Search Results - "Zinn‐Justin, Sophie"

Protein structural and mechanistic basis of progeroid laminopathies by Marcelot, Agathe, Worman, Howard J., Zinn‐Justin, Sophie

“…Progeroid laminopathies are characterized by the premature appearance of certain signs of physiological aging in a subset of tissues. They are caused by…”
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Sensitivity‐Enhanced 13C‐NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and pH by Alik, Ania, Bouguechtouli, Chafiaa, Julien, Manon, Bermel, Wolfgang, Ghouil, Rania, Zinn‐Justin, Sophie, Theillet, Francois‐Xavier

“…Abundant phosphorylation events control the activity of nuclear proteins involved in gene regulation and DNA repair. These occur mostly on disordered regions…”
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Protein−Protein Interfaces Probed by Methyl Labeling and Proton‐Detected Solid‐State NMR Spectroscopy by Zinke, Maximilian, Fricke, Pascal, Lange, Sascha, Zinn‐Justin, Sophie, Lange, Adam

“…Proton detection and fast magic‐angle spinning have advanced biological solid‐state NMR, allowing for the backbone assignment of complex protein assemblies…”
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Bacteriophage Tail‐Tube Assembly Studied by Proton‐Detected 4D Solid‐State NMR by Zinke, Maximilian, Fricke, Pascal, Samson, Camille, Hwang, Songhwan, Wall, Joseph S., Lange, Sascha, Zinn‐Justin, Sophie, Lange, Adam

“…Obtaining unambiguous resonance assignments remains a major bottleneck in solid‐state NMR studies of protein structure and dynamics. Particularly for…”
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Architecture of the flexible tail tube of bacteriophage SPP1 by Zinke, Maximilian, Sachowsky, Katrin A. A., Öster, Carl, Zinn-Justin, Sophie, Ravelli, Raimond, Schröder, Gunnar F., Habeck, Michael, Lange, Adam

“…Bacteriophage SPP1 is a double-stranded DNA virus of the Siphoviridae family that infects the bacterium Bacillus subtilis . This family of phages features a…”
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Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases by Samson, Camille, Petitalot, Ambre, Celli, Florian, Herrada, Isaline, Ropars, Virginie, Le Du, Marie-Hélène, Nhiri, Naïma, Jacquet, Eric, Arteni, Ana-Andrea, Buendia, Brigitte, Zinn-Justin, Sophie

“…Abstract Lamins are the main components of the nucleoskeleton. Whereas their 3D organization was recently described using cryoelectron tomography, no…”
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Sensitivity-Enhanced 13 C-NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and pH by Alik, Ania, Bouguechtouli, Chafiaa, Julien, Manon, Bermel, Wolfgang, Ghouil, Rania, Zinn-Justin, Sophie, Theillet, Francois-Xavier

“…Abundant phosphorylation events control the activity of nuclear proteins involved in gene regulation and DNA repair. These occur mostly on disordered regions…”
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Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1 by Ehlén, Åsa, Martin, Charlotte, Miron, Simona, Julien, Manon, Theillet, François-Xavier, Ropars, Virginie, Sessa, Gaetana, Beaurepere, Romane, Boucherit, Virginie, Duchambon, Patricia, El Marjou, Ahmed, Zinn-Justin, Sophie, Carreira, Aura

“…The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity through its role in homologous recombination. In mitosis, BRCA2 is…”
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Mechanism of MRX inhibition by Rif2 at telomeres by Roisné-Hamelin, Florian, Pobiega, Sabrina, Jézéquel, Kévin, Miron, Simona, Dépagne, Jordane, Veaute, Xavier, Busso, Didier, Du, Marie-Hélène Le, Callebaut, Isabelle, Charbonnier, Jean-Baptiste, Cuniasse, Philippe, Zinn-Justin, Sophie, Marcand, Stéphane

“…Specific proteins present at telomeres ensure chromosome end stability, in large part through unknown mechanisms. In this work, we address how the…”
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Solution structure of the region 51–160 of human KIN17 reveals an atypical winged helix domain by Carlier, Ludovic, Couprie, Joël, le Maire, Albane, Guilhaudis, Laure, Milazzo‐Segalas, Isabelle, Courçon, Marie, Moutiez, Mireille, Gondry, Muriel, Davoust, Daniel, Gilquin, Bernard, Zinn‐Justin, Sophie

“…Human KIN17 is a 45‐kDa eukaryotic DNA‐ and RNA‐binding protein that plays an important role in nuclear metabolism and in particular in the general response to…”
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Structural rearrangements in the phage head-to-tail interface during assembly and infection by Chaban, Yuriy, Lurz, Rudi, Brasilès, Sandrine, Cornilleau, Charlène, Karreman, Matthia, Zinn-Justin, Sophie, Tavares, Paulo, Orlova, Elena V.

“…Significance Stable genome maintenance inside viral particles and its controlled delivery to the host are critical for virus infection. We report cryoEM…”
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Dissecting the roles of Haspin and VRK1 in histone H3 phosphorylation during mitosis by Cartwright, Tyrell N., Harris, Rebecca J., Meyer, Stephanie K., Mon, Aye M., Watson, Nikolaus A., Tan, Cheryl, Marcelot, Agathe, Wang, Fangwei, Zinn-Justin, Sophie, Traktman, Paula, Higgins, Jonathan M. G.

“…Protein kinases that phosphorylate histones are ideally-placed to influence the behavior of chromosomes during cell division. Indeed, a number of conserved…”
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BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination by Ghouil, Rania, Miron, Simona, Koornneef, Lieke, Veerman, Jasper, Paul, Maarten W., Le Du, Marie-Hélène, Sleddens-Linkels, Esther, van Rossum-Fikkert, Sari E., van Loon, Yvette, Felipe-Medina, Natalia, Pendas, Alberto M., Maas, Alex, Essers, Jeroen, Legrand, Pierre, Baarends, Willy M., Kanaar, Roland, Zinn-Justin, Sophie, Zelensky, Alex N.

“…BRCA2 and its interactors are required for meiotic homologous recombination (HR) and fertility. Loss of HSF2BP, a BRCA2 interactor, disrupts HR during…”
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Emerin self‐assembly mechanism: role of the LEM domain by Samson, Camille, Celli, Florian, Hendriks, Kitty, Zinke, Maximilian, Essawy, Nada, Herrada, Isaline, Arteni, Ana‐Andreea, Theillet, François‐Xavier, Alpha‐Bazin, Béatrice, Armengaud, Jean, Coirault, Catherine, Lange, Adam, Zinn‐Justin, Sophie

“…At the nuclear envelope, the inner nuclear membrane protein emerin contributes to the interface between the nucleoskeleton and the chromatin. Emerin is an…”
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Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating by Lhuillier, Sophie, Gallopin, Matthieu, Gilquin, Bernard, Brasilès, Sandrine, Lancelot, Nathalie, Letellier, Guillaume, Gilles, Mathilde, Dethan, Guillaume, Orlova, Elena V, Couprie, Joël, Tavares, Paulo, Zinn-Justin, Sophie

“…In many bacterial viruses and in certain animal viruses, the double-stranded DNA genome enters and exits the capsid through a portal gatekeeper. We report a…”
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Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain by Maisonneuve, Pierre, Caillet‐Saguy, Célia, Raynal, Bertrand, Gilquin, Bernard, Chaffotte, Alain, Pérez, Javier, Zinn‐Justin, Sophie, Delepierre, Muriel, Buc, Henri, Cordier, Florence, Wolff, Nicolas

“…The human protein tyrosine phosphatase non‐receptor type 4 (PTPN4) prevents cells death. Targeting its PDZ domain abrogates this protection and triggers…”
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Intrinsic Disorder and Phosphorylation in BRCA2 Facilitate Tight Regulation of Multiple Conserved Binding Events by Julien, Manon, Ghouil, Rania, Petitalot, Ambre, Caputo, Sandrine M, Carreira, Aura, Zinn-Justin, Sophie

“…The maintenance of genome integrity in the cell is an essential process for the accurate transmission of the genetic material. BRCA2 participates in this…”
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The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH by Araye, Anne, Goudet, Amélie, Barbier, Julien, Pichard, Sylvain, Baron, Bruno, England, Patrick, Pérez, Javier, Zinn-Justin, Sophie, Chenal, Alexandre, Gillet, Daniel

“…Botulinum neurotoxin A (BoNT/A) is composed of three domains: a catalytic domain (LC), a translocation domain (HN) and a receptor-binding domain (HC). Like…”
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Solution structure of gp17 from the Siphoviridae bacteriophage SPP1: Insights into its role in virion assembly by Chagot, Benjamin, Auzat, Isabelle, Gallopin, Matthieu, Petitpas, Isabelle, Gilquin, Bernard, Tavares, Paulo, Zinn-Justin, Sophie

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A De Novo Sequence Variant in Barrier-to-Autointegration Factor Is Associated with Dominant Motor Neuronopathy by Marcelot, Agathe, Rodriguez-Tirado, Felipe, Cuniasse, Philippe, Joiner, Mei-Ling, Miron, Simona, Soshnev, Alexey A, Fang, Mimi, Pufall, Miles A, Mathews, Katherine D, Moore, Steven A, Zinn-Justin, Sophie, Geyer, Pamela K

“…Barrier-to-autointegration factor (BAF) is an essential component of the nuclear lamina. Encoded by , this DNA binding protein contributes to the regulation of…”
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