinhard, Chen, Ruey-Hwa, Shum, Lillian, Lawler, Sean, Zioncheck, Thomas F., Lee, Angela, Lopez, Alfredo R., Derynck, Rik

“…Transforming growth factor-β (TGF-β) affects cellular proliferation, differentiation, and interaction with the extracellular matrix primarily through…”
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Sulfated Oligosaccharides Promote Hepatocyte Growth Factor Association and Govern Its Mitogenic Activity by Zioncheck, Thomas F., Richardson, Louise, Liu, Jun, Chang, Ling, King, Kathleen L., Bennett, Gregory L., Fügedi, Pèter, Chamow, Steven M., Schwall, Ralph H., Stack, Robert J.

“…Hepatocyte growth factor (HGF) is a potent mitogen, motogen, and morphogen for various epithelial cell types. The pleiotropic effects of HGF are mediated by…”
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Exaggerated Hypotensive Effect of Vascular Endothelial Growth Factor in Spontaneously Hypertensive Rats by Yang, Renhui, Ogasawara, Annie K, Zioncheck, Thomas F, Ren, Zhen, He, Guo-Wei, DeGuzman, Geralyn G, Pelletier, Nicolas, Shen, Ben-Quan, Bunting, Stuart, Jin, Hongkui

“…Vascular endothelial growth factor (VEGF) induces hypotension in normotensive subjects, which is considered to be a major side effect for treatment of ischemic…”
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Vascular Endothelial Growth Factor KDR Receptor Signaling Potentiates Tumor Necrosis Factor-induced Tissue Factor Expression in Endothelial Cells by Shen, Ben-Quan, Lee, David Y., Cortopassi, Karen M., Damico, Lisa A., Zioncheck, Thomas F.

“…Vascular endothelial growth factor (VEGF) and tumor necrosis factor-α (TNF-α) have been shown to synergistically increase tissue factor (TF) expression in…”
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Vascular Endothelial Growth Factor-Induced Nitric Oxide- and PGI2-Dependent Relaxation in Human Internal Mammary Arteries: A Comparative Study with KDR and Flt-1 Selective Mutants by Wei, Wei, Jin, Hongkui, Chen, Zhi-Wu, Zioncheck, Thomas F, Yim, Anthony P. C, He, Guo-Wei

“…The role of the vascular endothelial growth factors (VEGF) receptors (KDR and Flt-1) and their characteristics in VEGF-induced vasodilation in human vessels is…”
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Vascular endothelial growth factor-mediated endothelium-dependent relaxation is blunted in spontaneously hypertensive rats by Liu, M H, Jin, H K, Floten, H S, Yang, Q, Yim, A P, Furnary, A, Zioncheck, T F, Bunting, S, He, G W

“…The vasodilatory effect of VEGF has not been characterized in the setting of hypertension. This study investigated the in vitro vasorelaxant effects of VEGF in…”
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Analysis of Biological Effects and Signaling Properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2) by Gille, Hendrik, Kowalski, Joe, Li, Bing, LeCouter, Jennifer, Moffat, Barbara, Zioncheck, Thomas F., Pelletier, Nicolas, Ferrara, Napoleone

“…Endothelial cells express two related vascular endothelial growth factor (VEGF) receptor tyrosine kinases, KDR (kinase-insert domain containing receptor, or…”
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Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants by Gille, H, Kowalski, J, Li, B, LeCouter, J, Moffat, B, Zioncheck, T F, Pelletier, N, Ferrara, N

“…Endothelial cells express two related vascular endothelial growth factor (VEGF) receptor tyrosine kinases, KDR (kinase-insert domain containing receptor, or…”
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Physical properties of recombinant apolipoprotein(a) and its association with LDL to form an Lp(a)-like complex by Phillips, Martin L, Lembertas, Audra V, Schumaker, Verne N, Lawn, Richard M, Shire, Steven J, Zioncheck, Thomas F

“…Recombinant apolipoprotein(a) has been studied by hydrodynamic techniques and electron microscopy. Recombinant apo(a) was primarily a monomer in solution with…”
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Exaggerated hypotensive effect of vasular endothelial growth factor in spontaneously hypertensive rats by Yang, Renhui, Ogasawara, Annie K, Zioncheck, Thomas F, Ren, Zhen

“…Vascular endothelial growth factor (VEGF) induces hypotension in normotensive subjects, which is considered to be a major side effect for treatment of ischemic…”
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Heparin Induces Dimerization and Confers Proliferative Activity onto the Hepatocyte Growth Factor Antagonists NK1 and NK2 by Schwall, Ralph H., Chang, Ling Y., Godowski, Paul J., Kahn, David W., Hillan, Kenneth J., Bauer, Kenneth D., Zioncheck, Thomas F.

“…Hepatocyte growth factor (HGF) is a potent epithelial mitogen whose actions are mediated through its receptor, the proto-oncogene c-Met. Two truncated variants…”
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Substantially attenuated hemodynamic responses to Escherichia coli-derived vascular endothelial growth factor given by intravenous infusion compared with bolus injection by Yang, R, Bunting, S, Ko, A, Keyt, B A, Modi, N B, Zioncheck, T F, Ferrara, N, Jin, H

“…Vascular endothelial growth factor (VEGF) produces beneficial angiogenesis in animal models of coronary and peripheral ischemia. However, intravenous bolus…”
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The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism by ZIONCHECK, T. F, ROY, S, VEHAR, G. A

“…Tissue factor (TF) is an integral membrane glycoprotein that serves as a cellular receptor and cofactor for the activation of the plasma protease factor VII…”
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