Search Results - "Zindl, Carlene L"
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Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis
Published in Proceedings of the National Academy of Sciences - PNAS (02-06-2015)“…Th17 cells reactive to the enteric microbiota are central to the pathogenesis of certain types of inflammatory bowel disease. However, Th17 cells display…”
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IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
Published in Proceedings of the National Academy of Sciences - PNAS (30-07-2013)“…IL-22 plays an important role in mucosal epithelial cell homeostasis. Using a dextran sodium sulfate-induced mouse model of acute colitis, we observed an…”
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Tumor Immune Evasion
Published in Science (American Association for the Advancement of Science) (07-05-2010)“…Malignant cells can induce the formation of lymphoid tissue–like structures that help the tumor evade host immunity. Many types of human tumors can suppress…”
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Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae
Published in PloS one (23-12-2010)“…Mycoplasma pneumoniae (Mp), a common cause of pneumonia, is associated with asthma; however, the mechanisms underlying this association remain unclear. We…”
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Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells
Published in Science (American Association for the Advancement of Science) (14-09-2018)“…In response to infection, naïve CD4 T cells differentiate into two subpopulations: T follicular helper (T ) cells, which support B cell antibody production,…”
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Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis
Published in Nature medicine (01-11-2019)“…Late-onset sepsis (LOS) is thought to result from systemic spread of commensal microbes from the intestines of premature infants. Clinical use of probiotics…”
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Distal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence
Published in Nature (London) (16-05-2024)“…Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier 1 – 3 . T cells, but not innate lymphoid cells, have an…”
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Regulatory T cells expressing interleukin 10 develop from Foxp3 + and Foxp3 − precursor cells in the absence of interleukin 10
Published in Nature immunology (01-09-2007)“…CD4(+) regulatory T cells (T(reg) cells) that produce interleukin 10 (IL-10) are important contributors to immune homeostasis. We generated mice with a…”
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IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription
Published in The Journal of biological chemistry (12-10-2018)“…Interleukin (IL)-1β plays a critical role in IL-6β– and transforming growth factor β (TGFβ)–initiated Th17 differentiation and induction of Th17-mediated…”
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A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts
Published in Immunity (Cambridge, Mass.) (08-03-2022)“…Interleukin (IL)-22 is central to immune defense at barrier sites. We examined the contributions of innate lymphoid cell (ILC) and T cell-derived IL-22 during…”
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Taking Control of Follicular Dendritic Cells
Published in Immunity (Cambridge, Mass.) (2006)“…Follicular dendritic cells signal the formation of B cell follicles as well as B cell activation, proliferation, and maturation. However, the precise molecular…”
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IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell–iTreg cell balance
Published in Nature immunology (01-03-2015)“…iT reg cells and T H 17 cells share developmental steps, but their cellular fate depends on environmental cues. Weaver and colleagues show that IL-1 signaling…”
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The Lymphotoxin LTα1β2 Controls Postnatal and Adult Spleen Marginal Sinus Vascular Structure and Function
Published in Immunity (Cambridge, Mass.) (20-03-2009)“…The lymphotoxin LTα 1 β 2 supports the development and maintenance of several aspects of spleen structure, but its significance for marginal sinus (MS)…”
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T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity
Published in Science immunology (17-07-2020)“…Acting in concert with TGF-β, interleukin-6 (IL-6) signaling induces T helper 17 (T 17) cell development by programming T 17-related genes via signal…”
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MMP induced by Gr-1⁺ cells are crucial for recruitment of Th cells into the airways
Published in European journal of immunology (01-08-2009)“…Th2 lymphocytes deliver essential signals for induction of asthmatic airway inflammation. We previously found that airway antigen challenge induces recruitment…”
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Induction of a late asthmatic response associated with airway inflammation in mice
Published in European journal of pharmacology (03-10-2005)“…To investigate mechanisms underlying the late asthmatic response, we developed a murine model using repetitive intratracheal antigen challenge. BALB/c mice…”
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Citrobacter rodentium: a model enteropathogen for understanding the interplay of innate and adaptive components of type 3 immunity
Published in Mucosal immunology (01-09-2017)“…Citrobacter rodentium is a natural murine intestinal pathogen that shares a core set of virulence factors with the related human pathogens enteropathogenic…”
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Temporal changes in cellular sources of CXC chemokines control neutrophil recruitment during Citrobacter rodentium infection
Published in The Journal of immunology (1950) (01-05-2020)“…Enteropathogenic E. coli (EPEC) is one of the leading causes of diarrheal disease among children. Citrobacter rodentium (C.r) is a mouse model for EPEC and…”
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A Non-redundant Role for T cell-derived Interleukin 22 in Antibacterial Defense of Colonic Crypts
Published in Immunity (Cambridge, Mass.) (08-03-2022)“…Interleukin (IL)-22 is central to immune defense at barrier sites. We examined the contributions of innate lymphoid cell (ILC) and T cell-derived IL-22 during…”
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Differential IL-2 Expression Defines Developmental Fates of Follicular versus Non-follicular Helper T cells
Published in Science (American Association for the Advancement of Science) (14-09-2018)“…In response to infection, naïve CD4 + T cells differentiate into two types of helpers: T follicular helper (Tfh) cells, which support B-cell antibody…”
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