Search Results - "Zink, W."

Local anesthetic myotoxicity by Zink, Wolfgang, Graf, Bernhard M

“…Skeletal muscle toxicity is a rare and uncommon side effect of local anesthetic drugs. Intramuscular injections of these agents regularly result in reversible…”
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Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model by Aumeier, C., Kasdorf, B., Gruber, M., Busse, H., Wiese, C.H., Zink, W., Graf, B.M., Zausig, Y.A.

“…The use of lipid emulsions to reduce cardiac toxicity of local anaesthetics (LAs) has shown success in experimental studies and some clinical cases, and thus…”
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The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand by Burris, Thomas P, Montrose, Chahrzad, Houck, Keith A, Osborne, Harold E, Bocchinfuso, Wayne P, Yaden, Benjamin C, Cheng, Christine C, Zink, Richard W, Barr, Robert J, Hepler, Christoper D, Krishnan, Venkatesh, Bullock, Heather A, Burris, Lorri L, Galvin, Rachelle J, Bramlett, Kelli, Stayrook, Keith R

“…Guggulsterone (GS) is the active substance in guggulipid, an extract of the guggul tree, Commiphora mukul, used to treat a variety of disorders in humans,…”
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Inefficacy of simulator-based training on anaesthesiologists' non-technical skills by ZAUSIG, Y. A., GRUBE, C., BOEKER-BLUM, T., BUSCH, C. J., BAYER, Y., SINNER, B., ZINK, W., SCHAPER, N., GRAF, B. M.

“…Background: Analysis of critical incidents in anaesthesia practice emphasizes the important role of non‐technical skills (NTS) in improving patient safety…”
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The Acute Myotoxic Effects of Bupivacaine and Ropivacaine After Continuous Peripheral Nerve Blockades by Zink, Wolfgang, Seif, Christoph, Bohl, Jürgen R. E., Hacke, Nicola, Braun, Peter M., Sinner, Barbara, Martin, Eike, Fink, Rainer H. A., Graf, Bernhard M.

“…Bupivacaine causes muscle damage. However, the myotoxic potency of ropivacaine is still unexplored. Therefore, we performed this study to compare the effects…”
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Secondary Clinical Deterioration after Successful Embolization of a Spinal Dural Arteriovenous Fistula: A Plea for Prophylactic Anticoagulation by Knopman, J., Zink, W., Patsalides, A., Riina, H.A., Gobin, Y.P.

“…We present a case of delayed aggravation of initially-resolved symptoms in a patient after successful embolization of a T5 spinal dural arteriovenous (AV)…”
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Hippocampal synaptic dysfunction in a murine model of human immunodeficiency virus type 1 encephalitis by ANDERSON, E. R, BOYLE, J, ZINK, W. E, PERSIDSKY, Y, GENDELMAN, H. E, XIONG, H

“…Alterations in hippocampal physiology affect cognition in human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD). The mechanism for how this…”
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Airway management in preclinical emergency anesthesia with respect to specialty and education by Luckscheiter, A, Lohs, T, Fischer, M, Zink, W

“…Difficult airway management is a key skill in preclinical emergency medicine. A lower rate of subjective difficult airways and an increased success rate of…”
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Effect of temperature of ropivacaine on onset time and anaesthetic quality in an ultrasound guided axillary plexus blockade. Comparison of ropivacaine 0.75% in three different temperatures (7°C, 21°C, 37°C): 8AP1–2 by Ehrenberg, R, Moritz, S, Graf, B, Zink, W

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Novel Microcatheters for Selective Intra-Arterial Injection of Fluid in the Rat Brain by Zink, W.E, Foley, C.P, Dyke, J.P, Synan, M.J, Chakrapani, A.L, Ballon, D.J, Olbricht, W.L, Gobin, Y.P

“…The internal carotid artery (ICA) in the rat has a single extracranial branch, which supplies the muscles of mastication. The rat ICA also has multiple…”
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Stocktaking of local anesthetics 2020 by Zink, W, Steinfeldt, T, Wiesmann, T

“…For decades local anesthetics have proven to be safe and effective drugs in the clinical practice, crucially promoting the enormous achievements in regional…”
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Simulation as an additional tool for investigating the performance of standard operating procedures in anaesthesia by Zausig, Y.A., Bayer, Y., Hacke, N., Sinner, B., Zink, W., Grube, C., Graf, B.M.

“…In medicine, the use of standard operating procedures (SOPs) is often evaluated using questionnaires (QUES). However, QUES can have limitations with regard to…”
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Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design by Hughes, Norman E., Bleisch, Thomas J., Jones, Scott A., Richardson, Timothy I., Doti, Robert A., Wang, Yong, Stout, Stephanie L., Durst, Gregory L., Chambers, Mark G., Oskins, Jennifer L., Lin, Chaohua, Adams, Lisa A., Page, Todd J., Barr, Robert J., Zink, Richard W., Osborne, Harold, Montrose-Rafizadeh, Chahrzad, Norman, Bryan H.

“…[Display omitted] A series of triaryl pyrazoles were identified as potent pan antagonists for the retinoic acid receptors (RARs) α, β and γ. X-ray…”
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Early Endovascular Management of Oculomotor Nerve Palsy Associated with Posterior Communicating Artery Aneurysms by Santillan, A., Zink, W.E., Knopman, J., Riina, H.A., Gobin, Y.P.

“…Palsy of the third cranial nerve (oculomotor nerve, CNIII) is a well-known clinical presentation of posterior communicating artery (P-com) aneurysm. We report…”
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Fatal course of COVID-19 despite IL-6 receptor blockade in cytokine storm : Perimyocarditis and coagulopathy after administration of tocilizumab by Bovet, M, Wadsack, D, Kosely, F, Zink, W, Zahn, R

“…A 59-year-old male patient was admitted to hospital diagnosed with moderate pneumonia associated with COVID-19. Upfront treatment with hydroxychloroquine and…”
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Preclinical emergency anesthesia : A current state analysis from 2015-2017 by Luckscheiter, A, Lohs, T, Fischer, M, Zink, W

“…Due to multiple factors the performance of preclinical emergency anesthesia is fraught with risks even for experienced emergency physicians. In order to…”
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Accelerating the convergence of the back-propagation method by VOGL, T. P, MANGIS, J. K, RIGLER, A. K, ZINK, W. T, ALKON, D. L

“…The utility of the back-propagation method in establishing suitable weights in a distributed adaptive network has been demonstrated repeatedly. Unfortunately,…”
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Spinal Cord Ischemia after Endovascular Repair of the Descending Thoracic Aorta in a Sheep Model by Böckler, D, Kotelis, D, Kohlhof, P, von Tengg-Kobligk, H, Mansmann, U, Zink, W, Hörner, C, Ortlepp, I, Habel, A, Kauczor, H.-U, Graf, B, Allenberg, J.-R

“…Objectives Spinal cord ischemia remains a devastating complication after thoracic aortic surgery. The aim of this study was to investigate the pathophysiology…”
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Continuous Assessment of Right Ventricular Ejection Fraction: New pulmonary artery catheter versus transoesophageal echocardiography by Zink, W., Nöll, J., Rauch, H., Bauer, H., DeSimone, R., Martin, E., Böttiger, B. W.

“…Summary In 25 cardiac surgical patients, right ventricular ejection fraction was continuously measured with a new pulmonary artery catheter and…”
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Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide‑1 Receptor by Willard, Francis S, Wainscott, David B, Showalter, Aaron D, Stutsman, Cynthia, Ma, Wenzhen, Cardona, Guemalli R, Zink, Richard W, Corkins, Christopher M, Chen, Qi, Yumibe, Nathan, Agejas, Javier, Cumming, Graham R, Minguez, José Miguel, Jiménez, Alma, Mateo, Ana I, Castaño, Ana M, Briere, Daniel A, Sloop, Kyle W, Bueno, Ana B

“…The identification of LSN3318839, a positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R), is described. LSN3318839 increases the…”
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