Antioxidant and anti-inflammatory effects of quercetin in functional and morphological alterations in streptozotocin-induced diabetic rats

Antioxidant and anti-inflammatory effects of quercetin in functional and morphological alterations in streptozotocin-induced diabetic rats

The aim of this study was to investigate functional and morphological alterations caused by oxidative stress in streptozotocin (STZ)-induced diabetic rats and to evaluate the antioxidant effect of quercetin (QUE) in this disease. One hundred and thirty male Wistar rats, it were randomly distributed...

Full description

Saved in:
Bibliographic Details
Published in:Research in veterinary science Vol. 95; no. 2; pp. 389 - 397
Main Authors: Maciel, R.M., Costa, M.M., Martins, D.B., França, R.T., Schmatz, R., Graça, D.L., Duarte, M.M.M.F., Danesi, C.C., Mazzanti, C.M., Schetinger, M.R.C., Paim, F.C., Palma, H.E., Abdala, F.H., Stefanello, N., Zimpel, C.K., Felin, D.V., Lopes, S.T.A.
Format: Journal Article
Language:English
Published: England Elsevier India Pvt Ltd 01-10-2013
Elsevier Limited
Subjects:
Animals
anti-inflammatory activity
anti-inflammatory agents
Anti-Inflammatory Agents - pharmacology
Anticoagulants
antioxidant activity
Antioxidants
Antioxidants - pharmacology
Catalase - genetics
Catalase - metabolism
Cats
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - pathology
Dogs
Ethanol
Experiments
free radicals
Gene Expression Regulation, Enzymologic - physiology
Hematology
Hepatic enzymes
hyperglycemia
Insulin
Insulin resistance
Lipid Peroxidation - drug effects
Male
Oxidative stress
Proteins
Proteins electrophoresis
quercetin
Quercetin - pharmacology
Rats
Rats, Wistar
Rodents
streptozotocin
Studies
Superoxide Dismutase - genetics
Superoxide Dismutase - metabolism
Veterinary medicine
Proteins electrophoresis
Oxidative stress
Hepatic enzymes
Diabetes mellitus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to investigate functional and morphological alterations caused by oxidative stress in streptozotocin (STZ)-induced diabetic rats and to evaluate the antioxidant effect of quercetin (QUE) in this disease. One hundred and thirty male Wistar rats, it were randomly distributed in 10 different experimental groups, with ten animals per group: Control Saline (CS), Control Ethanol (CE), Control QUE 5mg/kg (CQ5), Control QUE 25mg/kg (CQ25), Control QUE 50mg/kg (CQ50), Diabetic Saline (DS), Diabetic Ethanol (DE), Diabetic QUE 5mg/kg (DQ5), Diabetic QUE25mg/kg (DQ25), Diabetic QUE 50mg/kg (DQ50). Therefore, hyperglycemia is directly involved in oxidative stress production, as well as in functional and morphological alterations caused by the excess of free radicals. QUE, specially at the dosage of 50mg/kg, can act as an antioxidant and anti-inflammatory agent, becoming a promising adjuvant in the treatment of diabetes mellitus.
Bibliography:http://dx.doi.org/10.1016/j.rvsc.2013.04.028
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2013.04.028