Search Results - "Zintchenko, Arkadi"

Hydrophobically Modified Oligoethylenimines as Highly Efficient Transfection Agents for siRNA Delivery by Philipp, Alexander, Zhao, Xiaobin, Tarcha, Peter, Wagner, Ernst, Zintchenko, Arkadi

“…RNA interference is a promising therapeutic strategy for treatment of diseases, in particular, cancer. Despite a huge number of targets identified for…”
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Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity by Zintchenko, Arkadi, Philipp, Alexander, Dehshahri, Ali, Wagner, Ernst

“…Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current…”
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Transition Highly Aggregated ComplexesSoluble Complexes via Polyelectrolyte Exchange Reactions:  Kinetics, Structural Changes, and Mechanism by Zintchenko, Arkadi, Rother, Gudrun, Dautzenberg, Herbert

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Comprehensive study of the drug delivery properties of poly(l-lactide)-poly(ethylene glycol) nanoparticles in rats and tumor-bearing mice by Shalgunov, Vladimir, Zaytseva-Zotova, Daria, Zintchenko, Arkadi, Levada, Tatiana, Shilov, Yuri, Andreyev, Dmitry, Dzhumashev, Dzhangar, Metelkin, Evgeny, Urusova, Alexandra, Demin, Oleg, McDonnell, Kevin, Troiano, Greg, Zale, Stephen, Safarovа, Elmira

“…Nanoparticles made of polylactide-poly(ethylene glycol) block-copolymer (PLA-PEG) are promising vehicles for drug delivery due to their biodegradability and…”
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A dimethylmaleic acid-melittin-polylysine conjugate with reduced toxicity, pH-triggered endosomolytic activity and enhanced gene transfer potential by Meyer, Martin, Zintchenko, Arkadi, Ogris, Manfred, Wagner, Ernst

“…Background Poor endosomal release is one major barrier of gene delivery. Endosomolytic polyethylenimine‐melittin conjugates have shown to enhance gene transfer…”
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Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals by Zintchenko, Arkadi, Susha, Andrei S, Concia, Massimo, Feldmann, Jochen, Wagner, Ernst, Rogach, Andrey L, Ogris, Manfred

“…The knowledge of the biodistribution of macromolecular drug formulations is a key to their successful development for specific tissue- and tumor-targeting…”
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Temperature Dependent Gene Expression Induced by PNIPAM-Based Copolymers:  Potential of Hyperthermia in Gene Transfer by Zintchenko, Arkadi, Ogris, Manfred, Wagner, Ernst

“…The objective of this work was to obtain gene delivery vectors with high efficiency induced by application of local hyperthermia. As a building construct for…”
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Functional modification of amide-crosslinked oligoethylenimine for improved siRNA delivery by Philipp, Alexander, Meyer, Martin, Zintchenko, Arkadi, Wagner, Ernst

“…The polymer OEI-HD-1, a degradable 25 kDa carrier for siRNA transfer based on β-propionamide-crosslinked oligoethylenimine, was functionalized to further…”
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Transition Highly Aggregated ComplexesSoluble Complexes via Polyelectrolyte Exchange Reactions:  Kinetics, Structural Changes, and Mechanism by Zintchenko, Arkadi, Rother, Gudrun, Dautzenberg, Herbert

“…The dissolution of highly aggregated polyelectrolyte complex particles formed in water after addition of salt was studied. The dissolution of aggregates…”
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Hyperthermia-induced targeting of thermosensitive gene carriers to tumors by Schwerdt, Alenka, Zintchenko, Arkadi, Concia, Massimo, Roesen, Nick, Fisher, Kerry, Lindner, Lars H, Issels, Rolf, Wagner, Ernst, Ogris, Manfred

“…Locoregional hyperthermia (HT) can be used for site-directed activation of macromolecular drug delivery systems. We have developed a gene delivery system based…”
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Improved Synthesis Strategy of Poly(amidoamine)s for Biomedical Applications: Catalysis by "Green" Biocompatible Earth Alkaline Metal Salts by Zintchenko, Arkadi, van der Aa, Leonardus J., Engbersen, Johan F. J.

“…Poly(amidoamine)s (PAAs) have received significant attention due to their good biocompatibility and fast biodegradation profile which gives these polymers high…”
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Simple Modifications of Branched PEI Lead to Highly Effident siRNA Carriers with Low Toxicity by Zintchenko, Arkadi, Philipp, Alexander, Dehshahri, Ali, Wagner, Ernst

“…Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current…”
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Polyelectrolyte Complex Formation with Double Hydrophilic Block Polyelectrolytes:  Effects of the Amount and Length of the Neutral Block by Zintchenko, Arkadi, Dautzenberg, Herbert, Tauer, Klaus, Khrenov, Viktor

“…Anionic and cationic block copolymers containing different fractions and chain lengths of poly(ethylene glycol) (PEG) blocks were synthesized and…”
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Ternary Conjugates as a Result of Exchange Reactions Between Polyelectrolyte Complexes and Surfactants: Formation and Stability by Zintchenko, Arkadi, Koňák, Čestmir

“…The exchange of sodium polymethacrylate (Na‐PMA) for anionic surfactant sodium dodecylsulfate (SDS) in a polyelectrolyte complex of Na‐PMA and poly(L‐lysine)…”
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Polycationic Graft Copolymers as Carriers for Oligonucleotide Delivery. Complexes of Oligonucleotides with Polycationic Graft Copolymers by Dautzenberg, Herbert, Zintchenko, Arkadi, Koňák, Čestmír, Reschel, Tomáš, Šubr, Vladimír, Ulbrich, Karel

“…Self-assembling systems based on ionic complexes of oligonucleotides (36 base pairs) and model oligophosphates (polymerization degree of 35) with high…”
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Interaction of DNA/Polycation Complexes with Phospholipids: Stabilizing Strategy for Gene Delivery by Zintchenko, Arkadi, Koňák, Čestmír

“…The interaction between negatively charged lipid vesicles and positively charged DNA/polylysine complexes was studied. The interaction does not lead to release…”
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Cationic Graft Copolymers as Carriers for Delivery of Antisense by Dautzenberg, Herbert, Konak, Cestmir, Reschel, Tomas, Zintchenko, Arkadi, Ulbrich, Karel

“…Self-assembling systems based on ionic complexes of DNA fragments (36 base pairs), bcl-2 antisense oligonucleotides (octadecamer), oligophosphates (25…”
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Cationic Graft Copolymers as Carriers for Delivery of Antisense-Oligonucleotides by Dautzenberg, Herbert, Koňák, Čestmír, Reschel, Tomáš, Zintchenko, Arkadi, Ulbrich, Karel

“…Self‐assembling systems based on ionic complexes of DNA fragments (36 base pairs), bcl‐2 antisense oligonucleotides (octadecamer), oligophosphates (25…”
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General approach for lipases immobilization in polyelectrolyte complexes by Zaitsev, Sergei Yu, Gorokhova, Irina V., Kashtigo, Tatjana V., Zintchenko, Arkadi, Dautzenberg, Herbert

“…Different lipase preparations were immobilized at various conditions in polyelectrolyte complexes (PEC) of Na-poly(styrene sulfonates) (as polyanions) and…”
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