Search Results - "Zinke, P W"

Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist by Hellberg, M R, Sallee, V L, McLaughlin, M A, Sharif, N A, Desantis, L, Dean, T R, Zinke, P W

“…Travoprost is the isopropyl ester prodrug of a high affinity, selective FP prostaglandin full receptor agonist. In contrast to travoprost acid's high affinity…”
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Structure of a key intermediate in the asymmetric synthesis of (+)-KDO by Lynch, V M, Zinke, P W, Martin, S F, Davis, B E

“…Methyl 3-deoxy-7,8-O-(1-methylethylidene)- 1-O-(phenylmethyl)-alpha-D-manno-2-octalopyranoside cyclic carbonate, (1), C20H26O8, Mr = 394.42, orthorhombic,…”
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The furan approach to oxygenated natural products. Total synthesis of (+)-KDO by Martin, Stephen F, Zinke, Paul W

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Enantioselective Synthesis of AL-4414A, a Topically Active Carbonic Anhydrase Inhibitor by DuPriest, Mark T, Zinke, Paul W, Conrow, Raymond E, Kuzmich, Daniel, Dantanarayana, Anura P, Sproull, Steven J

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The furan approach to higher monosaccharides. A concise total synthesis of (+)-KDO by Martin, Stephen F, Zinke, Paul W

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Zinc-promoted reductive coupling reactions. Reaction of sodium methoxyalkenyldialkylborates(1-) with alkenylzinc chlorides or zinc chloride by Molander, Gary A, Zinke, Paul W

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1-((S)-2-Aminopropyl)-1H-indazol-6-ol:  A Potent Peripherally Acting 5-HT2 Receptor Agonist with Ocular Hypotensive Activity by May, Jesse A, Dantanarayana, Anura P, Zinke, Paul W, McLaughlin, Marsha A, Sharif, Najam A

“…Serotonin 5-HT2 receptor agonists have been identified as a potential new class of agents for the treatment of ocular hypertension and glaucoma. The initially…”
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Stereocontrolled cyclization reactions mediated by samarium diiodide by Molander, Gary A, Etter, Jeffrey B, Zinke, Paul W

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Identification and Characterization of the Ocular Hypotensive Efficacy of Travoprost, a Potent and Selective FP Prostaglandin Receptor Agonist, and AL-6598, a DP Prostaglandin Receptor Agonist by Hellberg, Mark R., McLaughlin, Marsha A., Sharif, Naj A., DeSantis, Louis, Dean, Tom R., Kyba, Evan P., Bishop, John E., Klimko, Peter G., Zinke, Paul W., Selliah, Robert D., Barnes, George, DeFaller, Joseph, Kothe, Angela, Landry, Theresa, Sullivan, E.Kenneth, Andrew, Russell, Davis, Alberta A., Silver, Lewis, Bergamini, Michael V.W., Robertson, Stella, Weiner, Alan L., Sallee, Verney L.

“…The structure-activity studies that led to the identification of travoprost, a highly selective and potent FP prostaglandin analog, and AL-6598, a DP…”
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3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents by Hellberg, Mark R., Conrow, Raymond E., Sharif, Najam A., McLaughlin, Marsha A., Bishop, John E., Crider, Julie Y., Dean, W.Dennis, DeWolf, Kevin A., Pierce, David R., Sallee, Verney L., Selliah, Robert D., Severns, Bryon S., Sproull, Steven J., Williams, Gary W., Zinke, Paul W., Klimko, Peter G.

“…A series of prostaglandin DP agonists containing a 3-oxa-15-cyclohexyl motif was synthesized and evaluated in several in vitro and in vivo biological assays…”
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Enantioselective Synthesis of Brinzolamide (AL-4862), a New Topical Carbonic Anhydrase Inhibitor. The “DCAT Route” to Thiophenesulfonamides by Conrow, Raymond E, Dean, W. Dennis, Zinke, Paul W, Deason, Michael E, Sproull, Steven J, Dantanarayana, Anura P, DuPriest, Mark T

“…A large scale synthesis of the topical carbonic anhydrase inhibitors AL-4623A (13a·HCl) and AL-4862 (13b) from 3-acetyl-2,5-dichlorothiophene (“DCAT”, 1) is…”
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